Faculty Opinions recommendation of Analysis of unilateral adrenal hyperplasia with primary aldosteronism from the aspect of messenger ribonucleic acid expression for steroidogenic enzymes: a comparative study with adrenal cortices adhering to aldosterone-producing adenoma.

2006 ◽  
Author(s):  
Michael Stowasser
Keyword(s):  
Comparative Study ◽  
Primary Aldosteronism ◽  
Ribonucleic Acid ◽  
Adrenal Hyperplasia ◽  
Steroidogenic Enzymes ◽  
Messenger Ribonucleic Acid ◽  
Unilateral Adrenal Hyperplasia ◽  
Aldosterone Producing Adenoma

scholarly journals Analysis of Unilateral Adrenal Hyperplasia with Primary Aldosteronism from the Aspect of Messenger Ribonucleic Acid Expression for Steroidogenic Enzymes: A Comparative Study with Adrenal Cortices Adhering to Aldosterone-Producing Adenoma

Endocrinology ◽  
2006 ◽  
Vol 147 (2) ◽  
pp. 999-1006 ◽  
Author(s):  
Kazuto Shigematsu ◽  
Kioko Kawai ◽  
Junji Irie ◽  
Hideki Sakai ◽  
Osamu Nakashima ◽  
...  
Keyword(s):  
Primary Aldosteronism ◽  
Zona Glomerulosa ◽  
Adrenal Hyperplasia ◽  
Steroidogenic Enzymes ◽  
Unilateral Adrenalectomy ◽  
Messenger Ribonucleic Acid ◽  
Unilateral Adrenal Hyperplasia ◽  
Aldosterone Production ◽  
Long Term Follow Up ◽  
Aldosterone Producing Adenoma

Unilateral adrenal hyperplasia with primary aldosteronism is very rare and shows similar endocrine features to aldosterone-producing adenoma and bilateral adrenal hyperplasia. In this study, the mRNA expression of steroidogenic enzymes in unilateral adrenal hyperplasia was examined by in situ hybridization. We found subcapsular micronodules composed of spironolactone body-containing cells, which showed intense expression for 3β-hydroxysteroid dehydrogenase, 11β-hydroxylase, 18-hydroxylase, and 21-hydroxylase but not 17α-hydroxylase, indicating aldosterone production. This expression pattern was the same as that in unilateral multiple adrenocortical micronodules, reported recently. Additionally, it was noted that a nodule with active aldosterone production was closely adjacent to one showing intense 17α-hydroxylase expression. In the adrenal cortices adhering to aldosterone-producing adenoma, the majority of hyperplastic zona glomerulosa and hyperplastic nodules demonstrated a decreased steroidogenic activity. However, minute nodules indicative of active aldosterone production were found at high frequency. These results suggest that the subcapsular micronodules observed might be the root of aldosterone-producing adenoma. Furthermore, we emphasize the need for long-term follow-up after unilateral adrenalectomy or enucleation of the adenoma because of the possibility that buds with autonomous aldosterone production may still be present in the contralateral or remaining adrenal tissue.

Primary Aldosteronism due to Unilateral Adrenal Hyperplasia. Report of Two Cases and Review of the Literature.

2000 ◽  
Vol 47 (4) ◽  
pp. 443-449 ◽  
Author(s):  
MASAAKI MORIOKA ◽  
TATSUYA KOBAYASHI ◽  
ATSUSHI SONE ◽  
YOJI FURUKAWA ◽  
HIROYOSHI TANAKA
Keyword(s):  
Primary Aldosteronism ◽  
Review Of The Literature ◽  
Adrenal Hyperplasia ◽  
Unilateral Adrenal Hyperplasia

scholarly journals A Case of Primary Aldosteronism Due to Unilateral Adrenal Hyperplasia

2005 ◽  
Vol 28 (4) ◽  
pp. 379-384 ◽  
Author(s):  
Yasuyuki KATAYAMA ◽  
Nobuki TAKATA ◽  
Taiji TAMURA ◽  
Akemi YAMAMOTO ◽  
Fumihiko HIRATA ◽  
...  
Keyword(s):  
Primary Aldosteronism ◽  
Adrenal Hyperplasia ◽  
Unilateral Adrenal Hyperplasia

Unilateral Adrenal Hyperplasia as a Cause of Primary Aldosteronism

1989 ◽  
Vol 82 (1) ◽  
pp. 82-86 ◽  
Author(s):  
NANCY V. DYE ◽  
NANCY J. LITTON ◽  
MADAN VARMA ◽  
WILLIAM L. ISLEY
Keyword(s):  
Primary Aldosteronism ◽  
Adrenal Hyperplasia ◽  
Unilateral Adrenal Hyperplasia

scholarly journals Angiotensin II Type 1 Receptor Autoantibodies in Primary Aldosteronism

2020 ◽  
Vol 52 (06) ◽  
pp. 379-385
Author(s):  
Lucie S. Meyer ◽  
Siyuan Gong ◽  
Martin Reincke ◽  
Tracy Ann Williams
Keyword(s):  
Angiotensin Ii ◽  
Primary Aldosteronism ◽  
Functional Role ◽  
Adrenal Hyperplasia ◽  
Endocrine Hypertension ◽  
Bilateral Adrenal Hyperplasia ◽  
Aldosterone Producing Adenoma ◽  
Agonistic Autoantibodies

AbstractPrimary aldosteronism (PA) is the most common form of endocrine hypertension. Agonistic autoantibodies against the angiotensin II type 1 receptor (AT1R-Abs) have been described in transplantation medicine and women with pre-eclampsia and more recently in patients with PA. Any functional role of AT1R-Abs in either of the two main subtypes of PA (aldosterone-producing adenoma or bilateral adrenal hyperplasia) requires clarification. In this review, we discuss the studies performed to date on AT1R-Abs in PA.

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