Faculty Opinions recommendation of Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development.

2003 ◽  
Author(s):  
Kristin White
Keyword(s):  
Notch Signaling ◽  
Egf Receptor ◽  
Phospholipid Membrane ◽  
Membrane Composition ◽  
Drosophila Development

scholarly journals Notch signaling coordinates ommatidial rotation in the Drosophila eye via transcriptional regulation of the EGF-Receptor ligand Argos

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yildiz Koca ◽  
Benjamin E. Housden ◽  
William J. Gault ◽  
Sarah J. Bray ◽  
Marek Mlodzik
Keyword(s):  
Notch Signaling ◽  
Cell Fate ◽  
Planar Cell Polarity ◽  
Egf Receptor ◽  
Control Cell ◽  
Loss Of Function ◽  
Egfr Signaling ◽  
Specific Expression ◽  
Egfr Signaling Pathway ◽  
Ommatidial Rotation

AbstractIn all metazoans, a small number of evolutionarily conserved signaling pathways are reiteratively used during development to orchestrate critical patterning and morphogenetic processes. Among these, Notch (N) signaling is essential for most aspects of tissue patterning where it mediates the communication between adjacent cells to control cell fate specification. In Drosophila, Notch signaling is required for several features of eye development, including the R3/R4 cell fate choice and R7 specification. Here we show that hypomorphic alleles of Notch, belonging to the Nfacet class, reveal a novel phenotype: while photoreceptor specification in the mutant ommatidia is largely normal, defects are observed in ommatidial rotation (OR), a planar cell polarity (PCP)-mediated cell motility process. We demonstrate that during OR Notch signaling is specifically required in the R4 photoreceptor to upregulate the transcription of argos (aos), an inhibitory ligand to the epidermal growth factor receptor (EGFR), to fine-tune the activity of EGFR signaling. Consistently, the loss-of-function defects of Nfacet alleles and EGFR-signaling pathway mutants are largely indistinguishable. A Notch-regulated aos enhancer confers R4 specific expression arguing that aos is directly regulated by Notch signaling in this context via Su(H)-Mam-dependent transcription.

Effects ofdamand/orseqAMutations on the Fatty Acid and Phospholipid Membrane Composition ofSalmonella entericaSerovar Typhimurium

2010 ◽  
Vol 7 (5) ◽  
pp. 573-583 ◽  
Author(s):  
Amine Aloui ◽  
Mouadh Mihoub ◽  
Mohamed Marwan Sethom ◽  
Abdelwaheb Chatti ◽  
Moncef Feki ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Phospholipid Membrane ◽  
Membrane Composition

scholarly journals Current Applications and Discoveries Related to the Membrane Components of Circulating Tumor Cells and Extracellular Vesicles

Cells ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 2221
Author(s):  
Luis Enrique Cortés-Hernández ◽  
Zahra Eslami-S ◽  
Bruno Costa-Silva ◽  
Catherine Alix-Panabières
Keyword(s):  
Nucleic Acids ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Extracellular Vesicles ◽  
Cancer Progression ◽  
Liquid Biopsy ◽  
Clinical Information ◽  
Phospholipid Membrane ◽  
Membrane Composition ◽  
Metastatic Cascade

In cancer, many analytes can be investigated through liquid biopsy. They play fundamental roles in the biological mechanisms underpinning the metastatic cascade and provide clinical information that can be monitored in real time during the natural course of cancer. Some of these analytes (circulating tumor cells and extracellular vesicles) share a key feature: the presence of a phospholipid membrane that includes proteins, lipids and possibly nucleic acids. Most cell-to-cell and cell-to-matrix interactions are modulated by the cell membrane composition. To understand cancer progression, it is essential to describe how proteins, lipids and nucleic acids in the membrane influence these interactions in cancer cells. Therefore, assessing such interactions and the phospholipid membrane composition in different liquid biopsy analytes might be important for future diagnostic and therapeutic strategies. In this review, we briefly describe some of the most important surface components of circulating tumor cells and extracellular vesicles as well as their interactions, putting an emphasis on how they are involved in the different steps of the metastatic cascade and how they can be exploited by the different liquid biopsy technologies.

The EGF receptor and notch signaling pathways control the initiation of the morphogenetic furrow duringDrosophilaeye development

Development ◽  
2001 ◽  
Vol 128 (14) ◽  
pp. 2689-2697 ◽  
Author(s):  
Justin P. Kumar ◽  
Kevin Moses
Keyword(s):  
Pattern Formation ◽  
Notch Signaling ◽  
Imaginal Disc ◽  
Egf Receptor ◽  
Retinal Development ◽  
Growth Factor Receptor ◽  
Leading Edge ◽  
Morphogenetic Furrow ◽  
Epidermal Growth ◽  
Eye Imaginal Disc

The onset of pattern formation in the developing Drosophila retina begins with the initiation of the morphogenetic furrow, the leading edge of a wave of retinal development that transforms a uniform epithelium, the eye imaginal disc into a near crystalline array of ommatidial elements. The initiation of this wave of morphogenesis is under the control of the secreted morphogens Hedgehog (Hh), Decapentaplegic (Dpp) and Wingless (Wg). We show that the Epidermal Growth Factor Receptor and Notch signaling cascades are crucial components that are also required to initiate retinal development. We also show that the initiation of the morphogenetic furrow is the sum of two genetically separable processes: (1) the ‘birth’ of pattern formation at the posterior margin of the eye imaginal disc; and (2) the subsequent ‘reincarnation’ of retinal development across the epithelium.

scholarly journals EGF Receptor and Notch Signaling Act Upstream of Eyeless/Pax6 to Control Eye Specification

Cell ◽  
2001 ◽  
Vol 104 (5) ◽  
pp. 687-697 ◽  
Author(s):  
Justin P. Kumar ◽  
Kevin Moses
Keyword(s):  
Notch Signaling ◽  
Egf Receptor

scholarly journals CAF-1 promotes Notch signaling through epigenetic control of target gene expression during Drosophila development

Development ◽  
2013 ◽  
Vol 140 (17) ◽  
pp. 3635-3644 ◽  
Author(s):  
Z. Yu ◽  
H. Wu ◽  
H. Chen ◽  
R. Wang ◽  
X. Liang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Notch Signaling ◽  
Target Gene ◽  
Drosophila Development ◽  
Target Gene Expression ◽  
Epigenetic Control
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