Faculty Opinions recommendation of Dissecting the molecular control of endothelial NO synthase by caveolin-1 using cell-permeable peptides.

2005 ◽  
Author(s):  
David Bates
Keyword(s):  
No Synthase ◽  
Molecular Control ◽  
Caveolin 1 ◽  
Endothelial No Synthase

scholarly journals Dissecting the molecular control of endothelial NO synthase by caveolin-1 using cell-permeable peptides

2005 ◽  
Vol 102 (3) ◽  
pp. 761-766 ◽  
Author(s):  
P. N. Bernatchez ◽  
P. M. Bauer ◽  
J. Yu ◽  
J. S. Prendergast ◽  
P. He ◽  
...  
Keyword(s):  
No Synthase ◽  
Molecular Control ◽  
Caveolin 1 ◽  
Endothelial No Synthase

scholarly journals Apolipoprotein E Enhances Endothelial-NO Production by Modulating Caveolin 1 Interaction With Endothelial NO Synthase

Hypertension ◽  
2012 ◽  
Vol 60 (4) ◽  
pp. 1040-1046 ◽  
Author(s):  
Lili Yue ◽  
Jing-Tan Bian ◽  
Ivana Grizelj ◽  
Ana Cavka ◽  
Shane A. Phillips ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
No Synthase ◽  
No Production ◽  
Caveolin 1 ◽  
Endothelial No Synthase

scholarly journals Role of Gi/o-Src kinase-PI3K/Akt pathway and caveolin-1 in β2-adrenoceptor coupling to endothelial NO synthase in mouse pulmonary artery

2011 ◽  
Vol 23 (7) ◽  
pp. 1136-1143 ◽  
Author(s):  
Sébastien Banquet ◽  
Estelle Delannoy ◽  
Abdelali Agouni ◽  
Chantal Dessy ◽  
Sabrina Lacomme ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Src Kinase ◽  
No Synthase ◽  
Akt Pathway ◽  
Caveolin 1 ◽  
Endothelial No Synthase

Growth differentiation factor 15 impairs aortic contractile and relaxing function through altered caveolar signaling of the endothelium

2013 ◽  
Vol 304 (5) ◽  
pp. H709-H718 ◽  
Author(s):  
Magdalena Mazagova ◽  
Hendrik Buikema ◽  
Sjoerd W. Landheer ◽  
Peter Vavrinec ◽  
Azuwerus van Buiten ◽  
...  
Keyword(s):  
Vascular Function ◽  
Independent Predictor ◽  
No Synthase ◽  
Wild Type ◽  
Growth Differentiation Factor 15 ◽  
Caveolin 1 ◽  
Endothelial No Synthase ◽  
Differentiation Factor ◽  
Contraction And Relaxation ◽  
Dependent Mechanism

Growth differentiation factor 15 (GDF15) is an independent predictor of cardiovascular disease, and increased GDF15 levels have been associated with endothelial dysfunction in selected patients. We therefore investigated whether GDF15 modulates endothelial function in aortas of wild-type (WT) and GDF15 knockout (KO) mice. Vascular contractions to phenylephrine and relaxation to ACh were assessed in aortas obtained from healthy WT and GDF15 KO mice. The effects of GDF15 pretreatment and the involvement of ROS or caveolae were determined. Phenylephrine-induced contractions and ACh-mediated relaxations were similar in WT and GDF15 KO mice. Pretreatment with GDF15 inhibited contraction and relaxation in both groups. Inhibition of contraction by GDF15 was absent in denuded vessels or after blockade of nitric oxide (NO) synthase. Relaxation in WT mice was mediated mainly through NO and an unidentified endothelium-derived hyperpolarizin factor (EDHF), whereas GDF15 KO mice mainly used prostaglandins and EDHF. Pretreatment with GDF15 impaired relaxation in WT mice by decreasing NO; in GDF15 KO mice, this was mediated by decreased action of prostaglandins. Disruption of caveolae resulted in a similar inhibition of vascular responses as GDF15. ROS inhibition did not affect vascular function. In cultured endothelial cells, GDF15 pretreatment caused a dissociation between caveolin-1 and endothelial NO synthase. In conclusion, GDF15 impairs aortic contractile and relaxing function through an endothelium-dependent mechanism involving altered caveolar endothelial NO synthase signaling.

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