Biotechnology. Modified organisms for application in the environment. Guidance for the characterization of the genetically modified organism by analysis of the molecular stability of the genomic modification

1998 ◽  
Keyword(s):  
Genetically Modified ◽  
Genetically Modified Organism ◽  
Molecular Stability

scholarly journals Production of Certified Reference Materials for the Detection of Genetically Modified Organisms

2002 ◽  
Vol 85 (3) ◽  
pp. 775-779 ◽  
Author(s):  
Stefanie Trapmann ◽  
Heinz Schimmel ◽  
Gerard Nico Kramer ◽  
Guy van den Eede ◽  
Jean Pauwels
Keyword(s):  
Reference Materials ◽  
Genetically Modified Organisms ◽  
Production Control ◽  
Certified Reference Materials ◽  
Genetically Modified ◽  
Base Material ◽  
Genetically Modified Organism ◽  
International Organization ◽  
Roundup Ready

Abstract Certified reference materials (CRMs) are an essential tool in the quality assurance of analytical measurements. They are produced, certified, and used in accordance with relevant ISO (International Organization for Standardization) and BCR (Community Bureau of Reference) guidelines. The Institute for Reference Materials and Measurements (IRMM; Geel, Belgium) has produced the first powdery genetically modified organism (GMO) CRMs in cooperation with the Institute for Health and Consumer Protection (Ispra, Italy). Until now, different weight percentages in the range of 0–5%for 4 GMOs in Europe were produced and certified: Bt (Bacillus thuringiensis)-11 and Bt-176 maize, Roundup Ready® soybean, and MON810 maize. Bt-11 and Bt-176 maize and Roundup Ready soybean were produced by IRMM on behalf of Fluka Chemie AG (Buchs, Switzerland). Characterization of used base material is the first step in production and is especially important for GMO CRMs. The production of powdery GMO CRMs and methods used for production control are described. Thorough control of homogeneity and stability are essential for certification of reference materials and ensure validity of the certificate for each bottle of a batch throughout a defined shelf-life. Because production of reference materials and their maintenance are very labor- and cost-intensive tasks, the usefulness of new types of GMO CRMs must be estimated carefully.

scholarly journals How to Do What Is Right, Not What Is Easy: Requirements for Assessment of Genome-Edited and Genetically Modified Organisms under Ethical Guidelines

Food Ethics ◽  
2021 ◽  
Vol 6 (2) ◽  
Author(s):  
T. Antonsen ◽  
T. Dassler
Keyword(s):  
Genetically Modified Organisms ◽  
Practical Knowledge ◽  
Genetically Modified ◽  
Genetically Modified Organism ◽  
Ethical Guidelines ◽  
Complex Dynamic ◽  
Ethical Assessment ◽  
Ethical Expertise ◽  
Range Of Values

Summary/AbstractAn ethical assessment is a complex, dynamic and comprehensive process that requires both ethical expertise and practical knowledge. An ethical assessment of a genetically modified organism (GMO, including genome edited organisms) must follow accepted and transparent methods and be based in relevant considerations. In addition, the Ethical guidelines must include a broad and adequate range of values, so that no groups, stakeholders, agents or areas are left out.

scholarly journals Characterization of Cross-Protection by Genetically Modified Live-AttenuatedLeishmania donovaniParasites againstLeishmania mexicana

2014 ◽  
Vol 193 (7) ◽  
pp. 3513-3527 ◽  
Author(s):  
Ranadhir Dey ◽  
Gayathri Natarajan ◽  
Parna Bhattacharya ◽  
Hannah Cummings ◽  
Pradeep K. Dagur ◽  
...  
Keyword(s):  
Genetically Modified ◽  
Cross Protection
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