APPLICATION OF 2D ULTRASOUND, ELASTOGRAPHY ARFI AND MAMMOGRAPHY FOR DIAGNOSIS OF SOLID TUMORS IN BREAST

2019 ◽  
pp. 58-65
Author(s):  
Thi Song Huong Tran ◽  
Hoang Minh Thi Nguyen
Keyword(s):  
Solid Tumors ◽  
Malignant Tumors ◽  
Breast Tumors ◽  
Ultrasound Elastography ◽  
Average Score ◽  
Benign Tumors ◽  
Cut Points ◽  
Imaging Results ◽  
2D Ultrasound ◽  
Parallel Axis

Objective: To study image characteristics and values of 2D ultrasound, elastography ARFI and Mammography in the diagnosis of solid tumors in the breast. Methods: 34 patients with breast tumors were examined for 2D ultrasound, elastography ARFI and Mammography imaging. Results of 2D ultrasound, elastography ARFI and mammography were classified according to BI-RADS ACR 2013. Comparison of image results with pathology to determine the diagnostic value of 2D ultrasound, 2D ultrasound combines with ARFI, and combine with Mammography. Results: 34 patients in which 14 benign tumors and 20 malignant tumors. On ultrasound 2D: Benign tumors have the main characteristics are oval, well - defined, parallel axis with skin, hypoechogen. Malignant tumors have the main features of spiculation, non-parallel axis with the skin, markedly hypoechoic with posterior acoustic shadowing, microcalcification, vascular proliferation and invasion. On ARFI, an average score of Ako Itoh of benign tumors and malignant tumors is 2.86 ± 0.36 and cut points between E3 and E4; SWVi, SWVb in benign tumors are smaller than malignant tumors with the cut points are: 7.13 m/s; 3.13m/s. 2D + ARFI: 100% Se, Sp 92.86%, PPV 95.24%, 100% higher than 2D ultrasound and 2D + ARFI combined mammography have the same value. Conclusion: 2D ultrasound combines with ARFI and mammography is valuable in diagnosis and differential diagnosis of breast tumors. Key words: 2D ultrasound, Elastography ARFI, Mammography

APPLICATION OF ELASTOGRAPHY FOR DIAGNOSIS BREAST TUMORS

2018 ◽  
Vol 8 (6) ◽  
pp. 8-14
Author(s):  
Huong Tran Thi Song ◽  
Yen Vo Thi Kim ◽  
Quan Nguyen Phuoc Bao
Keyword(s):  
Breast Cancer ◽  
Malignant Tumors ◽  
Normal Breast ◽  
Benign Tumors ◽  
Breast Lesions ◽  
Soft Or ◽  
The Past ◽  
2D Ultrasound ◽  
Malignant Lesions ◽  
A New Technique

Breast tumor is common in women. Benign tumors account for 80%, malignant tumors account for 20%. Breast cancer is the most common and deadly cancer among women, including Vietnam. Elastography, evaluates the stiffness of the tissue, helps to distinguish soft or hard tumors, which can help distinguish benign or malignant. Benign lesions tend to be softer than malignant lesions. There are two types of elastography: SE (Strain Elastography) and Shear Ware Elastography (SWE). In examining breast lesions, the maligne tumor tends to be stronger and the higher the velocity. Studies have shown that the SWE features should be combined with 2D ultrasound to complement the BIRADS classification. Elastography is a new technique that has emerged in the past few years, promising good diagnostic prospects, more and more research and application of elastography in diagnostics breast lesions. Breast elastogarphy, survey of hardness of breast cancer showed 4 times higher than that of benign tumor and 7 folds of normal breast tissue.

ARFI ELASTOGRAPHY IN THE DIAGNOSIS OF FOCAL BREAST LESIONS

2017 ◽  
pp. 23-29
Author(s):  
Thi Kim Yen Vo ◽  
Phuoc Bao Quan Nguyen ◽  
Thanh Thao Nguyen
Keyword(s):  
Malignant Tumors ◽  
Acoustic Radiation ◽  
Radiation Force ◽  
Acoustic Radiation Force ◽  
Acoustic Radiation Force Impulse ◽  
Benign Tumors ◽  
Breast Lesions ◽  
Focal Lesions ◽  
Arfi Elastography ◽  
2D Ultrasound

Objective: To describe the sonographic characteristics of the focal breasst lesions using Acoustic Radiation Force Impulse Imaging (ARFI), and to evaluate the role of ARFI technique in combination with 2D Ultrasound in diagnosing focal breast lesions. Methods: 2D Ultrasound and ARFI Elastography were caried out in 52 patients who have focal lesions of breast. Images of 2D Ultrasound were classified according to ACR 2013. ARFI Elastography was performed by 2 techniques: “Virtual Touch HD tissue imaging” in order to image of strain distribution and “Virtual Touch HD Tissue quantification imaging” to measure the shear wave velocity (SWV) in the tissue. Strain distribution was classified according to Ako Itoh scale. SWV were measured in 4 positions: internal the lesion (SWVi), boundary zone (SWVb), glandular tissue and fatty tissue next to lesion (SWg and SWf). According to the results of pathology, we determine and compare the value between 2D Ultrasound plus ARFI elastography and 2D Ultrasound alone. Results: 52 patients with breast focal lesions: 22 malignant tumors and 30 benign tumors. Mean Ako Itoh scale of benign tumors were 2.19 ± 1.13 and malignant tumors were 4.72 ± 0.55; the cut-off value was between E3 và E4. SWVi, SWVb, SWVf, SWVg of benign tumors were lower than malignant tumors with cut-off values were 3.32 m/s; 6.01m/s; 1.08m/s; 2.37m/s, respectively. 2D Ultrasound plus ARFI Elastography: Se 100%, Sp 90%, PPV 88%, NPV 100%, Acc 94.2% (p<0.001, K = 0.884). Conclutions: In addition to the morphologic characteristics of breast lesions, ARFI provides information about lesion’s tissue elasticity, which can be a useful tool to differentitate malignant lesions from benign ones. Key words: elastography, focal breast lesions, Acoustic Radiation Force Impulse Imaging

scholarly journals Study on the Effect of MRI in the Diagnosis of Benign and Malignant Thoracic Tumors

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Yan Li ◽  
Yangli Sui ◽  
Mingyan Chi ◽  
Jie Zhang ◽  
Lin Guo
Keyword(s):  
Malignant Tumors ◽  
Compliance Rate ◽  
Breast Tumors ◽  
Diagnostic Value ◽  
Diagnostic Sensitivity ◽  
Good Effect ◽  
Benign Tumors ◽  
Mediastinal Tumors ◽  
Chest Wall Tumors ◽  
Diagnostic Sensitivity And Specificity

In order to investigate the effectiveness and accuracy of magnetic resonance imaging (MRI) in the diagnosis of benign and malignant thoracic tumors, the research retrospectively selected 80 patients with thoracic tumors admitted from May 2019 to May 2020 as the study subject and all patients were underwent MRI detection. Using pathological diagnostic results as the gold standard, the research analyzed the detection of benign and malignant thoracic tumors by MRI, as well as the diagnostic sensitivity and specificity. After pathological diagnosis, there were 35 malignant tumors and 45 benign tumors. 41 cases of malignant tumors and 39 cases of benign tumors were diagnosed by MRI, with a diagnostic sensitivity of 80.00%, a diagnostic specificity of 71.11%, and a diagnostic compliance rate of 75.00%. In the MRI diagnosis of tumors in different parts of the chest, the diagnostic sensitivity for lung tumors, mediastinal tumors, chest wall tumors, and esophageal tumors was 83.33%, 71.43%, 83.33%, 75.00%, and 87.50%, respectively, and the specificity was 66.67%, 77.78%, 57.14%, 50.00%, and 91.67% according to and breast tumors, respectively. And the accuracy was 73.33%, 75.00%, 69.23, 62.50%, and 90.00%, respectively, with the highest diagnostic sensitivity, specificity, and accuracy for breast tumors. MRI has a good effect on the diagnosis of benign and malignant thoracic tumors and has a high diagnostic value, which is helpful to identify the location, nature, source, and lesion scope of the tumor. It is safe and worthy of promotion.

scholarly journals Immunohistochemical Analysis of Na+/K+-ATPase and Bone Morphogenetic Protein-2 Expressions in Both Parenchymal and Stromal Cells from Benign and Malignant Canine Mammary Tumors

2021 ◽  
Author(s):  
ozlem ozmen
Keyword(s):  
Stromal Cells ◽  
Malignant Tumors ◽  
Breast Tumors ◽  
Mammary Tumors ◽  
Bone Morphogenetic Protein 2 ◽  
Mammary Tissue ◽  
Benign Tumors ◽  
Ion Pump ◽  
Human Breast ◽  
Canine Mammary Tumors

Abstract Canine mammary tumors are the most common type of dog tumor, and they are similar to human breast tumors. Na+/K+-ATPase is a common plasma membrane ion pump with important physiological and pathophysiological functions. In mammary tumors, the tumor microenvironment was composed of a heterogeneous population of tumor cells and nearby endogenous stromal cells. Bone morphogenetic proteins (BMPs) regulate fetal development, tissue homeostasis and differentiation, and a variety of cellular functions. The purpose of this study is to examine the immunohistochemical expression of Na+/K+-ATPase and BMP-2 in tumoral and stromal cells from benign and malignant canine mammary tumors. In this study, ten benign and ten malignant mammary tumors from the archives of the Department of Pathology were used, with five normal breast tissues serving as controls. The results of the revealed that tumors had higher levels of Na+/K+-ATPase and BMP-2 expressions than normal mammary tissue. While both markers were expressed negatively or mildly in benign tumors, they increased significantly in malignant tumors. Both Na+/K+-ATPase and BMP-2 are expressed by tumoral and stromal cells in canine mammary tumors. When compared to compared to BMP-2, Na+/K+-ATPase expression was found to be more severe. This study found that Na+/K+-ATPase and BMP-2 can be used as markers of malignancy in canine mammary tumors and that stromal cells also play an important role in tumor progression. These findings also indicated that Na+/K+-ATPase and BMP-2 may be used for early diagnosis or as a potential target for treatment of canine and human breast tumors in the future.

scholarly journals Cardiac masses due to tumors (diagnosis, clinical manifestations and surgical treatment)

2014 ◽  
Vol 95 (6) ◽  
pp. 806-810 ◽  
Author(s):  
D L Kranin
Keyword(s):  
Surgical Treatment ◽  
Malignant Tumors ◽  
Clinical Manifestations ◽  
Surgical Excision ◽  
Benign Tumors ◽  
Cardiac Tumors ◽  
Low Grade ◽  
Imaging Results ◽  
Valvular Heart Diseases ◽  
Cardiac Myxomas

Aim. To summarize the experience on the diagnosis and surgical treatment of primary benign and malignant cardiac tumors. Methods. The paper describes 37 clinical observations of endocavitary primary benign and malignant cardiac tumors: 26 (70.3%) cases of cardiac myxoma, 5 (13.5%) - rhabdomyosarcoma, 2 (5.4%) - angiosarcoma, 1 (2.7% ) - leiomyosarcoma, 1 (2.7%) - fibrosarcoma, 1 (2.7%) - liposarcoma. Patients were 15 (40.5%) males and 22 (59.5%) females aged 18 to 65 years. Endocavitary cardiac tumors were diagnosed by noninvasive tests: echocardiography, computed tomography, magnetic resonance imaging. Results. Patients with primary benign and malignant cardiac tumors had variable clinical manifestations. Symptoms of astenoneurotic syndrome, auscultatory and cardiophonographic signs simulating acquired or congenital valvular heart diseases, which often have a positional relationship; low-grade fever of unknown origin, weight loss were registered. Paraneoplastic syndrome was characterized by an increase in erythrocyte sedimentation rate, leukocytosis, monocytosis, dysproteinemia, polycythemia, hypochromic anemia, increased levels of C-reactive protein. Surgical excision of 25 cardiac myxomas and 8 malignant tumors of the heart was performed with cardiopulmonary bypass, pharmacological cardioplegia and general hypothermia. In 1 case the tumor resection was combined with coronary artery bypass grafting. In 3 patients suffering from malignant tumors, explorative thoracotomy was performed. Surgical revision, emergency and planned microscopic studies of removed cardiac tumors allowed to establish the final clinical diagnosis. Hospital mortality among patients operated for cardiac myxomas was 4.0%, for cardiac malignant tumors - 27.3%. Conclusion. Timely surgical treatment of patients with primary cardiac benign tumors (myxomas) leads to recovery and is accompanied by a relatively low mortality; better results of patients with cardiac endocavitary tumors treatment depend on the early detection and timely radical surgical excision.

Solid Tumors in the Neonatal Period

NeoReviews ◽  
2014 ◽  
Vol 15 (2) ◽  
pp. e56-e68
Author(s):  
Karen S. Fernández
Keyword(s):  
Solid Tumors ◽  
Multidisciplinary Approach ◽  
Neonatal Period ◽  
Malignant Tumors ◽  
Diagnostic Evaluation ◽  
Therapeutic Interventions ◽  
Benign Tumors ◽  
Newborn Period ◽  
General Overview

Solid tumors discovered at birth or during the first month after delivery are rare. Neonatal tumors are often benign. Malignant tumors in neonates represent only 2% of all malignancies in childhood. Some tumors that appear histologically malignant may show benign behavior, whereas apparently benign tumors may be fatal by virtue of their site of origin, which makes neonatal tumors one of the most difficult diagnostic and therapeutic challenges in the neonatal units. Planning the diagnostic evaluation and therapeutic interventions necessitates a multidisciplinary approach that involves the neonatology, radiology, surgery, pathology, hematology, and oncology services. Here we provide a general overview of the most common tumors seen in the newborn period.

Thermal Simulations of Cancerous Breast Tumors and Cysts on a Realistic Female Torso

2021 ◽  
Author(s):  
Francisco J Gonzalez
Keyword(s):  
Clinical Diagnosis ◽  
Computational Models ◽  
Infrared Imaging ◽  
Malignant Tumors ◽  
Diagnostic Technique ◽  
Breast Tumors ◽  
Benign Tumors ◽  
Temperature Pattern ◽  
Thermal Pattern ◽  
Thermal Simulations

Abstract Thermography as a clinical imaging technique has been around for several decades, however it has not become a common diagnostic technique mainly due to its low specificity. The development of computational models of heat transfer in biological tissue can provide a deeper knowledge of healthy and non-healthy thermal patterns could increase the usefulness of thermography in clinical diagnosis. In this work the thermal pattern of cancerous and benign breast tumors are calculated through finite element computer simulations using a realistic female human torso. The simulation results show a thermal pattern which is consistent with infrared images of female subjects and it is not present in simulations performed using other approximate geometries of the breast. A parametric study using cancerous tumors and cysts as a function of size and depth show that the temperature over the skin closest to the tumor decreases for benign tumors while it increases for malignant tumors, also the temperature patterns show a 20% deviation from thermal simulations using a hemispherical breast model. This result indicates that there is a strong geometric component in the human temperature pattern. These results are a first step to understand benign and malignant thermal processes in the breast which might help increase the usefulness of infrared imaging in breast clinical diagnosis.

Retrospective study on parotid gland tumors

ORL ro ◽  
2016 ◽  
Vol 4 (1) ◽  
pp. 22-23
Author(s):  
Ibric Cioranu ◽  
Vlad Petrescu Seceleanu ◽  
Viorel Ibric Cioranu ◽  
Andreea Smarandache ◽  
Sorin Vasilescu ◽  
...  
Keyword(s):  
Malignant Tumors ◽  
Maxillofacial Surgery ◽  
Squamous Carcinoma ◽  
Benign Tumors ◽  
Warthin Tumor ◽  
Parotid Tumors ◽  
Non Hodgkin Lymphoma ◽  
Adenoid Cystic ◽  
Modal Treatment ◽  
Surgery Department

During 2011-2012, 56 patients diagnosed with parotid tumors were admitted to the Maxillofacial Surgery Department of “Lucian Blaga” University and in Euroclinic Hospital. 72% were benign tumors and 28% malignant. All patients received surgical treatment (total or partial parotidectomy). For the malignant tumors, radiotherapy was added to the modal treatment (94% of the cases). Pleomorphic adenoma was encountered in 70% of the benign cases, followed by Warthin tumor in 15%. Adenoid cystic carcinoma was noticed in 31% of the malignant cases, mucoepidermoid carcinoma in 25% of the cases, and squamous carcinoma and non-Hodgkin lymphoma on 12.5% of the malignant cases.  

HISTOLOGICAL DIAGNOSTICS OF MAMMARY GLAND NEOPLASMS IN CATS

2020 ◽  
Keyword(s):  
Mammary Gland ◽  
Malignant Tumors ◽  
Breast Tumors ◽  
Domestic Animals ◽  
Breast Diseases ◽  
Microscopic Studies ◽  
Malignant Breast ◽  
Poorly Differentiated ◽  
Breast Adenocarcinomas

Mammary gland neoplasms in cats are at the top of the list of the most common nosological diseases among domestic animals; more than half of the tumors appear as malignant. Veterinary practitioners have many questions about the prevalence of breast tumors in cats, depending on age, breed and seasons of the year. The article presents the results of diseases prevalence of benign and malignant breast tumors in cats kept in the conditions of Bishkek. The characteristic of macroscopic and microscopic studies of benign and malignant breast tumors in cats at different periods of life and depending on the breed is also described. Studies were conducted in the period from March 2018 to March 2019. Morphological methods were used in the study of breast tumors. As a result of our research, we established the morphological forms of benign and malignant breast tumors in cats. Among benign neoplastic breast diseases in cats, breast lipoma was observed. Also among the malignant tumors of the breast met highly differentiated, moderately differentiated and poorly differentiated breast adenocarcinomas malnutrition and necrosis as well as the rare phylloid (leaf-shaped) fibroadenoma of the mammary gland which makes up only 0.3-0.5 % of all breast tumors.

scholarly journals Multimodality imaging review of focal renal lesions

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Jonathan Lyske ◽  
Rishi Philip Mathew ◽  
Christopher Hutchinson ◽  
Vimal Patel ◽  
Gavin Low
Keyword(s):  
Malignant Tumors ◽  
Multimodality Imaging ◽  
Lymphoproliferative Disease ◽  
Benign Tumors ◽  
Main Body ◽  
Imaging Features ◽  
Focal Lesions ◽  
Renal Lesions ◽  
Positron Emission ◽  
Neoplastic Lesions

Abstract Background Focal lesions of the kidney comprise a spectrum of entities that can be broadly classified as malignant tumors, benign tumors, and non-neoplastic lesions. Malignant tumors include renal cell carcinoma subtypes, urothelial carcinoma, lymphoma, post-transplant lymphoproliferative disease, metastases to the kidney, and rare malignant lesions. Benign tumors include angiomyolipoma (fat-rich and fat-poor) and oncocytoma. Non-neoplastic lesions include infective, inflammatory, and vascular entities. Anatomical variants can also mimic focal masses. Main body of the abstract A range of imaging modalities are available to facilitate characterization; ultrasound (US), contrast-enhanced ultrasound (CEUS), computed tomography (CT), magnetic resonance (MR) imaging, and positron emission tomography (PET), each with their own strengths and limitations. Renal lesions are being detected with increasing frequency due to escalating imaging volumes. Accurate diagnosis is central to guiding clinical management and determining prognosis. Certain lesions require intervention, whereas others may be managed conservatively or deemed clinically insignificant. Challenging cases often benefit from a multimodality imaging approach combining the morphology, enhancement and metabolic features. Short conclusion Knowledge of the relevant clinical details and key imaging features is crucial for accurate characterization and differentiation of renal lesions.

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