Safety of thrombolytic therapy in patients with prosthetic heart valve thrombosis who have high international normalized ratio levels

2020 ◽  
Vol 35 (10) ◽  
pp. 2522-2528 ◽  
Author(s):  
Khadijeh Farzaneh ◽  
Seyedeh Hamideh Mortazavi ◽  
Alireza Oraii ◽  
Kyomars Abbasi ◽  
Abbas Salehi Omran ◽  
...  
Keyword(s):  
Thrombolytic Therapy ◽  
Heart Valve ◽  
Prosthetic Heart Valve ◽  
International Normalized Ratio ◽  
Valve Thrombosis ◽  
Heart Valve Thrombosis

Fatal Cerebral Hemorrhage Complicating Thromboembolic Stroke in a Patient with Prosthetic Mitral Valve Thrombosis Treated with Thrombolytic Therapy

1997 ◽  
Vol 3 (4) ◽  
pp. 290-293 ◽  
Author(s):  
Fabio Barbero ◽  
Vittorio Pengo ◽  
Giuseppe Fasoli
Keyword(s):  
Mitral Valve ◽  
Thrombolytic Therapy ◽  
Heart Valve ◽  
Prosthetic Heart Valve ◽  
Recombinant Tissue Plasminogen Activator ◽  
Key Words Heart ◽  
Valve Thrombosis ◽  
Hemorrhagic Risk ◽  
History Of ◽  
Heart Valve Thrombosis

We report the case of a 66-year-old male with a history of mitral valve replacement with a Sorin tilting-disk prosthesis and a subsequent operation for severe constrictive pericarditis. After 5 years of stable anticoagulant treatment, he suffered an intracerebral hemorrhage that required temporary withdrawal of warfarin. Thrombosis of the prosthesis, presenting as acute heart failure, was then determined. Due to high-operative and hemorrhagic risk, the patient was treated with low-dose thrombolytic therapy administered as two boluses of recombinant tissue plasminogen activator (r-tPA). The patient's hemodynamics improved strikingly. However, a few hours after the second dose, a devastating cerebral hemorrhagic infarction resulted in death. Autopsy showed the primarily ischemic nature of both strokes. The schemes of thrombolytic therapy in prosthetic heart valve thrombosis and the importance of a correct interpretation of pathogenesis of stroke in anticoagulated patients are discussed. Key Words: Heart valve thrombosis— Thrombolysis—Stroke—Warfarin.

Comparison of Thrombolysis Versus Surgery as a First Line Therapy for Prosthetic Heart Valve Thrombosis

2011 ◽  
Vol 107 (2) ◽  
pp. 275-279 ◽  
Author(s):  
Siegmund Keuleers ◽  
Paul Herijgers ◽  
Marie-Christine Herregods ◽  
Werner Budts ◽  
Christophe Dubois ◽  
...  
Keyword(s):  
Heart Valve ◽  
Prosthetic Heart Valve ◽  
First Line ◽  
First Line Therapy ◽  
Line Therapy ◽  
Valve Thrombosis ◽  
Heart Valve Thrombosis

Thrombolysis as first choice therapy in prosthetic heart valve thrombosis. A study of 68 patients

2006 ◽  
Vol 21 (2) ◽  
pp. 185-190 ◽  
Author(s):  
Fidel Manuel Cáceres-Lóriga ◽  
Horacio Pérez-López ◽  
Karel Morlans-Hernández ◽  
Humberto Facundo-Sánchez ◽  
José Santos-Gracia ◽  
...  
Keyword(s):  
Heart Valve ◽  
Prosthetic Heart Valve ◽  
First Choice ◽  
Valve Thrombosis ◽  
Heart Valve Thrombosis

Prosthetic heart valve thrombosis: Pathogenesis, diagnosis and management

2006 ◽  
Vol 110 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Fidel Manuel Cáceres-Lóriga ◽  
Horacio Pérez-López ◽  
José Santos-Gracia ◽  
Karel Morlans-Hernandez
Keyword(s):  
Heart Valve ◽  
Prosthetic Heart Valve ◽  
Diagnosis And Management ◽  
Valve Thrombosis ◽  
Heart Valve Thrombosis
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