What are the effects of prophylactic pharmacological interventions for preventing delirium in hospitalized patients not in intensive care units?

2016 ◽  
Keyword(s):  
Intensive Care ◽  
Intensive Care Units ◽  
Hospitalized Patients ◽  
Pharmacological Interventions

scholarly journals Drug Interactions Among Hospitalized Patients in Intensive Care Units and Infectious Ward, Hamadan, Iran

2018 ◽  
Vol 5 (3) ◽  
pp. 46-51
Author(s):  
Sara Ataei ◽  
Mohammad Jabbari ◽  
Maryam Mehrpooya ◽  
Abbas Taher ◽  
Jalal Poorolajal ◽  
...  
Keyword(s):  
Intensive Care ◽  
Drug Interactions ◽  
Intensive Care Units ◽  
Hospitalized Patients

scholarly journals Impact of garlic tablets on nosocomial infections in hospitalized patients in intensive care units

10.19082/4064 ◽  
2017 ◽  
Vol 9 (4) ◽  
pp. 4064-4071
Author(s):  
Hossein Madineh ◽  
Farrokh Yadollahi ◽  
Farshad Yadollahi ◽  
Ebrahim Pouria Mofrad ◽  
Majid Kabiri
Keyword(s):  
Intensive Care ◽  
Intensive Care Units ◽  
Nosocomial Infections ◽  
Hospitalized Patients

Pharmacological and non-pharmacological interventions to promote sleep in intensive care units: a critical review

2019 ◽  
Vol 24 (1) ◽  
pp. 25-35 ◽  
Author(s):  
Rogleson Albuquerque Brito ◽  
Soraya Maria do Nascimento Rebouças Viana ◽  
Beatriz Amorim Beltrão ◽  
Clarissa Bentes de Araújo Magalhães ◽  
Veralice Meireles Sales de Bruin ◽  
...  
Keyword(s):  
Intensive Care ◽  
Intensive Care Units ◽  
Critical Review ◽  
Pharmacological Interventions

scholarly journals Present and Future Perspectives on Therapeutic Options for Carbapenemase-Producing Enterobacterales Infections

2021 ◽  
Vol 9 (4) ◽  
pp. 730
Author(s):  
Corneliu Ovidiu Vrancianu ◽  
Elena Georgiana Dobre ◽  
Irina Gheorghe ◽  
Ilda Barbu ◽  
Roxana Elena Cristian ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Intensive Care ◽  
Intensive Care Units ◽  
Hospitalized Patients ◽  
Therapeutic Options ◽  
Future Perspectives ◽  
Carbapenem Resistant ◽  
Geographic Regions

Carbapenem-resistant Enterobacterales (CRE) are included in the list of the most threatening antibiotic resistance microorganisms, being responsible for often insurmountable therapeutic issues, especially in hospitalized patients and immunocompromised individuals and patients in intensive care units. The enzymatic resistance to carbapenems is encoded by different β-lactamases belonging to A, B or D Ambler class. Besides compromising the activity of last-resort antibiotics, CRE have spread from the clinical to the environmental sectors, in all geographic regions. The purpose of this review is to present present and future perspectives on CRE-associated infections treatment.

scholarly journals Carbapenem resistance in non-fermentative bacterial species and in Enterobacteriaceae isolates from hospitalized patients in different health-care settings

2014 ◽  
Vol 87 (4) ◽  
pp. 235-241
Author(s):  
Mihaela Ileana Ionescu ◽  
Dan Stefan Neagoe ◽  
Claudia Chiorean ◽  
Loredana Dumitras ◽  
Aurelia Rus
Keyword(s):  
Health Care ◽  
Pseudomonas Aeruginosa ◽  
Intensive Care ◽  
Intensive Care Units ◽  
Carbapenem Resistance ◽  
Hospitalized Patients ◽  
Health Care Settings ◽  
Carbapenem Resistant ◽  
Acinetobacter Spp ◽  
Resistant Strains

Aim. Carbapenem-resistant strains have been increasingly reported over the last few years. In this study  we used laboratory records to determine the occurrence of carbapenem-resistant strains from hospitalized patients with emphasis on the comparative analysis of the incidence in various health-care settings. Materials and methods. From January 2012 to November 2012 and from May 2013 to November 2013, we evaluated 566 strains (Acinetobacter spp., Pseudomonas aeruginosa, Escherichia coli, and Klebsiella spp.). All isolates were tested and analyzed according to their antibiotic resistance phenotypic pattern. Laboratory results were correlated with data regarding admission in different clinical wards.Results. Among 566 isolates, 191 carbapenem-resistant or carbapenem-intermediate strains (33.74%) were detected. Non-fermentative species were the most prevalent carbapenem-resistant organisms, 80.62% of 191 carbapenem-resistant or carbapenem-intermediate strains isolated were Acinetobacter spp., and 17.27% of 191 were Pseudomonas aeruginosa. Apart from that, only 4 (2.09%) carbapenem-resistant Enterobacteriaceae (CRE) strains were identified. We identified 59.30% of 172 strains isolated from patients hospitalized in anesthesia and intensive care units non-susceptible to carbapenems. The main mechanism associated with carbapenem resistance could be the production of carbapenemase in combination with impermeability.Conclusions. Our study demonstrates that infections with carbapenem-resistant strains are correlated with hospitalization in intensive care units. Our data showed a predominant carbapenem-resistant Acinetobacter spp. strain in intensive care units.

scholarly journals The effect of COVID-19 on critical care research: A prospective longitudinal multinational survey

2020 ◽  
Author(s):  
Mark Duffett ◽  
Deborah J Cook ◽  
Geoff Strong ◽  
Jan Hau Lee ◽  
Michelle E Kho
Keyword(s):  
Critical Care ◽  
Intensive Care ◽  
Infection Control ◽  
Clinical Research ◽  
Intensive Care Units ◽  
Pediatric Intensive Care ◽  
Hospitalized Patients ◽  
Research Activity ◽  
Pediatric Intensive Care Units ◽  
Over Time

AbstractImportanceThe COVID-19 pandemic has increased the need for high-quality evidence in critical care, while also increasing the barriers to conducting the research needed to produce such evidence.ObjectiveTo determine the effect of the first wave of the COVID-19 pandemic on critical care clinical research.DesignMonthly electronic survey (March - August 2020).SettingAdult or pediatric intensive care units (ICUs) from any country participating in at least one research study before the COVID-19 pandemic.ParticipantsWe recruited one researcher or research coordinator per center, identified via established research networks.Intervention(s)NoneMain Outcome(s) and Measure(s)Primary: Suspending recruitment in clinical research; Secondary: impact of specific factors on research conduct (5-point scales from no effect to very large effect). We assessed the association between research continuity and month, presence of hospitalized patients with COVID-19, and population (pediatric vs. adult ICU) using mixed-effects logistic regression.Results126 centers (56% pediatric) from 23 countries participated. 95 (75%) of centers suspended recruitment in at least some studies and 37 (29%) suspended recruitment in all studies on at least one month. The proportion of centers reporting recruitment in all studies increased over time (OR per month 1.3, 95% CI 1.1 to 1.5, p = 0.007), controlling for hospitalized patients with COVID-19 and type of ICU (pediatric vs. other). The five factors most frequently identified as having a large or very large effect on clinical research were: local prioritization of COVID-19 specific research (68, 54%), infection control policies limiting access to patients with COVID-19 (61, 49%), infection control policies limiting access to the ICU (52, 41.6%), increased workload of clinical staff (38, 30%), and safety concerns of research staff (36, 29%).Conclusions and RelevanceDecisions to pause or pursue clinical research varied across centers. Research activity increased over time, despite the presence of hospitalized patients with COVID-19. Guiding principles to safely sustain research during this and future pandemic waves are urgently needed.Key PointsQuestionWhat was the effect of the COVID-19 pandemic on research in 126 adult and pediatric intensive care units (ICUs) between March and August 2020? Findings95 (75%) centers suspended recruitment in at least some studies. Decisions to continue recruitment increased over time (OR per month 1.3, 95% CI 1.1 to 1.5, p = 0.007), controlling for ICU type and the presence of patients with COVID-19.MeaningResearch activity varied across centers and increased over time, despite the presence of hospitalized patients with COVID-19. Guiding principles to safely sustain research during this and future pandemic waves are urgently needed.

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