Faculty Opinions recommendation of Regeneration of sensory axons within the injured spinal cord induced by intraganglionic cAMP elevation.

2002 ◽  
Author(s):  
William D Snider
Keyword(s):  
Spinal Cord ◽  
Injured Spinal Cord ◽  
Sensory Axons ◽  
Camp Elevation

scholarly journals Regeneration of Sensory Axons within the Injured Spinal Cord Induced by Intraganglionic cAMP Elevation

Neuron ◽  
2002 ◽  
Vol 34 (6) ◽  
pp. 885-893 ◽  
Author(s):  
Simona Neumann ◽  
Frank Bradke ◽  
Marc Tessier-Lavigne ◽  
Allan I. Basbaum
Keyword(s):  
Spinal Cord ◽  
Injured Spinal Cord ◽  
Sensory Axons ◽  
Camp Elevation

Activated Macrophage/Microglial Cells Can Promote the Regeneration of Sensory Axons into the Injured Spinal Cord

1997 ◽  
Vol 148 (2) ◽  
pp. 433-443 ◽  
Author(s):  
Chantal M.F. Prewitt ◽  
Ingrid R. Niesman ◽  
Cynthia J.M. Kane ◽  
John D. Houlé
Keyword(s):  
Spinal Cord ◽  
Microglial Cells ◽  
Injured Spinal Cord ◽  
Sensory Axons ◽  
Activated Macrophage

scholarly journals Intravital Assessment of Cells Responses to Conducting Polymer-Coated Carbon Microfibres for Bridging Spinal Cord Injury

Cells ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 73
Author(s):  
Bilal El Waly ◽  
Vincent Escarrat ◽  
Jimena Perez-Sanchez ◽  
Jaspreet Kaur ◽  
Florence Pelletier ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Immune Cell ◽  
Two Photon ◽  
Sensory Axons ◽  
Promising Therapeutic Approach ◽  
Cord Injury ◽  
Biochemical Signals ◽  
Coated Carbon ◽  
Striking Effect

The extension of the lesion following spinal cord injury (SCI) poses a major challenge for regenerating axons, which must grow across several centimetres of damaged tissue in the absence of ordered guidance cues. Biofunctionalized electroconducting microfibres (MFs) that provide biochemical signals, as well as electrical and mechanical cues, offer a promising therapeutic approach to help axons overcome this blind journey. We used poly(3,4-ethylenedioxythiophene)-coated carbon MFs functionalized with cell adhesion molecules and growth factors to bridge the spinal cord after a partial unilateral dorsal quadrant lesion (PUDQL) in mice and followed cellular responses by intravital two-photon (2P) imaging through a spinal glass window. Thy1-CFP//LysM-EGFP//CD11c-EYFP triple transgenic reporter animals allowed real time simultaneous monitoring of axons, myeloid cells and microglial cells in the vicinity of the implanted MFs. MF biocompatibility was confirmed by the absence of inflammatory storm after implantation. We found that the sprouting of sensory axons was significantly accelerated by the implantation of functionalized MFs after PUDQL. Their implantation produced better axon alignment compared to random and misrouted axon regeneration that occurred in the absence of MF, with a most striking effect occurring two months after injury. Importantly, we observed differences in the intensity and composition of the innate immune response in comparison to PUDQL-only animals. A significant decrease of immune cell density was found in MF-implanted mice one month after lesion along with a higher ratio of monocyte-derived dendritic cells whose differentiation was accelerated. Therefore, functionalized carbon MFs promote the beneficial immune responses required for neural tissue repair, providing an encouraging strategy for SCI management.

scholarly journals Transplantation Strategies to Reconstruct the Injured Spinal Cord and its Peripheral Motor Connections in the Adult Rat

1992 ◽  
Vol 3 (4) ◽  
pp. 261-262 ◽  
Author(s):  
Jean-Claude Horvat ◽  
Monique Pecot-Dechavassine ◽  
Claude Baillet-Derbin ◽  
Jean-Claude Mira ◽  
Jian Hui Ye ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Injured Spinal Cord ◽  
Adult Rat ◽  
Peripheral Motor

Stem cells in the injured spinal cord: reducing the pain and increasing the gain

2005 ◽  
Vol 8 (3) ◽  
pp. 259-260 ◽  
Author(s):  
Sandra Klein ◽  
Clive N Svendsen
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Injured Spinal Cord

scholarly journals Expression of endoplasmic reticulum chaperone ERP29 in the injured spinal cord

2003 ◽  
Vol 7 (3) ◽  
pp. 265-269 ◽  
Author(s):  
Soojung Park ◽  
Ho‐Myung Hwang ◽  
Young‐Ho Lee ◽  
Kwan‐Hee You ◽  
Kee‐Sun Shin ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Endoplasmic Reticulum ◽  
Injured Spinal Cord ◽  
Endoplasmic Reticulum Chaperone

scholarly journals TLR4 Deficiency Impairs Oligodendrocyte Formation in the Injured Spinal Cord

2016 ◽  
Vol 36 (23) ◽  
pp. 6352-6364 ◽  
Author(s):  
Jamie S. Church ◽  
Kristina A. Kigerl ◽  
Jessica K. Lerch ◽  
Phillip G. Popovich ◽  
Dana M. McTigue
Keyword(s):  
Spinal Cord ◽  
Injured Spinal Cord
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