Clinical outcomes of adjuvant external-beam radiotherapy for differentiated thyroid cancer

2009 ◽  
Vol 48 (03) ◽  
pp. 89-98 ◽  
Author(s):  
M. K. Pixberg ◽  
B. Riemann ◽  
A. Schuck ◽  
A. Heinecke ◽  
K. W. Schmid ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Differentiated Thyroid Cancer ◽  
Regional Lymph Node ◽  
Statistical Significance ◽  
External Beam Radiotherapy ◽  
Distant Metastases ◽  
External Beam ◽  
Node Metastases

Summary Aim: Evaluate the clinical benefit of external beam radiotherapy (RTx) for locally invasive thyroid carcinoma with follicular cell differentiation (DTC). Patients, methods: The Multicentre Study on Differentiated Thyroid Cancer (MSDS) was planned as a prospective multicenter trial on the benefit of adjuvant RTx in locally invasive DTC (pT4; UICC 1997) with or without lymph node metastases and no known distant metastases. All patients were treated with thyroidectomy, 131I-therapy, and TSH-suppression and were randomized to receive additional RTx or not. In 4/2003 the trial became a prospective cohort study after only 45 of then 311 patients had consented to randomization. 351 of 422 patients met the trial's inclusion criteria. Age was 48 ± 12 years (mean ± SD). 25% were men. Tumours were papillary in 90% and follicular in 10%. Of 47 patients randomized or allocated to RTx, 26 actually received RTx. Results: Mean followup was 930 days. In an actual treatment analysis, 96% (25/26) of the RTx-patients reached complete remission (CR) vs. 86% in the non-RTx patients. Recurrences occurred in 0 vs. 3 % of patients: 6 reoperated for regional lymph node metastases, 1 tracheal invasion treated with tracheoplasty, 1 local invasion necessitating laryngectomy, 2 distant metastases (1 lung, 1 lung + bone). Serious chronic RTx toxicity occurred in 1/26 patients. Conclusion: The MSDS trial showed low mortality and recurrence rates and a weak benefit of RTx in terms of local control that did however not reach statistical significance. Routine RTx in locally invasive DTC can no longer be recommended .

Practical Initial Risk Stratification Based on Lymph Node Metastases in Pediatric and Adolescent Differentiated Thyroid Cancer

Thyroid ◽  
2018 ◽  
Vol 28 (2) ◽  
pp. 193-200 ◽  
Author(s):  
Min Ji Jeon ◽  
Young Nam Kim ◽  
Tae-Yong Sung ◽  
Suck Joon Hong ◽  
Yoon Young Cho ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Risk Stratification ◽  
Lymph Node Metastases ◽  
Differentiated Thyroid Cancer ◽  
Node Metastases

Lymph node metastases in differentiated thyroid cancer under 2 cm

Surgery ◽  
2006 ◽  
Vol 140 (6) ◽  
pp. 1050-1055 ◽  
Author(s):  
Rishindra M. Reddy ◽  
Perry W. Grigsby ◽  
Jeffrey F. Moley ◽  
Bruce L. Hall
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Differentiated Thyroid Cancer ◽  
Node Metastases

scholarly journals Iodine-131: An Effective Method for Treating Lymph Node Metastases of Differentiated Thyroid Cancer

2016 ◽  
Vol 22 ◽  
pp. 4924-4928 ◽  
Author(s):  
Ying He ◽  
Ming-zhi Pan ◽  
Jian-min Huang ◽  
Peng Xie ◽  
Fang Zhang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Differentiated Thyroid Cancer ◽  
Node Metastases ◽  
Iodine 131

scholarly journals Prognostic value of lymph node metastases of differentiated thyroid cancer (DTC) according to the local advancement and range of surgical excision

2010 ◽  
Vol 3 (1) ◽  
pp. 8 ◽  
Author(s):  
Agnieszka Czarniecka ◽  
Michal Jarzab ◽  
Jolanta Krajewska ◽  
Ewa Chmielik ◽  
Bogna Szcześniak-Klusek ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Prognostic Value ◽  
Differentiated Thyroid Cancer ◽  
Surgical Excision ◽  
Node Metastases

PAPILLARY THYROID CARCINOMA IN CHILDREN AND ADOLESCENTS, RESULTS OF TREATMENT OF 215 PATIENTS: FACTORS PREDICTING DISTANT METASTASES AND RECURRENCE OF THE DISEASE

2018 ◽  
Vol 64 (6) ◽  
pp. 752-757
Author(s):  
Aleksey Ilin ◽  
Dmitriy Semin ◽  
Pavel Isaev ◽  
Natalya Severskaya ◽  
Feliks Sevryukov ◽  
...  
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Lymph Node Metastases ◽  
Lung Metastases ◽  
Regional Lymph Node ◽  
Distant Metastases ◽  
Papillary Thyroid ◽  
Results Of Treatment ◽  
Node Metastases ◽  
Risk Of Relapse

We evaluated the results of treatment of 215 pediatric patients with papillary thyroid carcinoma (PTC). Median age at diagnosis was 14 (5 - 18 y.o). Thyroidectomy performed in 105, subtotalthyroidectomy in 8, lobectomy - in 102, additional lymph node dissection - in 169, radioiodine ablation/ therapy - in 102 patients. Follicular variant PTC was found in 41 (19%), solid - in 37 (17%), diffuse sclerosing - in 3 (1%), the remaining had a classical PTC with mainly papillary (90; 42%) or follicular (44; 21%) pattern. 21% had multifocal PTC, 4,6% - extrathyroidal extension, 62% - regional lymph node metastases, 12% - lung metastases. The follow up was 95 months (6 - 301 mo). All patients are alive. Recurrence of PTC occurred in 37 (17%): 7 - thyroid remnant, 26 - cervical lymph nodes, 4 - distant lung metastases. Prognostic factors for distant metastases were young age at diagnosis <12 years old (OR 3.4, р <0.022), tumor size more then 3 cm (OR 3.2, р <0.027) and lateral cervical lymph node metastases (OR 21.39, р <0.0001). Risk of recurrence was higher in multifocal PTC (OR 2.4, р <0.009), regional lymph node metastases (OR 7.4, р <0,008) and distant metastases (OR 3.2, р <0,01). The highest risk of relapse had the patients with solid variant of PTC. Radical surgery diminished the risk of relapse (OR 0.3, р <0.002). There was no evidence of impact of radioiodine therapy on risk of recurrence (р=0.66).

scholarly journals Evolution of differentiated thyroid cancer during pregnancy in a community University Hospital in Buenos Aires, Argentina

2013 ◽  
Vol 57 (4) ◽  
pp. 307-311 ◽  
Author(s):  
Carmen Amalia Cabezón ◽  
Laura Carolina Carrizo ◽  
Pablo René Costanzo
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Tumor Size ◽  
Differentiated Thyroid Cancer ◽  
Whole Body ◽  
Group I ◽  
Node Metastases ◽  
Group Ii

OBJECTIVE: To analyze the presentation, follow-up and evolution of differentiated thyroid cancer (DTC) detected during pregnancy. SUBJECTS AND METHODS: Twenty nine women with DTC detected during pregnancy were analyzed. Group I (n = 13) was seen during pregnancy and DTC was diagnosed during gestation; detection of the nodule occurred during pregnancy (first trimester). Group II (n = 16) was seen after delivery; detection of the nodule occurred during pregnancy (second or third trimester). Complete thyroidectomy, ablative dose of radioactive iodine, and treatment with levothyroxine were performed. Follow-up: neck ultrasound; TSH, free T4, thyroglobulin, and anti-thyroglobulin antibodies with and without treatment with levothyroxine; and 131I whole body scans. Histological diagnosis, lymph node metastases, tumor size and stage, complications from pregnancy, and DTC evolution were evaluated. RESULTS: 100% of the patients had papillary thyroid carcinoma. Lymph node metastases were detected in 13 (44.8%), and invasion of adjacent extrathyroid tissue in 2 patients. Tumor size was larger in Group II: 22.1 ± 10.9 versus 13.9 ± 3.5 mm; p = 0.03. No differences were found in the tumor stages between groups. All patients had full-term pregnancies and healthy newborns. Follow-up: 5.7 ± 4.3 years; one patient had persistent disease. CONCLUSIONS: DTC detected during pregnancy had a favorable evolution. Surgery may be postponed to the post-delivery period, unless there are risk factors that justify it during pregnancy.

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