In vitro and in vivo toxicological evaluation of emissions from the fused filament fabrication three-dimensional printing

2021 ◽  
Author(s):  
Mariana T Farcas
Keyword(s):  
Three Dimensional ◽  
Fused Filament Fabrication ◽  
Toxicological Evaluation ◽  
Three Dimensional Printing ◽  
Dimensional Printing

scholarly journals Biocompatibility of Bespoke 3D-Printed Titanium Alloy Plates for Treating Acetabular Fractures

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Xuezhi Lin ◽  
Xingling Xiao ◽  
Yimeng Wang ◽  
Cheng Gu ◽  
Canbin Wang ◽  
...  
Keyword(s):  
Titanium Alloy ◽  
Culture Medium ◽  
Three Dimensional ◽  
Acetabular Fractures ◽  
Three Dimensional Printing ◽  
3D Printed ◽  
Manufacturing Techniques ◽  
Dimensional Printing

Treatment of acetabular fractures is challenging, not only because of its complicated anatomy but also because of the lack of fitting plates. Personalized titanium alloy plates can be fabricated by selective laser melting (SLM) but the biocompatibility of these three-dimensional printing (3D-printed) plates remains unknown. Plates were manufactured by SLM and their cytocompatibility was assessed by observing the metabolism of L929 fibroblasts incubated with culture medium extracts using a CCK-8 assay and their morphology by light microscopy. Allergenicity was tested using a guinea pig maximization test. In addition, acute systemic toxicity of the 3D-printed plates was determined by injecting extracts from the implants into the tail veins of mice. Finally, the histocompatibility of the plates was investigated by implanting them into the dorsal muscles of rabbits. The in vitro results suggested that cytocompatibility of the 3D-printed plates was similar to that of conventional plates. The in vivo data also demonstrated histocompatibility that was comparable between the two manufacturing techniques. In conclusion, both in vivo and in vitro experiments suggested favorable biocompatibility of 3D-printed titanium alloy plates, indicating that it is a promising option for treatment of acetabular fractures.

scholarly journals Development of 3D-Printed, Liquisolid and Directly Compressed Glimepiride Tablets, Loaded with Black Seed Oil Self-Nanoemulsifying Drug Delivery System: In Vitro and In Vivo Characterization

2022 ◽  
Vol 15 (1) ◽  
pp. 68
Author(s):  
Tarek A. Ahmed ◽  
Hanadi A. Alotaibi ◽  
Waleed S. Alharbi ◽  
Martin K. Safo ◽  
Khalid M. El-Say
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Seed Oil ◽  
Three Dimensional ◽  
Three Dimensional Printing ◽  
Black Seed Oil ◽  
Compression Characteristics ◽  
Dimensional Printing

Glimepiride is characterized by an inconsistent dissolution and absorption profile due to its limited aqueous solubility. The aim of this study was to develop glimepiride tablets using three different manufacturing techniques, as well as to study their quality attributes and pharmacokinetics behavior. Black seed oil based self-nanoemulsifying drug delivery system (SNEDDS) formulation was developed and characterized. Glimepiride liquisolid and directly compressed tablets were prepared and their pre-compression and post-compression characteristics were evaluated. Semi-solid pastes loaded with SNEDDS were prepared and used to develop three-dimensional printing tablets utilizing the extrusion technique. In vivo comparative pharmacokinetics study was conducted on Male Wistar rats using a single dose one-period parallel design. The developed SNEDDS formulation showed a particle size of 45.607 ± 4.404 nm, and a glimepiride solubility of 25.002 ± 0.273 mg/mL. All the studied tablet formulations showed acceptable pre-compression and post-compression characteristics and a difference in their in vitro drug release behavior. The surface of the liquisolid and directly compressed tablets was smooth and non-porous, while the three-dimensional printing tablets showed a few porous surfaces. The inner structure of the liquisolid tablets showed some cracks and voids between the incorporated tablet ingredients while that of the three-dimensional printing tablets displayed some tortuosity and a gel porous-like structure. Most of the computed pharmacokinetic parameters improved with the liquisolid and three-dimensional printed tablets. The relative bioavailabilities of the three-dimensional printed and liquisolid tablets compared to commercial product were 121.68% and 113.86%, respectively. Therefore, the liquisolid and three-dimensional printed tablets are promising techniques for modifying glimepiride release and improving in vivo performance but more clinical investigations are required.

Anti-Reflux Ureteral Stent with Polymeric Flap Valve Using Three-Dimensional Printing: An In Vitro Study

2015 ◽  
Vol 29 (8) ◽  
pp. 933-938 ◽  
Author(s):  
Chang-Ju Park ◽  
Hyeon-Woo Kim ◽  
Sangdo Jeong ◽  
Seungwan Seo ◽  
Yangkyu Park ◽  
...  
Keyword(s):  
Three Dimensional ◽  
In Vitro Study ◽  
Vitro Study ◽  
Ureteral Stent ◽  
Three Dimensional Printing ◽  
Dimensional Printing ◽  
Flap Valve

Study on Biodegradable Implant with Poly (l-Lactic Acid) and its Releasing Character In Vitro

2011 ◽  
Vol 236-238 ◽  
pp. 2744-2747
Author(s):  
Wei Dong Huang ◽  
Sheng Fang Li ◽  
Tao Zou ◽  
Xian You Xia
Keyword(s):  
Three Dimensional ◽  
Environmental Scanning ◽  
Biodegradable Implant ◽  
Three Dimensional Printing ◽  
Novel Technique ◽  
Single Form ◽  
Conventional Technology ◽  
Dimensional Printing ◽  
Scanning Electron

To elucidate the effects of implants fabricated by three-dimensional printing (3DP) technologies, a novel technique enables the complex implant release profiles, precise dosage control and rapid formulation in a single form. In this study, a unique implant with polylactic acid-based polymer powders was developed by the process. Test of the morphology and the releasing experiments in vitro of the implants were done to evaluate the implant devices. At about 100-day release of the implants in vitro, the drug concentration was measured and the profiles were made. The morphology of the implants of both technologies was characterized by three dimensional stereoscopy and environmental scanning electron microscope. The release behaviour and the microstructure were detected to compare the effects. 3DP technology allows the design and fabrication of implants with a novel micro- and macro-architecture which cannot be fabricated or may be fabricated with many difficulties in conventional technology.

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