Detection and characterization of manufactured nano-objects in complex matrices. Guide

2015 ◽  
Keyword(s):  
Complex Matrices

Characterization of the Impact of Mixing and Droplet Volumes on the Behavior of Microfluidic Ion-Selective Droptodes

The Analyst ◽  
2021 ◽  
Author(s):  
Shannon Wetzler ◽  
Mark E. Meyerhoff ◽  
Ryan C Bailey
Keyword(s):  
Rapid Detection ◽  
Complex Matrices ◽  
The Impact

Droplet microfluidic optodes, or “droptodes”, have emerged as a powerful technology for rapid detection of small ions in complex matrices. While using segmented aqueous phases provides the benefits of sample...

scholarly journals Towards a new pseudo-quantitative approach to evaluate the ionization response of nitrogen compounds in complex matrices

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Julie Guillemant ◽  
Marion Lacoue-Nègre ◽  
Alexandra Berlioz-Barbier ◽  
Florian Albrieux ◽  
Luis P. de Oliveira ◽  
...  
Keyword(s):  
High Resolution Mass Spectrometry ◽  
Absolute Quantification ◽  
Petroleum Products ◽  
Nitrogen Compounds ◽  
Complex Matrices ◽  
Ft Icr Ms ◽  
Ft Icr ◽  
Ionization Response

AbstractUltra high-resolution mass spectrometry (FT-ICR MS) coupled to electrospray ionization (ESI) provides unprecedented molecular characterization of complex matrices such as petroleum products. However, ESI faces major ionization competition phenomena that prevent the absolute quantification of the compounds of interest. On the other hand, comprehensive two-dimensional gas chromatography (GC × GC) coupled to specific detectors (HRMS or NCD) is able to quantify the main families identified in these complex matrices. In this paper, this innovative dual approach has been used to evaluate the ionization response of nitrogen compounds in gas oils as a case study. To this extent, a large gas oil dataset has been analyzed by GC × GC/HRMS, GC × GC-NCD and ESI(+/−)-FT-ICR MS. Then, the concentrations obtained from GC × GC-NCD have been compared to those obtained from FT-ICR MS hence proving that strong ionization competitions are taking place and also depending on the origin of the sample. Finally, multilinear regressions (MLR) have been used to quantitatively predict nitrogen families from FT-ICR MS measurements as well as start rationalizing the ionization competition phenomena taking place between them in different types of gas oils.

scholarly journals High-throughput antibody screening from complex matrices using intact protein electrospray mass spectrometry

2020 ◽  
Vol 117 (18) ◽  
pp. 9851-9856 ◽  
Author(s):  
William S. Sawyer ◽  
Neha Srikumar ◽  
Joseph Carver ◽  
Phillip Y. Chu ◽  
Amy Shen ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Throughput ◽  
Culture Media ◽  
Intact Protein ◽  
Complex Matrices ◽  
Cell Culture Media ◽  
Relative Quantitation ◽  
Order Of Magnitude ◽  
Selection Of

Toward the goal of increasing the throughput of high-resolution mass characterization of intact antibodies, we developed a RapidFire–mass spectrometry (MS) assay using electrospray ionization. We achieved unprecedented screening throughput as fast as 15 s/sample, which is an order of magnitude improvement over conventional liquid chromatography (LC)-MS approaches. The screening enabled intact mass determination as accurate as 7 ppm with baseline resolution at the glycoform level for intact antibodies. We utilized this assay to characterize and perform relative quantitation of antibody species from 248 samples of 62 different cell line clones at four time points in 2 h using RapidFire–time-of-flight MS screening. The screening enabled selection of clones with the highest purity of bispecific antibody production and the results significantly correlated with conventional LC-MS results. In addition, analyzing antibodies from a complex plasma sample using affinity-RapidFire-MS was also demonstrated and qualified. In summary, the platform affords high-throughput analyses of antibodies, including bispecific antibodies and potential mispaired side products, in cell culture media, or other complex matrices.

Single particle ICP-MS combined with internal standardization for accurate characterization of polydisperse nanoparticles in complex matrices

2020 ◽  
Vol 35 (10) ◽  
pp. 2148-2155
Author(s):  
Yingyan Huang ◽  
Judy Tsz-Shan Lum ◽  
Kelvin Sze-Yin Leung
Keyword(s):  
Mass Spectrometry ◽  
Single Particle ◽  
Inductively Coupled Plasma ◽  
Complex Matrices ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Internal Standardization

Single particle inductively coupled plasma-mass spectrometry (sp-ICP-MS) is becoming a popular tool to analyze nanoparticles.

scholarly journals Partial orders based on the CS decomposition

2020 ◽  
Vol 72 (8) ◽  
pp. 1119-1133
Author(s):  
S. Z. Xu ◽  
J. L. Chen ◽  
J. Benítez
Keyword(s):  
Matrix Decomposition ◽  
Partial Orders ◽  
Complex Matrices ◽  
Matrix Decompositions ◽  
The Core ◽  
Cs Decomposition

UDC 512.5 A new decomposition for square matrices is given by using two known matrix decompositions, a new characterization of the core-EP order is obtained by using this new matrix decomposition. Also, we will use a matrix decomposition to investigate the minus, star, sharp and core partial orders in the setting of complex matrices.

scholarly journals On Minimal Norms onMn

2007 ◽  
Vol 2007 ◽  
pp. 1-4
Author(s):  
Madjid Mirzavaziri ◽  
Mohammad Sal Moslehian
Keyword(s):  
Complex Matrices ◽  
Minimal Norm ◽  
Minimal Algebra

We show that for each minimal normN(⋅)on the algebraℳnof alln×ncomplex matrices, there exist norms‖⋅‖1and‖⋅‖2onℂnsuch thatN(A)=max{‖Ax‖2:‖x‖1=1, x∈ℂn}for allA∈ℳn. This may be regarded as an extension of a known result on characterization of minimal algebra norms.

A Characterization of Intrinsic Functions on

1969 ◽  
Vol 21 ◽  
pp. 136-146 ◽  
Author(s):  
R. E. Carlson ◽  
C. G. Cullen
Keyword(s):  
Associative Algebra ◽  
Simple Algebra ◽  
Complex Matrices ◽  
Full List ◽  
Quaternion Matrices ◽  
Real Quaternions ◽  
Intrinsic Function ◽  
Real Matrices

Let be an associative algebra over the field and let be the group of all automorphisms and anti-automorphisms of which leave elementwise invariant. A function Fwith domain and range contained in is called an intrinsic functionon if (i) for each Ω in and (ii) F(ΩZ) = ΩF(Z) for every Z in .Rinehart (5) has introduced and motivated the study of the class of intrinsic functions on , and has characterized these functions for the cases in which is the algebra of real quaternions, the algebra of n × ncomplex matrices, or the algebra of n× nreal matrices (5; 6). The algebras listed above, along with the algebra of n × nquaternion matrices, constitute the full list of possibilities for the simple direct summands of any semi-simple algebra over or ; see (2).

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