Development and validation of a new gas flame ionization detector method for the determination of finasteride in tablets

2006 ◽  
Vol 352 (2) ◽  
pp. 260-264 ◽  
Author(s):  
Serap Sağlık ◽  
Sevgi Tatar Ulu
Keyword(s):  
Flame Ionization Detector ◽  
Ionization Detector ◽  
Flame Ionization ◽  
Detector Method ◽  
Gas Flame ◽  
Development And Validation

A gas chromatography flame ionization detector method for rapid simultaneous separation and determination of six active ingredients of anticold drug

2021 ◽  
Vol 17 ◽  
Author(s):  
Fatang Yang ◽  
Xiaoyun Duan ◽  
Zhen Wang ◽  
Yuming Dong
Keyword(s):  
Gas Chromatography ◽  
Simultaneous Determination ◽  
Limit Of Detection ◽  
Flame Ionization Detector ◽  
Gas Chromatograph ◽  
Ionization Detector ◽  
Active Ingredients ◽  
Flame Ionization ◽  
Detector Method

Aims: To establish a rapid and simultaneous determination of multiple effective ingredients in anti-cold drugs. Background: Anti-cold drugs are stock medicines at home, and most anti-cold formulations are compound preparations. Although the active ingredients of compound preparations have significant effects on the treatment of colds, the excessive dosage or long-term use can produce a series of adverse reactions including dependence, liver and kidney function damage, digestive system reaction, blood system damage. Now, there are many mature methods for analyzing the active ingredients of anti-cold drugs. However, these methods may have shortcomings such as a long analysis time or a small number of analysis components. Objective: Establish a gas chromatography-flame ionization detector method for the simultaneous determination of six active ingredients including acetaminophen, dextromethorphan hydrobromide, pseudoephedrine hydrochloride, chlorpheniramine maleate, diphenhydramine hydrochloride, and caffeine in anti-cold drugs. Method: After the standard was accurately weighed, dissolved in ethanol, filtered by 0.22 μm membrane and ultrasonically degassed, the gas chromatograph was used for detection. After the actual sample was removed from the coating, ground and crushed, accurately weighed, dissolved in ethanol, filtered by 0.22 μm membrane and ultrasonically degassed, the gas chromatograph was used for detection. Result: The six components can be completely separated within 7.0min. This method has good sensitivity, precision, accuracy and recovery rate. Under the optimum testing conditions, the limit of detection was 0.360-2.50μg/mL, the limit of quantification was 1.20-8.30μg/mL. The calibration curves showed good linearity (R2≥0.9932) over the investigated concentration range between 1.20 and 400μg/mL. The recoveries were 89.2% to 109.2%. The RSD of intra-day precision was less than 1.0%. The RSD of inter-day precision was less than 3.2%. The established method was used to determine the ingredients of three anti-cold drugs on the market, and the results showed that the method can accurately determine the ingredients. Conclusion: The method can quickly and simultaneously determine multiple active ingredients in anti-cold medicines. Compared with the published methods in literatures, the proposed method has the advantages of fast, the number of analysis componentswide application range, convenience, low cost, etc. It provides a reference method for quality control of active ingredients of anti-cold drugs.

Determination of Phenothiazine and Several of its Derivatives by Gas-Liquid Chromatography

1966 ◽  
Vol 49 (4) ◽  
pp. 857-859
Author(s):  
C L Bramlett
Keyword(s):  
Liquid Chromatography ◽  
Internal Standard ◽  
Flame Ionization Detector ◽  
Gas Liquid Chromatography ◽  
Chromatographic Technique ◽  
Ionization Detector ◽  
Flame Ionization ◽  
Hydrogen Flame

Abstract Phenothiazine, promethazine.HCl, chlorpromazine. HCl, promazine.HCl, and levomepromazine. HCl were chromatographed satisfactorily on a column containing 5% Apiezon L coated on Anakrom ABS, 100/110 mesh, using a hydrogen-flame ionization detector. This gas chromatographic technique is rapid and more specific than existing official methods. The use of an internal standard to improve precision will be investigated.

Rapid Gas-Chromatographic Determination of Amphetamine and Methamphetamine in Urine

1974 ◽  
Vol 20 (11) ◽  
pp. 1460-1462 ◽  
Author(s):  
Naresh C Jain ◽  
Thomas C Sneath ◽  
Robert D Budd
Keyword(s):  
Gas Chromatography ◽  
Quantitative Result ◽  
Chromatographic Determination ◽  
Flame Ionization Detector ◽  
Specific Method ◽  
Ionization Detector ◽  
Rapid Procedure ◽  
Flame Ionization ◽  
Dual Analysis

Abstract A simple, rapid procedure is described for measuring amphetamine and methamphetamine in urine by gas chromatography, with use of a flame ionization detector. This method is sensitive to subtherapeutic concentrations (0.1 µg/ml or less), and is especially useful in clinical situations where an accurate and quantitative result is needed in less than 30 min. With the method, amphetamine and methamphetamine can be determined as the free bases on a 10% Apiezon L-10% KOH column and as their trifluoroacetamide derivatives on a 3% OV-17 column. This dual analysis eliminates false positives and any interfering substances that may be present in the urine, and is thus a specific method for the two drugs.

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