scholarly journals Drug Interactions Among Hospitalized Patients in Intensive Care Units and Infectious Ward, Hamadan, Iran

2018 ◽  
Vol 5 (3) ◽  
pp. 46-51
Author(s):  
Sara Ataei ◽  
Mohammad Jabbari ◽  
Maryam Mehrpooya ◽  
Abbas Taher ◽  
Jalal Poorolajal ◽  
...  
Keyword(s):  
Intensive Care ◽  
Drug Interactions ◽  
Intensive Care Units ◽  
Hospitalized Patients

Drug-drug interactions in Neonatal Intensive Care Units: how to overcome a challenge

2021 ◽  
Vol 73 (2) ◽  
Author(s):  
Kai ROSEN ◽  
Martin H. WIESEN ◽  
André OBERTHÜR ◽  
Guido MICHELS ◽  
Bernd ROTH ◽  
...  
Keyword(s):  
Intensive Care ◽  
Drug Interactions ◽  
Intensive Care Units ◽  
Neonatal Intensive Care ◽  
Neonatal Intensive Care Units

scholarly journals A multicentered pharmacoepidemiological approach to evaluate clinically significant potential drug–drug interactions in medical intensive care settings in Pakistan

2018 ◽  
Vol 25 (4) ◽  
pp. 190-195 ◽  
Author(s):  
Faisal Shakeel ◽  
Jamshaid Ali Khan ◽  
Muhammad Aamir ◽  
Syed Muhammad Asim ◽  
Irfan Ullah
Keyword(s):  
Intensive Care ◽  
Drug Interactions ◽  
Intensive Care Units ◽  
Potential Drug ◽  
Significant Potential ◽  
Significant Difference ◽  
Tertiary Hospitals ◽  
Medical Intensive Care ◽  
Clinically Significant ◽  
Multiple Drugs

Background: Iatrogenic injuries due to drug–drug interactions are particularly significant in critical care units because of the severely compromised state of the patient. The risk further increases with the use of multiple drugs, increasing age, and stay of the patient. Objective: The aim was to assess potential drug–drug interactions, evaluate clinically significant potential drug–drug interactions and their predictors in medical intensive care units of tertiary hospitals in Pakistan. Methods: Analysis of patient data collected from medical intensive care units of tertiary hospitals in Pakistan were carried out using Micromedex DrugReax. Various statistical tools were applied to identify the significance of associated predictors. Results: In a total of 830 patients, prevalence of potential drug–drug interactions was found to be 39%. These attributed to 190 drug combinations, of which 15.4% were clinically significant. A significant association of potential drug–drug interactions was present with number of prescribed drugs, age, and gender. In terms of clinically significant potential drug–drug interactions, the association was significant with increasing age. Moreover, one-way analysis of variance revealed a significant difference in the means of potential drug–drug interactions among the four hospitals. Conclusion: A prevalence of 39% potential drug–drug interactions was observed in patients of medical intensive care unit, with 22.8% being clinically significant. These attributed to nine drug pairs and could easily be avoided to reduce the risk of adverse effects from potential drug–drug interactions.

The prevalence of potentially beneficial and harmful drug-drug interactions in intensive care units

2019 ◽  
Vol 34 (1) ◽  
Author(s):  
Hossein Ali Mehralian ◽  
Jafar Moghaddasi ◽  
Hossein Rafiei
Keyword(s):  
Intensive Care ◽  
Drug Interaction ◽  
Drug Interactions ◽  
Intensive Care Units ◽  
Medical Records ◽  
Potential Ddis ◽  
Cross Sectional ◽  
Text Book ◽  
The Mean ◽  
Potential Interactions

Abstract Background The present study was conducted with the aim of investigating the prevalence of potentially beneficial and harmful drug-drug interactions (DDIs) in intensive care units (ICUs). Methods The present cross-sectional prospective study was conducted in two ICUs in Shahr-e Kord city, Iran. The study sample was consisted of 300 patients. The Drug Interaction Facts reference text book [Tatro DS. Drug interaction facts. St Louis, MO: Walters Kluwer Health, 2010.] was used to determine the type and the frequency of the DDIs. Results The participants consisted of 189 patients men and 111 women. The mean age of patients was 44.2 ± 24.6 years. Totally, 60.5% of patients had at least one drug-drug interaction in their profile. The total number of DDIs found was 663 (the mean of the total number of drug-drug interactions was 2.4 interactions per patient). Of all the 663 interactions, 574 were harmful and others were beneficial. In terms of starting time, 98 of the potential interactions were rapid and 565 of them were delayed. In terms of severity, 511 of the potential interactions were moderate. Some of the drugs in the patients’ medical records including phenytoin, dopamine, ranitidine, corticosteroid, dopamine, heparin, midazolam, aspirin, magnesium, calcium gluconate, and antibiotics, the type of ventilation, the type of nutrition and the duration of hospital stay were among the factors that were associated with high risk of potential DDIs (p < 0.05). Conclusions The prevalence of potentially beneficial and harmful DDIs, especially harmful drug-drug interactions, is high in ICUs and it is necessary to reduce these interactions by implementing appropriate programs and interventions.

Drug-drug interactions in intensive care units and potential clinical consequences of these interactions

2019 ◽  
pp. 1
Author(s):  
Ersoy Oksuz ◽  
Muhammet Bugday ◽  
Celaleddin Soyalp ◽  
Erol Karaaslan ◽  
Gokhan Oto ◽  
...  
Keyword(s):  
Intensive Care ◽  
Drug Interactions ◽  
Intensive Care Units ◽  
Clinical Consequences

scholarly journals Interações medicamentosas em unidades de terapia intensiva do Brasil: Revisão integrativa/ Drug interactions in intensive care units in Brazil: Integrative review

2021 ◽  
Vol 4 (2) ◽  
pp. 7782-7796
Author(s):  
Lucas Henrique de Souza Teixeira ◽  
Michele de Paula Maximo ◽  
André Roberto Machado Vieira ◽  
Laryssa Nathany Ferreira Souza ◽  
Aline Desidério Batista ◽  
...  
Keyword(s):  
Intensive Care ◽  
Drug Interactions ◽  
Intensive Care Units ◽  
Integrative Review ◽  
Terapia Intensiva

scholarly journals Impact of garlic tablets on nosocomial infections in hospitalized patients in intensive care units

10.19082/4064 ◽  
2017 ◽  
Vol 9 (4) ◽  
pp. 4064-4071
Author(s):  
Hossein Madineh ◽  
Farrokh Yadollahi ◽  
Farshad Yadollahi ◽  
Ebrahim Pouria Mofrad ◽  
Majid Kabiri
Keyword(s):  
Intensive Care ◽  
Intensive Care Units ◽  
Nosocomial Infections ◽  
Hospitalized Patients
Sign in / Sign up

Export Citation Format

Share Document