scholarly journals Risk Factors Associated with Heart Valve Thrombosis in Patients with Prosthetic Heart Valve Dysfunction

2020 ◽  
Vol 23 (9) ◽  
pp. 600-604
Author(s):  
Feridoun Noohi Bezanjani ◽  
Sepehr Gohari ◽  
Hossein Ali Bassiri ◽  
Hassan Ahangar ◽  
Tara Reshadmanesh
Keyword(s):  
Heart Valve ◽  
Prosthetic Valve ◽  
Fibrinogen Level ◽  
Laboratory Data ◽  
Prosthetic Heart Valve ◽  
Plasma Fibrinogen ◽  
Plasma Fibrinogen Level ◽  
Valve Thrombosis ◽  
History Of ◽  
Heart Valve Thrombosis

Background: Thrombotic and thromboembolic events are important causes of mortality and morbidity in patients with prosthetic heart valve. The aim of this study is to evaluate the factors that may contribute to prosthetic heart valve thrombosis. Methods: This was a cross-sectional study in Rajaie Heart Center on patients with prosthetic heart valve malfunction, within a year. According to the echocardiographic and fluoroscopic findings, the patients were divided into two groups (thrombosis and non-thrombosis groups). The patients’ demographic, clinical and laboratory data were recorded and analyzed with SPSS software. Results: A total of 142 patients participated in this study. Ninety-four patients (66.2%) were diagnosed with thrombosis. There was a significant relationship between thrombosis and inadequate anti-coagulation (international normalized rati [INR] <2.5) (odds ratio [OR]: 4.15, 95% CI: 1.98-9.87, P = 0.003), history of infection (OR: 12.81, 95% CI: 3.52-19.02, P<0.001), prothrombin time (PT) check interval (OR: 2.38, 95% CI: 1.63-8.47, P = 0.019), atrial fibrillation (AF) rhythm (OR: 3.96, 95% CI: 1.75-8.09, P = 0.019), and plasma fibrinogen level (OR: 6.90, 95% CI: 2.58-14.69). Conclusion: Based on this study, inadequate anti-coagulation, AF rhythm, recent infection and plasma fibrinogen level were the factors most contributing to prosthetic valve thrombosis. As there were many cases of thrombosis in patients with history of infection, this factor can be considered for risk assessment in prosthetic valve.

Unusual presentation of mitral prosthetic heart valve thrombosis managed with low dose tenecteplase infusion

2021 ◽  
pp. 1-3
Author(s):  
A. Shaheer Ahmed ◽  
Shivank Gupta
Keyword(s):  
Prosthetic Valve ◽  
Low Dose ◽  
Prosthetic Heart Valve ◽  
Low Grade ◽  
Prosthetic Valve Thrombosis ◽  
Echocardiographic Evaluation ◽  
Dose Infusion ◽  
Valve Thrombosis ◽  
History Of ◽  
Heart Valve Thrombosis

Abstract A 11-year-old with history of mitral valve replacement presented with low-grade fever, breathlessness and multiple episodes of haemoptysis for 2 days. Detailed echocardiographic evaluation revealed possible prosthetic valve thrombosis, which was confirmed by fluoroscopy. She was thrombolysed with low dose infusion of tenecteplase. Post thrombolysis her symptoms improved, valve mobility was restored, and haemoptysis subsided. Left sided prosthetic valve thrombosis presenting predominantly with haemoptysis is very rare.

Fatal Cerebral Hemorrhage Complicating Thromboembolic Stroke in a Patient with Prosthetic Mitral Valve Thrombosis Treated with Thrombolytic Therapy

1997 ◽  
Vol 3 (4) ◽  
pp. 290-293 ◽  
Author(s):  
Fabio Barbero ◽  
Vittorio Pengo ◽  
Giuseppe Fasoli
Keyword(s):  
Mitral Valve ◽  
Thrombolytic Therapy ◽  
Heart Valve ◽  
Prosthetic Heart Valve ◽  
Recombinant Tissue Plasminogen Activator ◽  
Key Words Heart ◽  
Valve Thrombosis ◽  
Hemorrhagic Risk ◽  
History Of ◽  
Heart Valve Thrombosis

We report the case of a 66-year-old male with a history of mitral valve replacement with a Sorin tilting-disk prosthesis and a subsequent operation for severe constrictive pericarditis. After 5 years of stable anticoagulant treatment, he suffered an intracerebral hemorrhage that required temporary withdrawal of warfarin. Thrombosis of the prosthesis, presenting as acute heart failure, was then determined. Due to high-operative and hemorrhagic risk, the patient was treated with low-dose thrombolytic therapy administered as two boluses of recombinant tissue plasminogen activator (r-tPA). The patient's hemodynamics improved strikingly. However, a few hours after the second dose, a devastating cerebral hemorrhagic infarction resulted in death. Autopsy showed the primarily ischemic nature of both strokes. The schemes of thrombolytic therapy in prosthetic heart valve thrombosis and the importance of a correct interpretation of pathogenesis of stroke in anticoagulated patients are discussed. Key Words: Heart valve thrombosis— Thrombolysis—Stroke—Warfarin.

Variation in the Promoter Region of the β Fibrinogen Gene Is Associated with Plasma Fibrinogen Levels in Smokers and Non-Smokers

1991 ◽  
Vol 65 (05) ◽  
pp. 487-490 ◽  
Author(s):  
A E Thomas ◽  
F R Green ◽  
C H Kelleher ◽  
H C Wilkes ◽  
P J Brennan ◽  
...  
Keyword(s):  
Heart Disease ◽  
Promoter Region ◽  
Fragment Length Polymorphism ◽  
Fibrinogen Level ◽  
Plasma Fibrinogen ◽  
Plasma Fibrinogen Level ◽  
Healthy Men ◽  
History Of ◽  
General Practices ◽  
Restriction Fragment Length

SummaryWe investigated the association between fibrinogen levels and a HaeIII restriction fragment length polymorphism located at −453 bp from the start of transcription of the β fibrinogen gene. 292 healthy men aged 45 to 69 years, recruited from general practices throughout Britain, were studied. None had a history of ischaemic heart disease. 41.1% (120) were smokers and fibrinogen levels were higher in this group. The frequency of the noncutting allele (designated H2) was 0.19 and was the same in smokers and non-smokers. The H2 allele was associated with elevated levels of fibrinogen in both smokers and non-smokers and the effect of genotype was similar in both groups. After smoking, HaeIII genotype was the strongest predictor of fibrinogen levels and explained 3.1% of the variance in fibrinogen levels. These results confirm earlier studies that variation at the fibrinogen locus contributes to the between-individual differences in plasma fibrinogen level.

Comparison of Thrombolysis Versus Surgery as a First Line Therapy for Prosthetic Heart Valve Thrombosis

2011 ◽  
Vol 107 (2) ◽  
pp. 275-279 ◽  
Author(s):  
Siegmund Keuleers ◽  
Paul Herijgers ◽  
Marie-Christine Herregods ◽  
Werner Budts ◽  
Christophe Dubois ◽  
...  
Keyword(s):  
Heart Valve ◽  
Prosthetic Heart Valve ◽  
First Line ◽  
First Line Therapy ◽  
Line Therapy ◽  
Valve Thrombosis ◽  
Heart Valve Thrombosis

Thrombolysis as first choice therapy in prosthetic heart valve thrombosis. A study of 68 patients

2006 ◽  
Vol 21 (2) ◽  
pp. 185-190 ◽  
Author(s):  
Fidel Manuel Cáceres-Lóriga ◽  
Horacio Pérez-López ◽  
Karel Morlans-Hernández ◽  
Humberto Facundo-Sánchez ◽  
José Santos-Gracia ◽  
...  
Keyword(s):  
Heart Valve ◽  
Prosthetic Heart Valve ◽  
First Choice ◽  
Valve Thrombosis ◽  
Heart Valve Thrombosis

Safety of thrombolytic therapy in patients with prosthetic heart valve thrombosis who have high international normalized ratio levels

2020 ◽  
Vol 35 (10) ◽  
pp. 2522-2528 ◽  
Author(s):  
Khadijeh Farzaneh ◽  
Seyedeh Hamideh Mortazavi ◽  
Alireza Oraii ◽  
Kyomars Abbasi ◽  
Abbas Salehi Omran ◽  
...  
Keyword(s):  
Thrombolytic Therapy ◽  
Heart Valve ◽  
Prosthetic Heart Valve ◽  
International Normalized Ratio ◽  
Valve Thrombosis ◽  
Heart Valve Thrombosis
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