Stationary source emissions. Determination of the mass concentration of total gaseous organic carbon at low concentrations in flue gases. Continuous flame ionization detector method

1999 ◽  
Keyword(s):  
Organic Carbon ◽  
Mass Concentration ◽  
Flame Ionization Detector ◽  
Flue Gases ◽  
Ionization Detector ◽  
Stationary Source ◽  
Flame Ionization ◽  
Low Concentrations ◽  
Detector Method

A gas chromatography flame ionization detector method for rapid simultaneous separation and determination of six active ingredients of anticold drug

2021 ◽  
Vol 17 ◽  
Author(s):  
Fatang Yang ◽  
Xiaoyun Duan ◽  
Zhen Wang ◽  
Yuming Dong
Keyword(s):  
Gas Chromatography ◽  
Simultaneous Determination ◽  
Limit Of Detection ◽  
Flame Ionization Detector ◽  
Gas Chromatograph ◽  
Ionization Detector ◽  
Active Ingredients ◽  
Flame Ionization ◽  
Detector Method

Aims: To establish a rapid and simultaneous determination of multiple effective ingredients in anti-cold drugs. Background: Anti-cold drugs are stock medicines at home, and most anti-cold formulations are compound preparations. Although the active ingredients of compound preparations have significant effects on the treatment of colds, the excessive dosage or long-term use can produce a series of adverse reactions including dependence, liver and kidney function damage, digestive system reaction, blood system damage. Now, there are many mature methods for analyzing the active ingredients of anti-cold drugs. However, these methods may have shortcomings such as a long analysis time or a small number of analysis components. Objective: Establish a gas chromatography-flame ionization detector method for the simultaneous determination of six active ingredients including acetaminophen, dextromethorphan hydrobromide, pseudoephedrine hydrochloride, chlorpheniramine maleate, diphenhydramine hydrochloride, and caffeine in anti-cold drugs. Method: After the standard was accurately weighed, dissolved in ethanol, filtered by 0.22 μm membrane and ultrasonically degassed, the gas chromatograph was used for detection. After the actual sample was removed from the coating, ground and crushed, accurately weighed, dissolved in ethanol, filtered by 0.22 μm membrane and ultrasonically degassed, the gas chromatograph was used for detection. Result: The six components can be completely separated within 7.0min. This method has good sensitivity, precision, accuracy and recovery rate. Under the optimum testing conditions, the limit of detection was 0.360-2.50μg/mL, the limit of quantification was 1.20-8.30μg/mL. The calibration curves showed good linearity (R2≥0.9932) over the investigated concentration range between 1.20 and 400μg/mL. The recoveries were 89.2% to 109.2%. The RSD of intra-day precision was less than 1.0%. The RSD of inter-day precision was less than 3.2%. The established method was used to determine the ingredients of three anti-cold drugs on the market, and the results showed that the method can accurately determine the ingredients. Conclusion: The method can quickly and simultaneously determine multiple active ingredients in anti-cold medicines. Compared with the published methods in literatures, the proposed method has the advantages of fast, the number of analysis componentswide application range, convenience, low cost, etc. It provides a reference method for quality control of active ingredients of anti-cold drugs.

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