Practical Initial Risk Stratification Based on Lymph Node Metastases in Pediatric and Adolescent Differentiated Thyroid Cancer

Thyroid ◽  
2018 ◽  
Vol 28 (2) ◽  
pp. 193-200 ◽  
Author(s):  
Min Ji Jeon ◽  
Young Nam Kim ◽  
Tae-Yong Sung ◽  
Suck Joon Hong ◽  
Yoon Young Cho ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Risk Stratification ◽  
Lymph Node Metastases ◽  
Differentiated Thyroid Cancer ◽  
Node Metastases

Clinical outcomes of adjuvant external-beam radiotherapy for differentiated thyroid cancer

2009 ◽  
Vol 48 (03) ◽  
pp. 89-98 ◽  
Author(s):  
M. K. Pixberg ◽  
B. Riemann ◽  
A. Schuck ◽  
A. Heinecke ◽  
K. W. Schmid ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Differentiated Thyroid Cancer ◽  
Regional Lymph Node ◽  
Statistical Significance ◽  
External Beam Radiotherapy ◽  
Distant Metastases ◽  
External Beam ◽  
Node Metastases

Summary Aim: Evaluate the clinical benefit of external beam radiotherapy (RTx) for locally invasive thyroid carcinoma with follicular cell differentiation (DTC). Patients, methods: The Multicentre Study on Differentiated Thyroid Cancer (MSDS) was planned as a prospective multicenter trial on the benefit of adjuvant RTx in locally invasive DTC (pT4; UICC 1997) with or without lymph node metastases and no known distant metastases. All patients were treated with thyroidectomy, 131I-therapy, and TSH-suppression and were randomized to receive additional RTx or not. In 4/2003 the trial became a prospective cohort study after only 45 of then 311 patients had consented to randomization. 351 of 422 patients met the trial's inclusion criteria. Age was 48 ± 12 years (mean ± SD). 25% were men. Tumours were papillary in 90% and follicular in 10%. Of 47 patients randomized or allocated to RTx, 26 actually received RTx. Results: Mean followup was 930 days. In an actual treatment analysis, 96% (25/26) of the RTx-patients reached complete remission (CR) vs. 86% in the non-RTx patients. Recurrences occurred in 0 vs. 3 % of patients: 6 reoperated for regional lymph node metastases, 1 tracheal invasion treated with tracheoplasty, 1 local invasion necessitating laryngectomy, 2 distant metastases (1 lung, 1 lung + bone). Serious chronic RTx toxicity occurred in 1/26 patients. Conclusion: The MSDS trial showed low mortality and recurrence rates and a weak benefit of RTx in terms of local control that did however not reach statistical significance. Routine RTx in locally invasive DTC can no longer be recommended .

Lymph node metastases in differentiated thyroid cancer under 2 cm

Surgery ◽  
2006 ◽  
Vol 140 (6) ◽  
pp. 1050-1055 ◽  
Author(s):  
Rishindra M. Reddy ◽  
Perry W. Grigsby ◽  
Jeffrey F. Moley ◽  
Bruce L. Hall
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Differentiated Thyroid Cancer ◽  
Node Metastases

scholarly journals Iodine-131: An Effective Method for Treating Lymph Node Metastases of Differentiated Thyroid Cancer

2016 ◽  
Vol 22 ◽  
pp. 4924-4928 ◽  
Author(s):  
Ying He ◽  
Ming-zhi Pan ◽  
Jian-min Huang ◽  
Peng Xie ◽  
Fang Zhang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Differentiated Thyroid Cancer ◽  
Node Metastases ◽  
Iodine 131

scholarly journals Prognostic value of lymph node metastases of differentiated thyroid cancer (DTC) according to the local advancement and range of surgical excision

2010 ◽  
Vol 3 (1) ◽  
pp. 8 ◽  
Author(s):  
Agnieszka Czarniecka ◽  
Michal Jarzab ◽  
Jolanta Krajewska ◽  
Ewa Chmielik ◽  
Bogna Szcześniak-Klusek ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Prognostic Value ◽  
Differentiated Thyroid Cancer ◽  
Surgical Excision ◽  
Node Metastases

scholarly journals Evolution of differentiated thyroid cancer during pregnancy in a community University Hospital in Buenos Aires, Argentina

2013 ◽  
Vol 57 (4) ◽  
pp. 307-311 ◽  
Author(s):  
Carmen Amalia Cabezón ◽  
Laura Carolina Carrizo ◽  
Pablo René Costanzo
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Tumor Size ◽  
Differentiated Thyroid Cancer ◽  
Whole Body ◽  
Group I ◽  
Node Metastases ◽  
Group Ii

OBJECTIVE: To analyze the presentation, follow-up and evolution of differentiated thyroid cancer (DTC) detected during pregnancy. SUBJECTS AND METHODS: Twenty nine women with DTC detected during pregnancy were analyzed. Group I (n = 13) was seen during pregnancy and DTC was diagnosed during gestation; detection of the nodule occurred during pregnancy (first trimester). Group II (n = 16) was seen after delivery; detection of the nodule occurred during pregnancy (second or third trimester). Complete thyroidectomy, ablative dose of radioactive iodine, and treatment with levothyroxine were performed. Follow-up: neck ultrasound; TSH, free T4, thyroglobulin, and anti-thyroglobulin antibodies with and without treatment with levothyroxine; and 131I whole body scans. Histological diagnosis, lymph node metastases, tumor size and stage, complications from pregnancy, and DTC evolution were evaluated. RESULTS: 100% of the patients had papillary thyroid carcinoma. Lymph node metastases were detected in 13 (44.8%), and invasion of adjacent extrathyroid tissue in 2 patients. Tumor size was larger in Group II: 22.1 ± 10.9 versus 13.9 ± 3.5 mm; p = 0.03. No differences were found in the tumor stages between groups. All patients had full-term pregnancies and healthy newborns. Follow-up: 5.7 ± 4.3 years; one patient had persistent disease. CONCLUSIONS: DTC detected during pregnancy had a favorable evolution. Surgery may be postponed to the post-delivery period, unless there are risk factors that justify it during pregnancy.

scholarly journals Surgery and Radioactive Iodine Therapeutic Strategy for Patients Greater than 60 Years of Age with Differentiated Thyroid Cancer

2020 ◽  
Author(s):  
Tao Tang ◽  
Wei Zhang ◽  
Jingtai Zhi ◽  
Xianhui Ruan ◽  
Linfei Hu ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Surgical Treatment ◽  
Total Thyroidectomy ◽  
Lymph Node Metastases ◽  
Differentiated Thyroid Cancer ◽  
Surgery Group ◽  
Risk Patients ◽  
Node Metastases ◽  
Cause Specific Survival

AbstractPurposeThe purpose of the current study was to determine whether older patients with differentiated thyroid cancer (DTC) who received surgical treatment had a better cause-specific survival (CSS) than patients who were recommended surgery, but declined, and whether patients who underwent post-operative RAI-131 therapy had an impact on CSS based on TNM staging and number of lymph node metastases for all total or near-total thyroidectomy patients.Patients and MethodsAll DTC patients information were obtained from the SEER*Stat 8.3.6 program, and only patients ≥ 60 years or older were considered. The patients were divided into two groups (underwent surgery and surgery recommend, but not performed). Furthermore, patients were grouped as follows: T4; N1b; M1; T1-3N0-1a; specific number of lymph node metastases; and total or near-total thyroidectomy.ResultsThe 120-month cause-specific survival (CSS) rate of females and males showed a gradual declining trend from 60-64 to ≥80 years of age in the group that underwent surgery. The CSS rate of females and males showed a marked downward and irregular trend with an increase in age in the recommended, but no surgery group. Univariate analysis indicated that the surgery group had a higher 120-month CSS in females in most stages and males, compared with the no surgery group. RAI-131 therapy was associated with an improved 80-month CSS in T4/N1b/M1 females (P<0.0183) and males (P<0.0011). There was no CSS difference in females or males between the T1-3N0 and T1-3N1a patients. There was no statistical difference between the two subgroups.ConclusionsSurgical treatment should be recommended for elderly DTC patients because surgery can lead to a better CSS. High-risk patients achieve a higher benefit-to-risk ratio with RAI-131 therapy. To avoid the adverse effects associated with RAI-131 therapy, a multidisciplinary discussion should be arranged for intermediate- and low-risk patients.

Lymph node metastases from well-differentiated thyroid cancer

1985 ◽  
Vol 149 (5) ◽  
pp. 610-612 ◽  
Author(s):  
Gregor I. McGregor ◽  
Andrew Luoma ◽  
Stewart M. Jackson
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Differentiated Thyroid Cancer ◽  
Node Metastases ◽  
Well Differentiated
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