Validation of Intervention Effect of Feeling Sense of Qi in Spirituality and Leadership relation in practices of Sundo Meditatio

2017 ◽  
Vol 23 ◽  
pp. 41-70
Author(s):  
Ho-Chan Seo ◽  
Hye-Sook Shin
Keyword(s):  
Intervention Effect

Does CBT for Psychosis Have an Impact on Delusions by Improving Reasoning Biases and Negative Self-Schemas?

2018 ◽  
Vol 226 (3) ◽  
pp. 152-163 ◽  
Author(s):  
Stephanie Mehl ◽  
Björn Schlier ◽  
Tania M. Lincoln
Keyword(s):  
Behavioral Therapy ◽  
Theoretical Models ◽  
Self Esteem ◽  
Secondary Outcome ◽  
Intervention Effect ◽  
Produce Change ◽  
Attribution Biases ◽  
Carry Over ◽  
Implicit And Explicit ◽  
Reasoning Biases

Abstract. Cognitive-behavioral therapy for psychosis (CBTp) builds on theoretical models that postulate reasoning biases and negative self-schemas to be involved in the formation and maintenance of delusions. However, it is unclear whether CBTp induces change in delusions by improving these proposed causal mechanisms. This study reports on a mediation analysis of a CBTp effectiveness trial in which delusions were a secondary outcome. Patients with psychosis were randomized to individualized CBTp (n = 36) or a waiting list condition (WL; n = 34). Reasoning biases (jumping to conclusions, theory of mind, attribution biases) and self-schemas (implicit and explicit self-esteem; self-schemas related to different domains) were assessed pre- and post-therapy/WL. The results reveal an intervention effect on two of four measures of delusions and on implicit self-esteem. Nevertheless, the intervention effect on delusions was not mediated by implicit self-esteem. Changes in explicit self-schemas and reasoning biases did also not mediate the intervention effects on delusions. More focused interventions may be required to produce change in reasoning and self-schemas that have the potential to carry over to delusions.

Impact of titanium dioxide nanoparticles on intestinal community in the 2,4,6-Trinitrobenzenesulfonic acid (TNBS)-induced acute colitis mice and the intervention effect of vitamin E

Nanoscale ◽  
2020 ◽  
Author(s):  
Yanjun Gao ◽  
Tingyu Li ◽  
Shuming Duan ◽  
Lizhi Lv ◽  
Yuan Li ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Titanium Dioxide ◽  
Vitamin E ◽  
Titanium Dioxide Nanoparticles ◽  
Trinitrobenzenesulfonic Acid ◽  
Acute Colitis ◽  
Intervention Effect ◽  
Tio2 Nps

Titanium dioxide nanoparticles (TiO2-NPs) is widely applicated as additives in foods for its excellent whitening and brightening capability. Although the toxicity and antibacterial activity of TiO2-NPs has been extensively studied,...

scholarly journals Japan’s voluntary lockdown: further evidence based on age-specific mobile location data

2021 ◽  
Author(s):  
Tsutomu Watanabe ◽  
Tomoyoshi Yabu
Keyword(s):  
Age Groups ◽  
Evidence Based ◽  
Intervention Effect ◽  
Information Effect ◽  
Mobile Location ◽  
Serious Illness ◽  
Location Data ◽  
Voluntary Response ◽  
Younger Age ◽  
Age Profile

AbstractChanges in people’s behavior during the COVID-19 pandemic can be regarded as the result of two types of effects: the “intervention effect” (changes resulting from government orders for people to change their behavior) and the “information effect” (voluntary changes in people’s behavior based on information about the pandemic). Using age-specific mobile location data, we examine how the intervention and information effects differ across age groups. Our main findings are as follows. First, the age profile of the intervention effect shows that the degree to which people refrained from going out was smaller for older age groups, who are at a higher risk of serious illness and death, than for younger age groups. Second, the age profile of the information effect shows that the degree to which people stayed at home tended to increase with age for weekends and holidays. Thus, while Acemoglu et al. (2020) proposed targeted lockdowns requiring stricter lockdown policies for the oldest group in order to protect those at a high risk of serious illness and death, our findings suggest that Japan’s government intervention had a very different effect in that it primarily reduced outings by the young, and what led to the quarantining of older groups at higher risk instead was people’s voluntary response to information about the pandemic. Third, the information effect has been on a downward trend since the summer of 2020. It is relatively more pronounced among the young, so that the age profile of the information effect remains upward sloping.

scholarly journals Can Working Conditions and Employees’ Mental Health Be Improved via Job Stress Interventions Designed and Implemented by Line Managers and Human Resources on an Operational Level?

2021 ◽  
Vol 18 (4) ◽  
pp. 1916 ◽  
Author(s):  
Magnus Akerstrom ◽  
Linda Corin ◽  
Jonathan Severin ◽  
Ingibjörg H. Jonsdottir ◽  
Lisa Björk
Keyword(s):  
Human Resources ◽  
Sickness Absence ◽  
Working Conditions ◽  
Employee Turnover ◽  
Reference Groups ◽  
Intervention Effect ◽  
Intervention Effects ◽  
Line Managers ◽  
Operational Level ◽  
Organisational Level

Organisational-level interventions are recommended for decreasing sickness absence, but knowledge of the optimal design and implementation of such interventions is scarce. We collected data on working conditions, motivation, health, employee turnover, and sickness absence among participants in a large-scale organisational-level intervention comprising measures designed and implemented by line managers and their human resources partners (i.e., operational-level). Information regarding the process, including the implementation of measures, was retrieved from a separate process evaluation, and the intervention effects were investigated using mixed-effects models. Data from reference groups were used to separate the intervention effect from the effects of other concurrent changes at the workplace. Overall, working conditions and motivation improved during the study for both the intervention and reference groups, but an intervention effect was only seen for two of 13 evaluated survey items: clearness of objectives (p = 0.02) and motivation (p = 0.06). No changes were seen in employees’ perceived health, and there were no overall intervention effects on employee turnover or sickness absence. When using operational-level workplace interventions to improve working conditions and employees’ health, efforts must be made to achieve a high measure-to-challenge correspondence; that is, the implemented measures must be a good match to the problems that they are intended to address.

scholarly journals Secular trends of population attributable risk of overweight and obesity for hypertension among Chinese adults from 1991 to 2011

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jian Gou ◽  
Huiying Wu
Keyword(s):  
Population Attributable Risk ◽  
Attributable Risk ◽  
Secular Trends ◽  
Overweight And Obesity ◽  
Regression Coefficients ◽  
Chinese Adults ◽  
Intervention Effect ◽  
Obesity Epidemic ◽  
The Past ◽  
Increasing Trend

AbstractWe determined if the increasing trend in hypertension can be partly attributed to increasing prevalence of overweight/obesity in China over the past two decades. Data were collected from 1991 to 2011 and the population attributable risk (PAR), which is used to estimate the intervention effect on hypertension if overweight/obese, were eliminated. Linear regression was used to evaluate the secular trends. The age-standardized prevalence of overweight and obesity increased by 26.32% with an overall slope of 1.27% (95% CI: 1.12–1.43%) per year. Hypertension also increased by 12.37% with an overall slope of 0.65% (95% CI: 0.51–0.79%) per year. The adjusted ORs of overweight/obesity for hypertension across the survey years remained unchanged; however, the trend in PAR increased steadily from 27.1 to 44.6% with an overall slope of 0.81% (95% CI: 0.34–1.28%) per year (P = 0.006). There was no significant gender difference in the slopes of increasing PAR, as measured by regression coefficients (β = 0.95% vs. β = 0.63% per year, P = 0.36). Over the past two decades, the increase in the prevalence of hypertension in China was partly attributed to the overweight/obesity epidemic, which highlights the importance of controlling weight and further reducing the burden of hypertension.

scholarly journals Accounting for confounding by time, early intervention adoption, and time-varying effect modification in the design and analysis of stepped-wedge designs: application to a proposed study design to reduce opioid-related mortality

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Lior Rennert ◽  
Moonseong Heo ◽  
Alain H. Litwin ◽  
Victor De Gruttola
Keyword(s):  
Mixed Effects ◽  
Effect Modification ◽  
External Factors ◽  
Mixed Effects Models ◽  
Time Varying ◽  
Intervention Effect ◽  
Type 1 Error ◽  
And Control ◽  
Related Mortality

Abstract Background Beginning in 2019, stepped-wedge designs (SWDs) were being used in the investigation of interventions to reduce opioid-related deaths in communities across the United States. However, these interventions are competing with external factors such as newly initiated public policies limiting opioid prescriptions, media awareness campaigns, and the COVID-19 pandemic. Furthermore, control communities may prematurely adopt components of the intervention as they become available. The presence of time-varying external factors that impact study outcomes is a well-known limitation of SWDs; common approaches to adjusting for them make use of a mixed effects modeling framework. However, these models have several shortcomings when external factors differentially impact intervention and control clusters. Methods We discuss limitations of commonly used mixed effects models in the context of proposed SWDs to investigate interventions intended to reduce opioid-related mortality, and propose extensions of these models to address these limitations. We conduct an extensive simulation study of anticipated data from SWD trials targeting the current opioid epidemic in order to examine the performance of these models in the presence of external factors. We consider confounding by time, premature adoption of intervention components, and time-varying effect modification— in which external factors differentially impact intervention and control clusters. Results In the presence of confounding by time, commonly used mixed effects models yield unbiased intervention effect estimates, but can have inflated Type 1 error and result in under coverage of confidence intervals. These models yield biased intervention effect estimates when premature intervention adoption or effect modification are present. In such scenarios, models incorporating fixed intervention-by-time interactions with an unstructured covariance for intervention-by-cluster-by-time random effects result in unbiased intervention effect estimates, reach nominal confidence interval coverage, and preserve Type 1 error. Conclusions Mixed effects models can adjust for different combinations of external factors through correct specification of fixed and random time effects. Since model choice has considerable impact on validity of results and study power, careful consideration must be given to how these external factors impact study endpoints and what estimands are most appropriate in the presence of such factors.

scholarly journals Results of the CHlorhexidine Gluconate Bathing implementation intervention to improve evidence-based nursing practices for prevention of central line associated bloodstream infections Study (CHanGing BathS): a stepped wedge cluster randomized trial

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Staci S. Reynolds ◽  
Patricia Woltz ◽  
Edward Keating ◽  
Janice Neff ◽  
Jennifer Elliott ◽  
...  
Keyword(s):  
Implementation Strategies ◽  
Bloodstream Infections ◽  
Central Line ◽  
Audit And Feedback ◽  
Educational Outreach ◽  
Evidence Based ◽  
Intervention Effect ◽  
Cluster Randomized ◽  
Outreach Visits ◽  
Educational Outreach Visits

Abstract Background Central line-associated bloodstream infections (CLABSIs) result in approximately 28,000 deaths and approximately $2.3 billion in added costs to the U.S. healthcare system each year, and yet, many of these infections are preventable. At two large health systems in the southeast United States, CLABSIs continue to be an area of opportunity. Despite strong evidence for interventions to prevent CLABSI and reduce associated patient harm, such as use of chlorhexidine gluconate (CHG) bathing, the adoption of these interventions in practice is poor. The primary objective of this study was to assess the effect of a tailored, multifaceted implementation program on nursing staff’s compliance with the CHG bathing process and electronic health record (EHR) documentation in critically ill patients. The secondary objectives were to examine the (1) moderating effect of unit characteristics and cultural context, (2) intervention effect on nursing staff’s knowledge and perceptions of CHG bathing, and (3) intervention effect on CLABSI rates. Methods A stepped wedged cluster-randomized design was used with units clustered into 4 sequences; each sequence consecutively began the intervention over the course of 4 months. The Grol and Wensing Model of Implementation helped guide selection of the implementation strategies, which included educational outreach visits and audit and feedback. Compliance with the appropriate CHG bathing process and daily CHG bathing documentation were assessed. Outcomes were assessed 12 months after the intervention to assess for sustainability. Results Among the 14 clinical units participating, 8 were in a university hospital setting and 6 were in community hospital settings. CHG bathing process compliance and nursing staff’s knowledge and perceptions of CHG bathing significantly improved after the intervention (p = .009, p = .002, and p = .01, respectively). CHG bathing documentation compliance and CLABSI rates did not significantly improve; however, there was a clinically significant 27.4% decrease in CLABSI rates. Conclusions Using educational outreach visits and audit and feedback implementation strategies can improve adoption of evidence-based CHG bathing practices. Trial registration ClinicalTrials.gov, NCT03898115, Registered 28 March 2019.

scholarly journals Changes in behavioral outcomes among children affected by HIV: Results of a randomized controlled trial in China

2017 ◽  
Vol 24 (11) ◽  
pp. 1581-1594 ◽  
Author(s):  
Li Li ◽  
Li-Jung Liang ◽  
Chunqing Lin ◽  
Chiao-Wen Lan ◽  
Guoping Ji ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Behavioral Outcomes ◽  
Negative Behavior ◽  
Intervention Effect ◽  
Negative Behaviors ◽  
Intervention Approach ◽  
Randomized Controlled ◽  
Multilevel Intervention

This study assessed the effects of a multilevel intervention on HIV-affected children’s negative behaviors. A total of 536 children aged 6–18 years from 475 HIV-affected families in Anhui, China, participated in the randomized controlled trial. A significant overall intervention effect on reducing negative behaviors was observed at 18-month follow-up, and the effect remained at 24-month follow-up. The intervention showed greater effects for children aged 13–18 years than those aged 6–12 years. Study findings suggest that a multilevel intervention approach could be beneficial for reducing negative behavior in HIV-affected children. Age-specific programs should be considered to maximize the intervention effects.

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