scholarly journals Relationship between rs4674344 CYP27A1 gene polymorphism and coronary artery disease in Polish population

2019 ◽  
Author(s):  
Joanna Iwanicka ◽  
Tomasz Iwanicki ◽  
Anna Balcerzyk ◽  
Paweł Niemiec ◽  
Tomasz Nowak ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Gene Polymorphism ◽  
Polish Population ◽  
Artery Disease

Ghrelin gene polymorphism (Arg51Gln) is not associated with coronary artery disease

2016 ◽  
Vol 72 (3) ◽  
Author(s):  
Akbar Hedayatizadeh-omran ◽  
Alireza Rafiei ◽  
Reza Alizadeh-Navaei ◽  
Rezvan Khajavi ◽  
Abulghasem Ajami ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Gene Polymorphism ◽  
Ghrelin Gene ◽  
Artery Disease

scholarly journals Association of TNF-α (-308G/A) Gene Polymorphism with Circulating TNF-α Levels and Excessive Daytime Sleepiness in Adults with Coronary Artery Disease and Concomitant Obstructive Sleep Apnea

2021 ◽  
Vol 10 (15) ◽  
pp. 3413
Author(s):  
Afrouz Behboudi ◽  
Tilia Thelander ◽  
Duygu Yazici ◽  
Yeliz Celik ◽  
Tülay Yucel-Lindberg ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Obstructive Sleep Apnea ◽  
Coronary Artery ◽  
Sleep Apnea ◽  
Gene Polymorphism ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Obstructive Sleep ◽  
Tnf Α ◽  
Artery Disease

Obstructive sleep apnea (OSA) is common in patients with coronary artery disease (CAD), in which inflammatory activity has a crucial role. The manifestation of OSA varies significantly between individuals in clinical cohorts; not all adults with OSA demonstrate the same set of symptoms; i.e., excessive daytime sleepiness (EDS) and/or increased levels of inflammatory biomarkers. The further exploration of the molecular basis of these differences is therefore essential for a better understanding of the OSA phenotypes in cardiac patients. In this current secondary analysis of the Randomized Intervention with Continuous Positive Airway Pressure in CAD and OSA (RICCADSA) trial (Trial Registry: ClinicalTrials.gov; No: NCT 00519597), we aimed to address the association of tumor necrosis factor alpha (TNF-α)-308G/A gene polymorphism with circulating TNF-α levels and EDS among 326 participants. CAD patients with OSA (apnea–hypopnea-index (AHI) ≥ 15 events/h; n = 256) were categorized as having EDS (n = 100) or no-EDS (n = 156) based on the Epworth Sleepiness Scale score with a cut-off of 10. CAD patients with no-OSA (AHI < 5 events/h; n = 70) were included as a control group. The results demonstrated no significant differences regarding the distribution of the TNF-α alleles and genotypes between CAD patients with vs. without OSA. In a multivariate analysis, the oxygen desaturation index and TNF-α genotypes from GG to GA and GA to AA as well as the TNF-α-308A allele carriage were significantly associated with the circulating TNF-α levels. Moreover, the TNF-α-308A allele was associated with a decreased risk for EDS (odds ratio 0.64, 95% confidence interval 0.41–0.99; p = 0.043) independent of age, sex, obesity, OSA severity and the circulating TNF-α levels. We conclude that the TNF-α-308A allele appears to modulate circulatory TNF-α levels and mitigate EDS in adults with CAD and concomitant OSA.

scholarly journals Transcription factor 21 gene polymorphism in patients with coronary artery disease

2017 ◽  
Vol Volume 8 ◽  
pp. 13-18
Author(s):  
Waleed Abdou Hamed ◽  
Ghada E Hammouda ◽  
Sally M El-Hefnawy ◽  
Eman M Abd El-Gayed
Keyword(s):  
Coronary Artery Disease ◽  
Transcription Factor ◽  
Coronary Artery ◽  
Gene Polymorphism ◽  
Artery Disease

ApoE gene polymorphism and its relationship with coronary artery disease in ethnic Kashmiri population

2015 ◽  
Vol 16 (4) ◽  
pp. 551-556 ◽  
Author(s):  
Dil Afroze ◽  
Adfar Yousuf ◽  
Nisar A Tramboo ◽  
Zaffar A. Shah ◽  
Asrar Ahmad
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Gene Polymorphism ◽  
Apoe Gene ◽  
Kashmiri Population ◽  
Artery Disease ◽  
Apoe Gene Polymorphism
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