Lymphotoxin-beta receptor expression and its related signaling pathways govern dendritic cell homeostasis and function

Immunobiology ◽  
2012 ◽  
Vol 217 (12) ◽  
pp. 1250-1258 ◽  
Author(s):  
Carl De Trez
Keyword(s):  
Dendritic Cell ◽  
Signaling Pathways ◽  
Receptor Expression ◽  
Cell Homeostasis ◽  
Beta Receptor ◽  
And Function ◽  
Lymphotoxin Beta Receptor

scholarly journals Toll-like receptor expression and function in human dendritic cell subsets: implications for dendritic cell-based anti-cancer immunotherapy

2010 ◽  
Vol 59 (10) ◽  
pp. 1573-1582 ◽  
Author(s):  
Gerty Schreibelt ◽  
Jurjen Tel ◽  
Kwinten H. E. W. J. Sliepen ◽  
Daniel Benitez-Ribas ◽  
Carl G. Figdor ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Cancer Immunotherapy ◽  
Receptor Expression ◽  
Human Dendritic Cell ◽  
Toll Like Receptor ◽  
Anti Cancer ◽  
Dendritic Cell Subsets ◽  
And Function

scholarly journals Measles virus modulates chemokine release and chemotactic responses of dendritic cells

2009 ◽  
Vol 90 (4) ◽  
pp. 909-914 ◽  
Author(s):  
Marion Abt ◽  
Evelyn Gassert ◽  
Sibylle Schneider-Schaulies
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Dendritic Cell ◽  
Chemokine Receptor ◽  
Measles Virus ◽  
Receptor Expression ◽  
Cell Recruitment ◽  
Receptor Modulation ◽  
And Function ◽  
Dc Maturation

Interference with dendritic cell (DC) maturation and function is considered to be central to measles virus (MV)-induced immunosuppression. Temporally ordered production of chemokines and switches in chemokine receptor expression are essential for pathogen-driven DC maturation as they are prerequisites for chemotaxis and T cell recruitment. We found that MV infection of immature monocyte-derived DCs induced transcripts specific for CCL-1, -2, -3, -5, -17 and -22, CXCL-10 and CXCL-11, yet did not induce CXCL-8 (interleukin-8) and CCL-20 at the mRNA and protein level. Within 24 h post-infection, T cell attraction was not detectably impaired by these cells. MV infection failed to promote the switch from CCR5 to CCR7 expression and this correlated with chemotactic responses of MV-matured DC cultures to CCL-3 rather than to CCL-19. Moreover, the chemotaxis of MV-infected DCs to either chemokine was compromised, indicating that MV also interferes with this property independently of chemokine receptor modulation.

scholarly journals LYMPHOTOXIN BETA RECEPTOR REGULATES TREG STABILITY, MIGRATION, AND FUNCTION

2020 ◽  
Vol 104 (S3) ◽  
pp. S198-S198
Author(s):  
Vikas Saxena ◽  
Wenji Piao ◽  
Lushen Li ◽  
Yanbao Xiong ◽  
Christina Paluskievicz ◽  
...  
Keyword(s):  
Beta Receptor ◽  
And Function ◽  
Lymphotoxin Beta Receptor

Tsc1-dependent transcriptional programming of dendritic cell homeostasis and function

2018 ◽  
Vol 363 (1) ◽  
pp. 73-83
Author(s):  
Yuechen Luo ◽  
Jingru Liu ◽  
Xiaolei Sun ◽  
Tiantian Feng ◽  
Lijun Fang ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Cell Homeostasis ◽  
And Function
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