scholarly journals Transplantation Strategies to Reconstruct the Injured Spinal Cord and its Peripheral Motor Connections in the Adult Rat

1992 ◽  
Vol 3 (4) ◽  
pp. 261-262 ◽  
Author(s):  
Jean-Claude Horvat ◽  
Monique Pecot-Dechavassine ◽  
Claude Baillet-Derbin ◽  
Jean-Claude Mira ◽  
Jian Hui Ye ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Injured Spinal Cord ◽  
Adult Rat ◽  
Peripheral Motor

Adenoviral gene transfer to the injured spinal cord of the adult rat

2000 ◽  
Vol 12 (9) ◽  
pp. 3437-3442 ◽  
Author(s):  
Andrea B. Huber ◽  
Markus U. Ehrengruber ◽  
Martin E. Schwab ◽  
Christian Brösamle
Keyword(s):  
Spinal Cord ◽  
Gene Transfer ◽  
Injured Spinal Cord ◽  
Adenoviral Gene Transfer ◽  
Adult Rat

scholarly journals An experimental model for the transplantation of fetal central nervous system cells to the injured spinal cord in rats

2002 ◽  
Vol 57 (6) ◽  
pp. 257-264 ◽  
Author(s):  
Tarcísio Eloy Pessoa de Barros Filho ◽  
Reginaldo Perilo de Oliveira ◽  
Ana Maria Tsanaclis ◽  
Erika Meirelles Kalil Pessoa de Barros ◽  
Alexandre Fogaça Cristante ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Experimental Model ◽  
Fetal Tissue ◽  
Spinal Cord Tissue ◽  
Injured Spinal Cord ◽  
Functional Changes ◽  
Adult Rat ◽  
Cord Injury

INTRODUCTION: Traumatic spinal cord injury is one of the most disabling conditions occurring in man and thus stimulates a strong interest in its histopathological, biochemical, and functional changes, primarily as we search for preventive and therapeutic methods. PURPOSE: To develop an experimental model for transplantation of cells from the fetal rat central nervous system to the site of an injured spinal cord of an adult rat in which the transplanted cells survive and become integrated. This experimental model will facilitate investigations of factors that promote regeneration and functional recovery after spinal cord trauma. MATERIAL AND METHODS: Fifteen adult Wistar rats underwent laminectomy, and an spinal cord lesion was made with microdissection. Fetal spinal cord tissue was then transplanted to the site of the injury. The rats were monitored over a 48-hour period, and then their vertebral column was completely removed for histological analysis. RESULTS: In 60% of transplanted rats, the fetal tissue at the injured site remained viable in the site of the lesion.

Comparison of the Growth and Fate of Fetal Spinal Iso- and Allografts in the Adult Rat Injured Spinal Cord

1996 ◽  
Vol 142 (1) ◽  
pp. 128-143 ◽  
Author(s):  
Daniel P. Theele ◽  
Gregory W. Schrimsher ◽  
Paul J. Reier
Keyword(s):  
Spinal Cord ◽  
Injured Spinal Cord ◽  
Adult Rat

Syngeneic grafting of adult rat DRG-derived schwann cells to the injured spinal cord

1993 ◽  
Vol 30 (3-4) ◽  
pp. 507-514 ◽  
Author(s):  
D. Martin ◽  
J. Schoenen ◽  
P. Delree ◽  
J.-M. Rigo ◽  
B. Rogister ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Schwann Cells ◽  
Injured Spinal Cord ◽  
Adult Rat
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