scholarly journals Current Applications and Discoveries Related to the Membrane Components of Circulating Tumor Cells and Extracellular Vesicles

Cells ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 2221
Author(s):  
Luis Enrique Cortés-Hernández ◽  
Zahra Eslami-S ◽  
Bruno Costa-Silva ◽  
Catherine Alix-Panabières
Keyword(s):  
Nucleic Acids ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Extracellular Vesicles ◽  
Cancer Progression ◽  
Liquid Biopsy ◽  
Clinical Information ◽  
Phospholipid Membrane ◽  
Membrane Composition ◽  
Metastatic Cascade

In cancer, many analytes can be investigated through liquid biopsy. They play fundamental roles in the biological mechanisms underpinning the metastatic cascade and provide clinical information that can be monitored in real time during the natural course of cancer. Some of these analytes (circulating tumor cells and extracellular vesicles) share a key feature: the presence of a phospholipid membrane that includes proteins, lipids and possibly nucleic acids. Most cell-to-cell and cell-to-matrix interactions are modulated by the cell membrane composition. To understand cancer progression, it is essential to describe how proteins, lipids and nucleic acids in the membrane influence these interactions in cancer cells. Therefore, assessing such interactions and the phospholipid membrane composition in different liquid biopsy analytes might be important for future diagnostic and therapeutic strategies. In this review, we briefly describe some of the most important surface components of circulating tumor cells and extracellular vesicles as well as their interactions, putting an emphasis on how they are involved in the different steps of the metastatic cascade and how they can be exploited by the different liquid biopsy technologies.

scholarly journals Do malignant cells sleep at night?

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Luis Enrique Cortés-Hernández ◽  
Zahra Eslami-S ◽  
Antoine M. Dujon ◽  
Mathieu Giraudeau ◽  
Beata Ujvari ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Cancer Progression ◽  
Liquid Biopsy ◽  
Biological Rhythms ◽  
Clinical Implications ◽  
Malignant Cells ◽  
Metastatic Cascade ◽  
Key Players

AbstractBiological rhythms regulate the biology of most, if not all living creatures, from whole organisms to their constitutive cells, their microbiota, and also parasites. Here, we present the hypothesis that internal and external ecological variations induced by biological cycles also influence or are exploited by cancer cells, especially by circulating tumor cells, the key players in the metastatic cascade. We then discuss the possible clinical implications of the effect of biological cycles on cancer progression, and how they could be exploited to improve and standardize methods used in the liquid biopsy field.

scholarly journals Liquid biopsy in patients with hepatocellular carcinoma: Circulating tumor cells and cell-free nucleic acids

2017 ◽  
Vol 23 (31) ◽  
pp. 5650 ◽  
Author(s):  
Wataru Okajima ◽  
Shuhei Komatsu ◽  
Daisuke Ichikawa ◽  
Mahito Miyamae ◽  
Takuma Ohashi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Nucleic Acids ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Liquid Biopsy

scholarly journals Liquid biopsy in patients with pancreatic cancer: Circulating tumor cells and cell-free nucleic acids

2016 ◽  
Vol 22 (25) ◽  
pp. 5627 ◽  
Author(s):  
Taisuke Imamura ◽  
Shuhei Komatsu ◽  
Daisuke Ichikawa ◽  
Tsutomu Kawaguchi ◽  
Mahito Miyamae ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Nucleic Acids ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Liquid Biopsy

scholarly journals Opportunities and Challenges of Liquid Biopsy in Thyroid Cancer

2021 ◽  
Vol 22 (14) ◽  
pp. 7707
Author(s):  
Chiara Romano ◽  
Federica Martorana ◽  
Maria Stella Pennisi ◽  
Stefania Stella ◽  
Michele Massimino ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Nucleic Acids ◽  
Tumor Cells ◽  
Extracellular Vesicles ◽  
Liquid Biopsy ◽  
Endocrine System ◽  
Invasive Approach ◽  
Medical Needs ◽  
Non Invasive ◽  
Thyroid Malignancies

Thyroid cancer is the most common malignancy of the endocrine system, encompassing different entities with distinct histological features and clinical behavior. The diagnostic definition, therapeutic approach, and follow-up of thyroid cancers display some controversial aspects that represent unmet medical needs. Liquid biopsy is a non-invasive approach that detects and analyzes biological samples released from the tumor into the bloodstream. With the use of different technologies, tumor cells, free nucleic acids, and extracellular vesicles can be retrieved in the serum of cancer patients and valuable molecular information can be obtained. Recently, a growing body of evidence is accumulating concerning the use of liquid biopsy in thyroid cancer, as it can be exploited to define a patient’s diagnosis, estimate their prognosis, and monitor tumor recurrence or treatment response. Indeed, liquid biopsy can be a valuable tool to overcome the limits of conventional management of thyroid malignancies. In this review, we summarize currently available data about liquid biopsy in differentiated, poorly differentiated/anaplastic, and medullary thyroid cancer, focusing on circulating tumor cells, circulating free nucleic acids, and extracellular vesicles.

scholarly journals Molecular and Functional Characterization of Circulating Tumor Cells: From Discovery to Clinical Application

2019 ◽  
Vol 66 (1) ◽  
pp. 97-104 ◽  
Author(s):  
Luis Enrique Cortés-Hernández ◽  
Zahra Eslami-S ◽  
Klaus Pantel ◽  
Catherine Alix-Panabières
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Liquid Biopsy ◽  
Functional Characterization ◽  
Clinical Information ◽  
In Vivo Models ◽  
Functional Studies

Abstract BACKGROUND One of the objectives for the liquid biopsy is to become a surrogate to tissue biopsies in diagnosis of cancer as a minimally invasive method, with clinical utility in real-time follow-ups of patients. To achieve this goal, it is still necessary to achieve a better understanding of the mechanisms of cancer and the biological principles that govern its behavior, particularly with regard to circulating tumor cells (CTCs). CONTENT The isolation, enumeration, detection, and characterization of CTCs have already proven to provide relevant clinical information about patient prognosis and treatment prediction. Moreover, CTCs can be analyzed at the genome, proteome, transcriptome, and secretome levels and can also be used for functional studies in in vitro and in vivo models. These features, taken together, have made CTCs a very valuable biosource. SUMMARY To further advance the field and discover new clinical applications for CTCs, several studies have been performed to learn more about these cells and better understand the biology of metastasis. In this review, we describe the recent literature on the topic of liquid biopsy with particular focus on the biology of CTCs.

Emerging Nanotechnologies for Liquid Biopsy: The Detection of Circulating Tumor Cells and Extracellular Vesicles

2018 ◽  
Vol 31 (45) ◽  
pp. 1805344 ◽  
Author(s):  
Wenzhe Li ◽  
Huayi Wang ◽  
Zijian Zhao ◽  
Houqian Gao ◽  
Changliang Liu ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Extracellular Vesicles ◽  
Liquid Biopsy

scholarly journals Nanotechnologies: Emerging Nanotechnologies for Liquid Biopsy: The Detection of Circulating Tumor Cells and Extracellular Vesicles (Adv. Mater. 45/2019)

2019 ◽  
Vol 31 (45) ◽  
pp. 1970318 ◽  
Author(s):  
Wenzhe Li ◽  
Huayi Wang ◽  
Zijian Zhao ◽  
Houqian Gao ◽  
Changliang Liu ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Extracellular Vesicles ◽  
Liquid Biopsy
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