Rational design of hybridization chain reaction monomers for robust signal amplification

2016 ◽  
Vol 52 (22) ◽  
pp. 4219-4222 ◽  
Author(s):  
Yan Shan Ang ◽  
Lin-Yue Lanry Yung
Keyword(s):  
Signal Amplification ◽  
Rational Design ◽  
Design Guidelines ◽  
Hybridization Chain Reaction ◽  
Chain Reaction

Four-point design guidelines for generating robust hybridization chain reaction (HCR) hairpin sequences were established and successfully implemented for FRET readout.

Target-directed enzyme-free dual-amplification DNA circuit for rapid signal amplification

2020 ◽  
Vol 8 (47) ◽  
pp. 10770-10775
Author(s):  
Chao Xing ◽  
Ziyi Chen ◽  
Cheng Zhang ◽  
Jun Wang ◽  
Chunhua Lu
Keyword(s):  
Nucleic Acids ◽  
Small Molecules ◽  
Signal Amplification ◽  
Fluorescence Analysis ◽  
Single Step ◽  
Hybridization Chain Reaction ◽  
Chain Reaction ◽  
Dual Amplification

An enzyme-free, single-step and rapid signal amplification DNA circuit was developed by integrating target-directed entropy-driven catalysis and hybridization chain reaction for fluorescence analysis of nucleic acids and small molecules.

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