Head and neck impact, burn and noise injury criteria. A Guide for CEN helmet standards committees

2011 ◽  
Keyword(s):  
Head And Neck ◽  
Injury Criteria

Head and Neck Response of an Active Human Body Model and Finite Element Anthropometric Test Device During a Linear Impactor Helmet Test

2019 ◽  
Vol 142 (2) ◽  
Author(s):  
David A. Bruneau ◽  
Duane S. Cronin
Keyword(s):  
Finite Element ◽  
Head And Neck ◽  
Muscle Activation ◽  
Fe Model ◽  
Human Body Model ◽  
Neck Stiffness ◽  
Body Model ◽  
Injury Criteria ◽  
Hybrid Iii ◽  
Primary Impact

Abstract It has been proposed that neck muscle activation may play a role in head response resulting from impacts in American Football. The importance of neck stiffness and active musculature in the standard linear impactor helmet test was assessed using a detailed head and neck finite element (FE) model from a current human body model (HBM) compared to a validated hybrid III head and neck FE model. The models were assessed for bare-head and helmeted impacts at three speeds (5.5, 7.4, and 9.3 m/s) and three impact orientations. The HBM head and neck was assessed without muscle activation and with a high level of muscle activation representing a braced condition. The HBM and hybrid III had an average cross-correlation rating of 0.89 for acceleration in the primary impact direction, indicating excellent correspondence regardless of muscle activation. Differences were identified in the axial head acceleration, attributed to axial neck stiffness (correlation rating of 0.45), but these differences did not have a large effect on the overall head response using existing head response metrics (head injury criteria, brain injury criteria, and head impact power). Although responses that develop over longer durations following the impact differed slightly, such as the moment at the base of the neck, this occurred later in time, and therefore, did not considerably affect the short-term head kinematics in the primary impact direction. Though muscle activation did not play a strong role in the head response for the test configurations considered, muscle activation may play a role in longer duration events.

Head and Neck Injury Risk Criteria-Based Robust Design for Vehicular Crashworthiness

2020 ◽  
Author(s):  
Anand Balu Nellippallil ◽  
Parker R. Berthelson ◽  
Luke Peterson ◽  
Raj K. Prabhu
Keyword(s):  
Head And Neck ◽  
Robust Design ◽  
Injury Risk ◽  
Road Transport ◽  
Neck Injury ◽  
Side Impact ◽  
Transport Systems ◽  
Injury Criteria ◽  
Head And Neck Injury ◽  
The Impact

Abstract Government agencies, globally, often strive to minimize the risk of human death and serious injury on road transport systems. Multi-national projects like Vision Zero have been developed with this objective in mind. Therefore, from an engineering design standpoint, the minimization of these road impact effects on occupants becomes a major design goal. This necessitates a need to quantify and manage injury risks on the human body in terms of different vehicular impact variables and their associated uncertainties for different crash scenarios. In this paper, we present a decision-based robust design framework to quantify and manage the impact-based injury risks on occupants for different computational model-based car crash scenarios. The key functionality offered is the designer’s capability to carry out robust design studies with a focus on managing the selected impact variables and associated uncertainties, such that injury risks are controlled within acceptable levels. The efficacy of the framework is tested for near side impact scenarios with impact velocity and angle of impact as the critical variables of interest. Two injury criteria, namely, Head Injury Criterion (HIC) and Lateral Neck Injury Criteria (Lateral Nij) are selected to quantitatively measure the head and neck injury risks in crash simulations. Using the framework, a robust design problem is formulated to explore the combination of impact variables that best satisfice the injury goals defined. The framework and associated design constructs are generic and support the formulation and decision-based robust design of vehicle impact scenarios for managing injury risks.

Copper-dependent ATP7B up-regulation drives the resistance of TMEM16A-overexpressing head-and-neck cancer models to platinum toxicity

2019 ◽  
Vol 476 (24) ◽  
pp. 3705-3719 ◽  
Author(s):  
Avani Vyas ◽  
Umamaheswar Duvvuri ◽  
Kirill Kiselyov
Keyword(s):  
Oxidative Stress ◽  
Head And Neck ◽  
Transcriptional Activation ◽  
Platinum Resistance ◽  
Mrna Levels ◽  
Strong Positive Correlation ◽  
Platinum Compounds ◽  
Copper Chelation ◽  
Novel Approach ◽  
Cancer Models

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.

Intubation during manual in-line stabilisation of the head and neck

Anaesthesia ◽  
2000 ◽  
Vol 55 (8) ◽  
pp. 814-814 ◽  
Author(s):  
R. M. Dravid ◽  
M. Popat
Keyword(s):  
Head And Neck
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