scholarly journals Comparison of infusion of Propofol and Isoflurane on blood glucose level during surgery in type 2 diabetic patient

Author(s):  
Mohammad Farzad Malekzadeh ◽  
Mohammad Golparvar

Background: Type 2 diabetes mellitus is a chronic metabolic disease, known as the most common type of diabetes and is associated with hyperglycemia, insulin resistance, and insulin-dependent infertility. Isoflurane and Propofol are two commonly used drugs in anesthetics that have different effects on various systems in the body; however, limited studies have been done on the impact of these two medications on the blood glucose level in diabetic patients. The purpose of this study is to compare the effects of Propofol and Isoflurane on the blood glucose levels in patients with type 2 diabetes mellitus who are surgical candidates. Methods: This clinical trial study was conducted on a group of patients with type 2 diabetes mellitus who were candidates for elective surgery. Participants were selected based on the order of referral using convenience sampling method and entered the study after evaluating inclusion and exclusion criteria. First, patients' demographic data were recorded and then they were randomly divided into two groups to receive Isoflurane and Propofol. The vital signs of the patients were recorded before and during anesthesia every 15 minutes. Blood glucose levels were measured by the glucose meter before surgery and one hour after the start of the anesthetic maintenance. Results: There was no significant difference between the mean blood glucose level before surgery and at the end of recovery in any of the study groups. Moreover, the mean of blood glucose level before the surgery and at the end of recovery and the difference in the mean of blood glucose level in both groups of Isoflurane and Propofol in different time intervals were not significantly different (P< 0.05). Comparison of blood glucose level before and after surgery in each group showed that there was no significant difference in the level of glucose before and after the surgical operation in the Isoflurane group (P= 0.3), but in the Propofol group, the level of blood glucose had decreased significantly after the surgical operation (P= 0.014). Conclusion: Maintenance of anesthesia with Propofol in comparison with the inhaled Isoflurane during the surgical operation can lead to a reduction in the blood glucose levels after the surgery compared to the preoperative state.

2016 ◽  
Vol 113 (29) ◽  
pp. 8168-8170 ◽  
Author(s):  
Chanmo Park ◽  
Francesco Pagnini ◽  
Andrew Reece ◽  
Deborah Phillips ◽  
Ellen Langer

The current study investigates whether perceived time has an effect on blood glucose level in people with type 2 diabetes. The hypothesis is that perceived time will have a greater influence over blood glucose level than actual time. Changes in blood glucose levels were measured in 46 participants with diabetes while they completed simple tasks during a 90-min period. Participants’ perception of time was manipulated by having them refer to clocks that were either accurate or altered to run fast or slow. Blood glucose levels changed in accordance with how much time they believed had passed instead of how much time had actually passed. These results are an example of the influence psychological processes can directly exert on the body.


2019 ◽  
Vol 1 (1) ◽  
pp. 38-50
Author(s):  
Jumari Jumari ◽  
Agung Waluyo ◽  
Wati Jumaiyah ◽  
Dhea Natashia

However limited study had examined the effect of acupressure to reduce blood glucose levels in patients with type 2 diabetes mellitus. This quasi experimental trial was conducted to identify the effect of acupressure on blood glucose level in patients with type 2 diabetes mellitus. Purposive samples of 32 patients were enrolled. They were divided into intervention (n = 16) and control group (n = 16). Paired t-test have been used to examine the effectiveness of acupressure before and after intervention. The results showed a significant difference in blood glucose levels between the intervention group and the control group (t = 4.22; p = 0.001). Acupressure is an effective intervention to reduce blood glucose levels in patients with type 2 diabetes mellitus. Acupressure can be recommended as one of the independent complementary therapies in nursing care among patient with type 2 diabetes mellitus.   Keywords: Acupressure, Blood Glucose Level, Type 2 Diabetes Mellitus.


2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Musri Musman ◽  
Mauli Zakia ◽  
Ratu Fazlia Inda Rahmayani ◽  
Erlidawati Erlidawati ◽  
Safrida Safrida

Abstract Background Ethnobotany knowledge in a community has shaped local wisdom in utilizing plants to treat diseases, such as the use of Malaka (Phyllanthus emblica) flesh to treat type 2 diabetes. This study presented evidence that the phenolic extract of the Malaka flesh could reduce blood sugar levels in the diabetic induced rats. Methods The phenolic extract of the P. emblica was administrated to the glucose-induced rats of the Wistar strain Rattus norvegicus for 14 days of treatment where the Metformin was used as a positive control. The data generated were analyzed by the two-way ANOVA Software related to the blood glucose level and by SAS Software related to the histopathological studies at a significant 95% confidence. Results The phenolic extract with concentrations of 100 and 200 mg/kg body weight could reduce blood glucose levels in diabetic rats. The post hoc Dunnet test showed that the administration of the extract to the rats with a concentration of 100 mg/kg body weight demonstrated a very significant decrease in blood glucose levels and repaired damaged cells better than administering the extract at a concentration of 200 mg/kg weight body. Conclusion The evidence indicated that the phenolic extract of the Malaka flesh can be utilized as anti type 2 Diabetes mellitus without damaging other organs.


2019 ◽  
Vol 6 (3) ◽  
pp. 786
Author(s):  
Eda Dayakar ◽  
C. Sathya Sree ◽  
E. Sanjay

Background: Diabetes mellitus is a common health problem globally. Dyslipidaemia is a major risk factor to develop cardiovascular disease in diabetics. They present study was undertaken to find out the prevalence of dyslipidaemia in type 2 diabetic patients.Methods: The present study was a cross sectional study consisting of 46 (23 male and 23 female) known type 2 diabetes mellitus patients. Age, gender, duration of diabetes, body mass index (BMI) was recorder in all the diabetic patients.  Fasting blood glucose levels, total cholesterol, triglycerides, HDL, LDL, VLDL levels were measured using standard methods and recorded.Results: The average total cholesterol, triglycerides, LDL, HDL and VLDL were 200±42mg/dl, 169.62±89.79mg/dl, 132.45±36.38mg/dl,39.1±16.6mg/dl and 35.85±17.09mg/dl respectively. The incidence of occurrence of hypercholesterolemia was 58.6% and hypertriglyceridemia 36.9%. Increased levels of LDL were observed in 30 (65.2%) patients and reduced HDL was observed in 43 (93.4%) patients. The incidence rate of dyslipidaemia was higher in female diabetic patients when compared to male diabetic patients.Conclusions: Awareness on the dyslipidaemia and its risk factors should be provided to the type 2 diabetic patients as they are more prone to get cardiovascular disease and lipid profile also should be monitored regularly along with blood glucose levels.


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