Faculty Opinions recommendation of Visualization of lymphotoxin-beta and lymphotoxin-beta receptor expression in mouse embryos.

2002 ◽  
Author(s):  
David Chaplin
Keyword(s):  
Mouse Embryos ◽  
Receptor Expression ◽  
Beta Receptor ◽  
Lymphotoxin Beta Receptor

scholarly journals Metabolic activation and colitis pathogenesis is prevented by lymphotoxin β receptor expression in neutrophils

2021 ◽  
Author(s):  
Thomas Riffelmacher ◽  
Daniel A. Giles ◽  
Sonja Zahner ◽  
Martina Dicker ◽  
Alexander Y. Andreyev ◽  
...  
Keyword(s):  
Severe Disease ◽  
Metabolic Activation ◽  
Cell Types ◽  
Receptor Expression ◽  
Neutrophil Accumulation ◽  
Functional Studies ◽  
Mitochondrial Ros ◽  
Tnf Superfamily ◽  
Β Receptor ◽  
Lymphotoxin Beta Receptor

AbstractInflammatory bowel disease is characterized by an exacerbated intestinal immune response, but the critical mechanisms regulating immune activation remain incompletely understood. We previously reported that the TNF-superfamily molecule TNFSF14 (LIGHT) is required for preventing severe disease in mouse models of colitis. In addition, deletion of lymphotoxin beta receptor (LTβR), which binds LIGHT, also led to aggravated colitis pathogenesis. Here, we aimed to determine the cell type(s) requiring LTβR and the mechanism critical for exacerbation of colitis. Specific deletion of LTβR in neutrophils (LTβRΔN), but not in several other cell types, was sufficient to induce aggravated colitis and colonic neutrophil accumulation. Mechanistically, RNA-Seq analysis revealed LIGHT-induced suppression of cellular metabolism, and mitochondrial function, that was dependent on LTβR. Functional studies confirmed increased mitochondrial mass and activity, associated with excessive mitochondrial ROS production and elevated glycolysis at steady-state and during colitis. Targeting these metabolic changes rescued exacerbated disease severity. Our results demonstrate that LIGHT signals to LTβR on neutrophils to suppress metabolic activation and thereby prevents exacerbated immune pathogenesis during colitis.

scholarly journals Control of TGF-beta receptor expression in bone

10.2741/a268 ◽  
1998 ◽  
Vol 3 (4) ◽  
pp. d113-124 ◽  
Author(s):  
Michael Centrella
Keyword(s):  
Receptor Expression ◽  
Tgf Beta ◽  
Beta Receptor

Lymphotoxin-beta receptor activation on macrophages ameliorates acute DSS-induced intestinal inflammation in a TRIM30α-dependent manner

2012 ◽  
Vol 51 (2) ◽  
pp. 128-135 ◽  
Author(s):  
Nadin Wimmer ◽  
Barbara Huber ◽  
Anja K. Wege ◽  
Nicola Barabas ◽  
Johann Röhrl ◽  
...  
Keyword(s):  
Intestinal Inflammation ◽  
Receptor Activation ◽  
Dependent Manner ◽  
Beta Receptor ◽  
Lymphotoxin Beta Receptor
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