TO EVALUATE DECT’S ROLE IN GOUT AND EXAMINE THE RELATIONSHIP WITH CLINICAL AND PARACLINICAL

2019 ◽  
pp. 78-83
Author(s):  
Van Nam Tran ◽  
Tam Vo ◽  
Chi Cuong Nguyen ◽  
Nguyen Thanh Nhan Vo ◽  
Thanh Hai Phan
Keyword(s):  
Computed Tomography ◽  
Bone Structure ◽  
Multivariate Logistic Regression Analysis ◽  
Dual Energy ◽  
Original Research ◽  
Cross Sectional ◽  
Crystal Deposition ◽  
Dual Energy Computed Tomography ◽  
The Relationship ◽  
Urate Crystals

Background: To identify Urate crystals from synovial fluid under polarized microscopy is considered the gold standard in diagnosing Gout disease. However, it is not always possible to suck up enough fluid or in case of pain, it is impossible to suck the fluid. Dual-energy Computed Tomography (DECT) is a new tool for diagnosing Gout disease. DECT shows the deposition of urate crystals and bone structure images using different display colors. However, there is no agreement from the research results in the world. In Vietnam, no original research has been published. Objective: To evaluate DECT’s role in Gout and examine the relationship with clinical and paraclinical factors. Methods: A cross-sectional study was conducted in patients who visited the Hoa Hao-Medic clinic in Ho Chi Minh City. Gout disease is diagnosed with clinical and paraclinical criteria; and have DECT results. The cases were selected continuously, there were no cases of losing samples. Multivariate logistic regression analysis was used to determine the independent association between clinical and paraclinical variables with DECT images. Results: 61 out of 80 Gout patients with DECT positive accounted for 77.25%, There was an association between DECT and number of Gout attacks (> 3 times), duration of illness (> 36 months), tophi seeds. No correlation was found between clinical variables and background characteristics in the study. In the subclinical, urate crystal deposition images show a clear imprint on goute disease, while other variables do not find expression. Conclusion: DECT is closely related to the frequency of gout attacks, disease duration and tophi. Gout disease is a consequence of lifestyle behaviors, inappropriate eating habits, and exposure to risk factors in life. Key words: DECT (Dual-energy Computed Tomography), Hoa Hao-Med, Gout

scholarly journals Distribution of bony erosions in feet and performance of two bone erosion scores: A dual-energy computed tomography study of 61 patients with gout

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0259194
Author(s):  
Amandine Chabernaud Negrier ◽  
Lokmane Taihi ◽  
Eric Vicaut ◽  
Pascal Richette ◽  
Thomas Bardin ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Erosion ◽  
Intraclass Correlation ◽  
Metatarsophalangeal Joint ◽  
Dual Energy ◽  
Radiology Department ◽  
Crystal Deposition ◽  
First Metatarsophalangeal Joint ◽  
Dual Energy Computed Tomography ◽  
Bone Erosions

Objectives To assess the distribution of bone erosions and two erosion scores in the feet of patients with gout and analyze the association between erosion scores and monosodium urate (MSU) crystal deposition using dual-energy computed tomography (DECT). Materials and methods We included all patients who underwent DECT of both feet between 2016 and 2019 in our radiology department, with positive detection of MSU deposits. Data on sex, age, treatment, serum urate, and DECT urate volumes were obtained. CT images were analyzed to score bone erosions in 31 sites per foot by using the semi-quantitative method based on the Rheumatoid Arthritis MRI Scoring (RAMRIS) system and the Dalbeth-simplified score. Reproducibility for the two scores was calculated with intraclass correlation coefficients (ICCs). Correlations between clinical features, erosion scores and urate crystal volume were analyzed by the Spearman correlation coefficient (r). Results We studied 61 patients (mean age 62.0 years); 3,751 bones were scored. The first metatarsophalangeal joint and the midfoot were the most involved in terms of frequency and severity of bone erosions. The distribution of bone erosions was not asymmetrical. The intra- and inter-observer reproducibility was similar for the RAMRIS and Dalbeth-simplified scores (ICC 0.93 vs 0.94 and 0.96 vs 0.90). DECT urate volume was significantly correlated with each of the two erosion scores (r = 0.58–0.63, p < 0.001). There was a high correlation between the two scores (r = 0.96, p < 0.001). Conclusions DECT demonstrates that foot erosions are not asymmetric in distribution and predominate at the first ray and midfoot. The two erosion scores are significantly correlated with DECT urate volume. An almost perfect correlation between the RAMRIS and Dalbeth-simplified scores is observed.

scholarly journals Quantitative Assessment of Thyroid Nodules Using Dual-Energy Computed Tomography: Iodine Concentration Measurement and Multiparametric Texture Analysis for Differentiating between Malignant and Benign Lesions

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Hayato Tomita ◽  
Hirofumi Kuno ◽  
Kotaro Sekiya ◽  
Katharina Otani ◽  
Osamu Sakai ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Texture Analysis ◽  
Thyroid Nodules ◽  
Texture Features ◽  
Iodine Content ◽  
Iodine Concentration ◽  
Dual Energy ◽  
Concentration Measurement ◽  
Cross Sectional ◽  
Dual Energy Computed Tomography

Background and Objectives. Thyroid nodules are increasingly being detected during cross-sectional imaging of the neck and chest. The purpose of this study is to investigate the efficacy of dual-energy computed tomography (DECT) using iodine concentration measurement and multiparametric texture analysis of monochromatic images for differentiating between benign and malignant thyroid nodules. Materials and Methods. This retrospective study included 34 consecutive patients who presented with thyroid nodules and underwent noncontrast DECT between 2015 and 2016. Manual segmentation of each thyroid nodule by monochromatic imaging (40, 60, and 80 keV) was performed, and an in-house developed MATLAB-based texture analysis program was used to extract 41 textures. Iodine material decomposition and CT attenuation slopes were also measured. Histopathologic findings of ultrasound-guided biopsies over a follow-up period of at least one year were used as reference standards. Basic descriptive statistics and areas under receiver operating characteristic curves (AUCs) were evaluated. Results. The 34 nodules comprised 14 benign nodules and 20 malignant nodules. Iodine content and Hounsfield unit curve slopes did not differ significantly between benign and malignant thyroid nodules (P=0.480–0.670). However, significant differences in the texture features of monochromatic images were observed between benign and malignant nodules: histogram mean and median, co-occurrence matrix contrast, gray-level gradient matrix (GLGM) skewness, and mean gradients and variance of gradients for GLGM at 80 keV (P=0.014–0.044). The highest AUC was 0.77, for the histogram mean and median of images acquired at 80 keV. Conclusions. Texture features extracted from monochromatic images using DECT, specifically acquired at high keV, may be a promising diagnostic approach for thyroid nodules. A further large study for incidental thyroid nodules using DECT texture analysis is required to validate our results.

scholarly journals Association of Specific Comorbidities with Monosodium Urate Crystal Deposition in Urate-Lowering Therapy-Naive Gout Patients: A Cross-Sectional Dual-Energy Computed Tomography Study

2020 ◽  
Vol 9 (5) ◽  
pp. 1295
Author(s):  
Tristan Pascart ◽  
André Ramon ◽  
Sébastien Ottaviani ◽  
Julie Legrand ◽  
Vincent Ducoulombier ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Heart Failure ◽  
Computed Tomography ◽  
Chronic Heart Failure ◽  
Dual Energy ◽  
Bivariate Analysis ◽  
Monosodium Urate ◽  
Cross Sectional ◽  
Crystal Deposition ◽  
Lowering Therapy

(1) Background: To determine which factors are associated with the volume of monosodium urate (MSU) crystal deposition quantified by dual-energy computed tomography (DECT) in urate-lowering therapy (ULT)-naive gout patients. (2) Methods: In this multicenter cross-sectional study, DECT scans of knees and feet/ankles were prospectively obtained from ULT-naive gout patients. Demographic, clinical (including gout history and comorbidities), and biological data were collected, and their association with DECT MSU crystal volume was analyzed using bivariate and multivariate analyses. A second bivariate analysis was performed by splitting the dataset depending on an arbitrary threshold of DECT MSU volume (1 cm3). (3) Results: A total of 91 patients were included. In the bivariate analysis, age (p = 0.03), gout duration (p = 0.003), subcutaneous tophi (p = 0.004), hypertension (p = 0.02), diabetes mellitus (p = 0.05), and chronic heart failure (p = 0.03) were associated with the total DECT volume of MSU crystal deposition. In the multivariate analysis, factors associated with DECT MSU volumes ≥1 cm3 were gout duration (odds ratio (OR) for each 10-year increase 3.15 (1.60; 7.63)), diabetes mellitus (OR 4.75 (1.58; 15.63)), and chronic heart failure (OR 7.82 (2.29; 31.38)). (4) Conclusion: Specific comorbidities, particularly chronic heart failure and diabetes mellitus, are more strongly associated with increased MSU crystal deposition in knees and feet/ankles than gout duration, regardless of serum urate level.

Monosodium Urate Crystal Deposition in Coronary Artery Plaque by 128-Slice Dual-Energy Computed Tomography

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Gudrun M. Feuchtner ◽  
Fabian Plank ◽  
Christoph Beyer ◽  
Christoph Schwabl ◽  
Julia Held ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Coronary Artery ◽  
Dual Energy ◽  
Monosodium Urate ◽  
Crystal Deposition ◽  
Coronary Artery Plaque ◽  
Dual Energy Computed Tomography ◽  
Urate Crystal
Sign in / Sign up

Export Citation Format

Share Document