scholarly journals Effects of Low-Level Diode Laser on the Level of Interleukin 1-Beta in the Gingival Crevicular Fluid and the Incidence of Gingivitis Caused by the Use of Orthodontic Separators: A Randomized Clinical Trial

2020 ◽  
Vol 12 (4) ◽  
pp. 120-125
Author(s):  
Sepideh Soheilifar ◽  
Sara Soheilifar ◽  
Shayesteh Hatami ◽  
Farshid Vahdatinia ◽  
Vahid Molabashi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Laser Radiation ◽  
Diode Laser ◽  
Orthodontic Treatment ◽  
Gingival Crevicular Fluid ◽  
Interleukin 1 ◽  
Interleukin 1 Beta ◽  
Significant Difference ◽  
Orthodontic Separators ◽  
Crevicular Fluid

Background: In recent years, there has been an increased tendency for using dental lasers for the treatment of soft tissue problems. The aim of this study was to evaluate the effect of low-level diode laser (980 nm) on the level of interleukin 1 beta (IL-1β) in the gingival crevicular fluid (GCF) and the incidence of initial gingivitis caused by the use of orthodontic separators. Methods: In this randomized clinical trial, 30 patients, who were beginning a fixed orthodontic treatment without gingivitis, were randomly assigned to control and diode laser radiation (980 nm wavelength, 3 J of energy, a density of 3 J/cm2 , a power of 0.2 W, and at a distance of 1 cm away from the tissue for 15 seconds on the buccal and palatal sides of the tooth) groups. The gingival index (GI) and bleeding on probing (BOP) were measured at the beginning of the study and one week after the treatment. The level of IL-1β was evaluated using an enzyme-linked immunosorbent assay at the beginning of the study and one week after the placement of the separator. Finally, the inter-group and intra-group statistical analyses were performed using independent and paired t tests, and P<0.05 was considered as the significance level. Results: The evaluation of clinical variables in the entire mouth showed a slight clinical improvement in the experimental group although there was no significant difference between the two groups. No significant difference was observed between intra-group and inter-group evaluations of clinical indices in the studied specific teeth. Eventually, no difference was found between the two groups in terms of IL-1β changes. Conclusions: In general, the single-diode laser radiation session is not effective in the treatment of gingivitis in patients undergoing orthodontic treatment. Thus, it is recommended to perform frequent laser radiation sessions in further studies.

Interleukin-1 beta (IL-1β) levels in gingival crevicular fluid from adults with previous evidence of destructive periodontitis

1992 ◽  
Vol 19 (1) ◽  
pp. 53-57 ◽  
Author(s):  
J. M. A. Wilton ◽  
J. L. Mcpton ◽  
G. S. Griffiths ◽  
M. A. Curtis ◽  
J. S. Life ◽  
...  
Keyword(s):  
Gingival Crevicular Fluid ◽  
Interleukin 1 ◽  
Interleukin 1 Beta ◽  
Previous Evidence ◽  
Crevicular Fluid

scholarly journals Pentraxin-3 Levels in Gingival Crevicular Fluid during Canine Retraction with Nickel–Titanium Coil Spring and Active Tieback

2017 ◽  
Vol 18 (8) ◽  
pp. 710-713
Author(s):  
Sukhpreet Mangat ◽  
Rakesh Thukral ◽  
Anvesha Ganguly ◽  
Harleen Bali ◽  
Shekhar Grover
Keyword(s):  
Orthodontic Treatment ◽  
Gingival Crevicular Fluid ◽  
Nickel Titanium ◽  
Enzyme Linked Immunosorbent Assay ◽  
Pentraxin 3 ◽  
Coil Spring ◽  
Time Intervals ◽  
Canine Retraction ◽  
Significant Difference ◽  
Crevicular Fluid

ABSTRACT Aim Orthodontic treatment is routinely carried out in patients with the purpose of correcting various forms of dental malocclusions. Retraction of the canines can be achieved either individually or along with incisor. Pentraxin-3 (PTX-3) is regarded as the true independent indicator of disease activity. Hence, we undertook the present study to assess and compare the level of PTX-3 in patients undergoing canine retraction with active tieback and Nickel–Titanium (NiTi) coil spring. Materials and methods The present study included assessment of 25 patients that underwent canine retraction as a part of fixed orthodontic treatment. In the maxillary right and left quadrant, active tieback and NiTi coil spring were used respectively. Gingival crevicular fluid samples were collected 1 hour prior to the commencement of orthodontic canine retraction procedure followed by collection at following time intervals: 1 hour, 1, 7, and 14 days after the start of canine retraction procedure. Enzyme-linked immunosorbent assay kit was used for analysis of the samples as per manufacturer's instructions. All the data were recorded and compiled. All the results were analyzed by Statistical Package for the Social Sciences software. Results Nonsignificant difference was observed in the values of PTX-3 at baseline and 1 hour. While comparing the mean PTX-3 values between different time intervals in both the study groups, significant difference was observed. Conclusion In comparison to the active tieback, NiTi coil exhibited faster space closure rate. Clinical significance In patients undergoing orthodontic treatment, PTX-3 is associated with periodontal remodeling under the effect of orthodontic forces. How to cite this article Thukral R, Mangat S, Ganguly A, Agarkar SS, Bali H, Grover S. Pentraxin-3 Levels in Gingival Crevicular Fluid during Canine Retraction with Nickel–Titanium Coil Spring and Active Tieback. J Contemp Dent Pract 2017; 18(8):710-713.

scholarly journals Levels of gingival crevicular fluid matrix metalloproteinases in periodontally compromised teeth under orthodontic forces

2015 ◽  
Vol 85 (6) ◽  
pp. 1009-1014 ◽  
Author(s):  
Rhita C. Almeida ◽  
Jonas Capelli ◽  
Ricardo P. Teles
Keyword(s):  
Matrix Metalloproteinases ◽  
Orthodontic Treatment ◽  
Gingival Crevicular Fluid ◽  
Statistical Tests ◽  
Dental Arch ◽  
Orthodontic Movement ◽  
Significant Difference ◽  
Movement Group ◽  
Crevicular Fluid ◽  
Orthodontic Forces

ABSTRACT Objective:  To examine levels of matrix metalloproteinases (MMPs)-1, -2, -3, -7, -8, -12, and -13 in the gingival crevicular fluid (GCF) of periodontally compromised teeth at different time points during orthodontic movement. Materials and Methods:  Ten controlled periodontitis subjects were submitted to orthodontic treatment. One dental arch was subjected to orthodontic movement, and teeth in the opposite arch were used as controls. GCF samples were collected from the lingual sites of two movement and two control incisors 1 week before orthodontic activation (−7 d), immediately after orthodontic activation, and after 1 hour, 24 hours, and 7, 14, and 21 days. Multiplexed bead immunoassay was used to measure MMPs in GCF. Data were analyzed using Friedman and Wilcoxon statistical tests. Results:  The only significant change found over time was in the levels of MMP-1 in the movement group (P &lt; .05). When the two groups were compared after activation, the only statistically significant difference found was in levels of MMP-12 24 hours after activation (P &lt; .05). Conclusions:  Our findings suggested that the orthodontic movement of periodontally compromised teeth without active pockets did not result in significant changes in the GCF levels of MMPs.

scholarly journals Differences in the gingival crevicular fluid composition between adults and adolescents undergoing orthodontic treatment

2013 ◽  
Vol 84 (1) ◽  
pp. 120-126 ◽  
Author(s):  
Wellington J. Rody ◽  
Manjula Wijegunasinghe ◽  
William A. Wiltshire ◽  
Brenden Dufault
Keyword(s):  
Orthodontic Treatment ◽  
Gingival Crevicular Fluid ◽  
Interleukin 1 ◽  
Age Groups ◽  
Tissue Response ◽  
Fluid Composition ◽  
Age Trends ◽  
Crevicular Fluid ◽  
Changes Over Time ◽  
Microarray Technique

ABSTRACT Objectives: To investigate differences in the gingival crevicular fluid (GCF) composition between adolescent and adult patients undergoing orthodontic treatment with fixed appliances. Materials and Methods: Ten adolescents (14.4 ± 1.43) and 10 adults (28.5 ± 7.83) with Class I malocclusions and minor upper incisor crowding were allocated to two different age groups. Brackets were bonded only in the upper arch over the 20-week period of the experiment. Samples of GCF were collected from the labial sides of the upper incisors (experimental sites) and lower incisors (control sites) of each subject at five time points. Aliquots from diluted GCF were screened for the presence of receptor activator of nuclear factor kappa B ligand (RANKL), osteoprotegerin (OPG), interleukin-1 (IL-1), interleukin-1 receptor antagonist (IL-1RA), and metalloproteinase-9 (MMP-9) using a microarray technique. The values were statistically analyzed. Results: In adults, the ratio of IL-1 to IL-1RA decreased significantly (P  =  .033) in experimental sites 3 weeks after appliance placement and first archwire activation. In adolescents, the ratio of RANKL to OPG peaked 6 weeks after the insertion of the first rectangular archwire. This ratio peak found in adolescents was a consequence of a decrease in the mean concentration of OPG. No significant changes over time were observed in the concentration of MMP-9. Conclusion: This study demonstrates age trends in the GCF levels of IL-1, IL-1RA, RANKL, and OPG that may be used to track differences in tissue response between adults and adolescents undergoing orthodontic treatment.

Effects of Continuous and Interrupted Orthodontic Force on Interleukin-1.BETA. and Interleukin-8 Secretion in Human Gingival Crevicular Fluid

2008 ◽  
Vol 50 (4) ◽  
pp. 230-238
Author(s):  
Chidchanok Leethanakul ◽  
Chuleeporn Kittichaikarn ◽  
Chairat Charoemratrote ◽  
Suwanna Jitpukdeebodintra
Keyword(s):  
Gingival Crevicular Fluid ◽  
Interleukin 1 ◽  
Interleukin 8 ◽  
Interleukin 1 Beta ◽  
Orthodontic Force ◽  
Crevicular Fluid
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