On development of rational design guidelines for large side-inlet side-outlet perforated element mufflers

2018 ◽  
Vol 66 (4) ◽  
pp. 308-323
Author(s):  
K.M. Kumar ◽  
M.L. Munjal
Keyword(s):  
Rational Design ◽  
Design Guidelines ◽  
Side Outlet ◽  
Large Side

scholarly journals Population Design for Synthetic Gene Circuits

2021 ◽  
pp. 181-197
Author(s):  
Baptiste Turpin ◽  
Eline Y. Bijman ◽  
Hans-Michael Kaltenbach ◽  
Jörg Stelling
Keyword(s):  
Computer Aided Design ◽  
Rational Design ◽  
Design Method ◽  
Industrial Applications ◽  
Design Guidelines ◽  
Synthetic Gene Circuits ◽  
Ode Models ◽  
Nonlinear Mixed Effect ◽  
Reliable Performance ◽  
Cell To Cell Variability

AbstractSynthetic biologists use and combine diverse biological parts to build systems such as genetic circuits that perform desirable functions in, for example, biomedical or industrial applications. Computer-aided design methods have been developed to help choose appropriate network structures and biological parts for a given design objective. However, they almost always model the behavior of the network in an average cell, despite pervasive cell-to-cell variability. Here, we present a computational framework to guide the design of synthetic biological circuits while accounting for cell-to-cell variability explicitly. Our design method integrates a NonLinear Mixed-Effect (NLME) framework into an existing algorithm for design based on ordinary differential equation (ODE) models. The analysis of a recently developed transcriptional controller demonstrates first insights into design guidelines when trying to achieve reliable performance under cell-to-cell variability. We anticipate that our method not only facilitates the rational design of synthetic networks under cell-to-cell variability, but also enables novel applications by supporting design objectives that specify the desired behavior of cell populations.

scholarly journals Conveyor-Belt Dryers with Tangential Flow for Food Drying: Mathematical Modeling and Design Guidelines for Final Moisture Content Higher Than the Critical Value

Inventions ◽  
2020 ◽  
Vol 5 (2) ◽  
pp. 22
Author(s):  
Dario Friso
Keyword(s):  
Mathematical Modeling ◽  
Moisture Content ◽  
Rational Design ◽  
Conveyor Belt ◽  
Design Guidelines ◽  
Final Moisture Content ◽  
Temperature Sensitive ◽  
Optimized Design ◽  
Tangential Flow ◽  
Product Flow

The mathematical modeling presented in this work concerns the conveyor-belt dryer with the tangential flow of air with respect to food. This dryer, if operating in co-current, has the advantage of well preserving the organoleptic and nutritional qualities of the dried product. In fact, it has a low air temperature in the final stretch where the product has low moisture content and is therefore more temperature sensitive. It is a bulkier dryer than the continuous through-circulation conveyor dryer with a perforated belt. The latter is therefore more frequently used and has received greater study attention from researchers and designers of the industry. With the aim to propose guidelines for a rational design of the conveyor-belt dryer with tangential flow, a mathematical model was developed here through the differentiation of the drying rate equation followed by its integration performed along the dryer belt. Consequently, and with the assumption that the final moisture content XF of the product is higher than the critical moisture content XC, the relationships between the intensive quantities (temperatures, humidity and enthalpies), the extensive quantities (air and product flow rates) and the dimensional ones (length and width of the belt), were obtained. Finally, on the basis of these relationships, the rules for an optimized design for XF > XC were obtained and experimentally evaluated.

Preliminary Finite Element Analyses on Seismic Resistant FREE from DAMage Beam to Column Joints under Impact Loading

2018 ◽  
Vol 763 ◽  
pp. 592-599 ◽  
Author(s):  
Marina D'Antimo ◽  
Mariana Zimbru ◽  
Mario D'Aniello ◽  
Jean François Demonceau ◽  
Jean Pierre Jaspart ◽  
...  
Keyword(s):  
Finite Element ◽  
Impact Loading ◽  
Rational Design ◽  
Design Guidelines ◽  
Dissipative Systems ◽  
Finite Element Analyses ◽  
Steel Moment Resisting Frames ◽  
Structural Robustness ◽  
Moment Resisting ◽  
Push Down

Nowadays, the interest on structural robustness is increasing because of the recent terroristic attacks. Although a large number of research projects have been carried out in this field, limited design guidelines as well as code recommendations are nowadays available. Leading to the fact that the design for robustness is far from being current practice. Conversely, the design for natural hazards as the earthquake is a well-consolidated practice and modern codes implement effective and well-recognized design rules. Even though seismic design philosophy based on the concept of hierarchy of resistance enables structural robustness for conventional structural systems, this is not demonstrated for structures equipped with anti-seismic devices as well as innovative dissipative systems. Recently, the use of friction based dissipative joints has been proved to be a promising solution for seismically design steel moment resisting frames. However, the robustness and the resistance against impact loading of this type of joints is not yet investigated. With the aim to develop an experimental campaign based on impact tests, preliminary finite element analyses have been carried out to identify the main criticisms and to drive the rational design of the joint specimens. With this regard, in the present paper, the results of a numerical parametric study on the preliminary push-down test are presented and discussed.

Rational design of hybridization chain reaction monomers for robust signal amplification

2016 ◽  
Vol 52 (22) ◽  
pp. 4219-4222 ◽  
Author(s):  
Yan Shan Ang ◽  
Lin-Yue Lanry Yung
Keyword(s):  
Signal Amplification ◽  
Rational Design ◽  
Design Guidelines ◽  
Hybridization Chain Reaction ◽  
Chain Reaction

Four-point design guidelines for generating robust hybridization chain reaction (HCR) hairpin sequences were established and successfully implemented for FRET readout.

scholarly journals Engineering Translational Resource Allocation Controllers: Mechanistic Models, Design Guidelines, and Potential Biological Implementations

2018 ◽  
Author(s):  
Alexander P.S. Darlington ◽  
Juhyun Kim ◽  
José I. Jiménez ◽  
Declan G. Bates
Keyword(s):  
Gene Expression ◽  
Resource Allocation ◽  
Rational Design ◽  
Controller Design ◽  
Mechanistic Model ◽  
Design Guidelines ◽  
Negative Effects ◽  
Trade Off ◽  
Resource Limitations ◽  
Synthetic Gene Circuits

AbstractThe use of orthogonal ribosomes in combination with dynamic resource allocation controllers is a promising approach for relieving the negative effects of cellular resource limitations on the modularity of synthetic gene circuits. Here, we develop a detailed mechanistic model of gene expression and resource allocation, which when simplified to a tractable level of complexity, allows the rational design of translational resource allocation controllers. Analysis of this model reveals a fundamental design trade-off; that reducing coupling acts to decrease gene expression. Through a sensitivity analysis of the experimentally tuneable controller parameters, we identify how each controller design parameter affects the overall closed-loop behaviour of the system, leading to a detailed set of design guidelines for optimally managing this trade-off. Based on our designs, we evaluated a number of alternative potential experimental implementations of the proposed system using commonly available biological components. Finally, we show that the controller is capable of dynamically allocating ribosomes as needed to restore modularity in a number of more complex synthetic circuits, such as the repressilator, and activation cascades composed of multiple interacting modules.

Development of a rational design methodology for precast concrete slender spandrel beams: Part 2, analysis and design guidelines

PCI Journal ◽  
2011 ◽  
Vol 56 (4) ◽  
pp. 106-133 ◽  
Author(s):  
Gregory Lucier ◽  
Catrina Walter ◽  
Sami Rizkalla ◽  
Paul Zia ◽  
Gary Klein
Keyword(s):  
Design Methodology ◽  
Rational Design ◽  
Precast Concrete ◽  
Design Guidelines ◽  
Analysis And Design

Asphalt Plug Joints: Refined Material Tests and Design Guidelines

2000 ◽  
Vol 1740 (1) ◽  
pp. 126-134 ◽  
Author(s):  
Brian K. Bramel ◽  
Charles W. Dolan ◽  
Jay A. Puckett ◽  
Khaled Ksaibati
Keyword(s):  
Rational Design ◽  
Slight Modification ◽  
The United States ◽  
Standard Test ◽  
Design Guidelines ◽  
Full Scale ◽  
Critical Material ◽  
Expansion Joints ◽  
Departments Of Transportation ◽  
Material Tests

Highway builders and rehabilitators throughout the United States use asphalt plug joints (APJs) in bridge expansion joints according to manufacturers’ recommendations. Joint performance varies widely, as indicated in recent surveys. State departments of transportation are installing joints in unsuitable sites or are overlooking other sites where APJs may work well. Rational design guidelines for APJs have been developed. The research suggests suitable applications, material characterization, design guidelines, and validation procedures. Two critical material properties are required to qualify APJ material: relaxation and glass-transition temperature. Both properties may be obtained by using a slight modification of the AASHTO standard thermal specimen, restrained specimen asphalt test. This modified standard test was conducted, and the results were compared with those of the near-full-scale test. Design guidelines are based on field observations, material tests, near-full-scale testing, analytical evaluations, and a survey of the experiences of state departments of transportation. Design recommendations are provided, and joint design changes are proposed to help mitigate the present shortcomings.

scholarly journals One-step synthesis of ball-shaped metal complexes with a main absorption band in the near-IR region

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Taniyuki Furuyama ◽  
Fumika Shimasaki ◽  
Natsumi Saikawa ◽  
Hajime Maeda ◽  
Masahito Segi
Keyword(s):  
Absorption Band ◽  
Metal Ion ◽  
Rational Design ◽  
Solar Spectrum ◽  
Design Guidelines ◽  
Absorption Bands ◽  
Main Absorption Band ◽  
Near Ir ◽  
One Step ◽  
Ir Light

Abstract The design of near-IR materials is highly relevant to energy and pharmaceutical sciences due to the high proportion of near-IR irradiation in the solar spectrum and the high penetration of near-IR light in biological samples. Here, we show the one-step synthesis of hexacoordinated ruthenium and iron complexes that exhibit a main absorption band in the near-IR region. For that purpose, novel tridentate ligands were prepared by condensation of two diimines and four cyanoaryl derivatives in the presence of ruthenium and iron template ions. This method was applied to a wide variety of cyanoaryl, diimine, and metal ion combinations. The relationship between the structure and the optical and electrochemical properties in the resulting complexes was examined, and the results demonstrated that these compounds represent novel near-IR materials whose physical properties can be controlled based on rational design guidelines. The intense absorption bands in the 700–900 nm region were assigned to metal-to-ligand charge transfer (MLCT) transitions, which should allow applications in materials with triplet excited states under irradiation with near-IR light.

Molecular insights on the dynamic stability of peptide nucleic acid functionalized carbon and boron nitride nanotubes

2021 ◽  
Vol 23 (1) ◽  
pp. 219-228
Author(s):  
Nabanita Saikia ◽  
Mohamed Taha ◽  
Ravindra Pandey
Keyword(s):  
Nucleic Acid ◽  
Boron Nitride ◽  
Nucleic Acids ◽  
Dynamic Stability ◽  
Peptide Nucleic Acid ◽  
Rational Design ◽  
Peptide Nucleic Acids ◽  
Boron Nitride Nanotubes ◽  
Molecular Hybrids ◽  
Single Wall Nanotubes

The rational design of self-assembled nanobio-molecular hybrids of peptide nucleic acids with single-wall nanotubes rely on understanding how biomolecules recognize and mediate intermolecular interactions with the nanomaterial's surface.

Optimizing electron density of nickel sulfide electrocatalysts through sulfur vacancy engineering for alkaline hydrogen evolution

2020 ◽  
Vol 8 (35) ◽  
pp. 18207-18214
Author(s):  
Dongbo Jia ◽  
Lili Han ◽  
Ying Li ◽  
Wenjun He ◽  
Caichi Liu ◽  
...  
Keyword(s):  
Hydrogen Evolution ◽  
Electron Density ◽  
Rational Design ◽  
Nickel Sulfide ◽  
Catalytic Performance ◽  
Sulfide Catalysts ◽  
Sulfur Vacancy

A novel, rational design for porous S-vacancy nickel sulfide catalysts with remarkable catalytic performance for alkaline HER.

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