Molecular genetic studies on virulence-associated chromosomal loci of Shigella flexneri 2a.

1993 ◽  
Vol 48 (6) ◽  
pp. 729-738
Author(s):  
Nobuhiko OKADA
Keyword(s):  
Shigella Flexneri ◽  
Molecular Genetic ◽  
Genetic Studies ◽  
Shigella Flexneri 2A ◽  
Chromosomal Loci

scholarly journals Genes, environment and schizophrenia

2001 ◽  
Vol 178 (S40) ◽  
pp. s18-s24 ◽  
Author(s):  
Ming T. Tsuang ◽  
William S. Stone ◽  
Stephen V. Faraone
Keyword(s):  
Genetic Factors ◽  
Molecular Genetic ◽  
Treatment Strategies ◽  
Adoption Studies ◽  
Genetic Studies ◽  
Neurodevelopmental Model ◽  
Overwhelming Evidence ◽  
Representative Selection ◽  
Chromosomal Loci ◽  
Selection Of

BackgroundData from family, twin and adoption studies show overwhelming evidence of a substantial genetic component in schizophrenia and although molecular genetic studies have been more difficult to replicate, recent improvements in technology have resulted in the implication of genes at several chromosomal loci. Nevertheless, it remains clear that environmental factors both add to and interact with genetic factors to produce the disorder.AimsTo incorporate genetic and environmental risk factors into a neurodevelopmental model in order to conceptualise the liability to schizophrenia.MethodA representative selection of the literature related to this issue is reviewed, together with a reformulation of Meehl's term ‘schizotaxia’ to describe the liability to the disorder.ResultsThe literature supports a multi-factorial view of the liability to schizophrenia, which includes both genetic and environmental components.ConclusionsSchizotaxia provides a useful way to conceptualise both the liability for schizophrenia, and also the development of treatment strategies aimed at the eventual prevention of the illness.

scholarly journals Prospects for the Personalized Multimodal Therapy Approach to Pain Management via Action on NO and NOS

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2431
Author(s):  
Natalia A. Shnayder ◽  
Marina M. Petrova ◽  
Tatiana E. Popova ◽  
Tatiana K. Davidova ◽  
Olga P. Bobrova ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Molecular Genetic ◽  
Pain Syndrome ◽  
Medical Problem ◽  
Single Nucleotide Variants ◽  
Genetic Studies ◽  
Pain Syndromes ◽  
Nos Inhibitors ◽  
Peripheral Pain

Chronic pain syndromes are an important medical problem generated by various molecular, genetic, and pathophysiologic mechanisms. Back pain, neuropathic pain, and posttraumatic pain are the most important pathological processes associated with chronic pain in adults. Standard approaches to the treatment of them do not solve the problem of pain chronicity. This is the reason for the search for new personalized strategies for the prevention and treatment of chronic pain. The nitric oxide (NO) system can play one of the key roles in the development of peripheral pain and its chronicity. The purpose of the study is to review publications devoted to changes in the NO system in patients with peripheral chronical pain syndromes. We have carried out a search for the articles published in e-Library, PubMed, Oxford Press, Clinical Case, Springer, Elsevier, and Google Scholar databases. The search was carried out using keywords and their combinations. The role of NO and NO synthases (NOS) isoforms in peripheral pain development and chronicity was demonstrated primarily from animal models to humans. The most studied is the neuronal NOS (nNOS). The role of inducible NOS (iNOS) and endothelial NOS (eNOS) is still under investigation. Associative genetic studies have shown that single nucleotide variants (SNVs) of NOS1, NOS2, and NOS3 genes encoding nNOS, iNOS, and eNOS may be associated with acute and chronic peripheral pain. Prospects for the use of NOS inhibitors to modulate the effect of drugs used to treat peripheral pain syndrome are discussed. Associative genetic studies of SNVs NOS1, NOS2, and NOS3 genes are important for understanding genetic predictors of peripheral pain chronicity and development of new personalized pharmacotherapy strategies.

101 New variant prion protein in a Japanese family with Gerstmann-Sträussler syndrome : Clinicopathological , molecular genetic studies

1996 ◽  
Vol 17 (4) ◽  
pp. S25-S26
Author(s):  
H. Furukawa ◽  
H. Tashiro ◽  
Y. Tanaka ◽  
C. Yutani ◽  
T. Yamaguchi ◽  
...  
Keyword(s):  
Prion Protein ◽  
Molecular Genetic ◽  
Japanese Family ◽  
Genetic Studies ◽  
New Variant
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