scholarly journals Investigation of Molecular Functions of Zinc Finger Protein (ZNF71) in Non- Small Cell Lung Cancer

2020 ◽  
Author(s):  
Rehab O Mohamed
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Zinc Finger ◽  
Cell Lung Cancer ◽  
Zinc Finger Protein ◽  
Small Cell ◽  
Small Cell Lung ◽  
Finger Protein ◽  
Molecular Functions

scholarly journals Molecular Analysis of ZNF71 KRAB in Non-Small-Cell Lung Cancer

2021 ◽  
Vol 22 (7) ◽  
pp. 3752
Author(s):  
Qing Ye ◽  
Rehab Mohamed ◽  
Duaa Dukhlallah ◽  
Marieta Gencheva ◽  
Gangqing Hu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lines ◽  
Zinc Finger ◽  
Cell Lung Cancer ◽  
Zinc Finger Protein ◽  
Small Cell ◽  
Nsclc Cell ◽  
Small Cell Lung ◽  
Mesenchymal Transition

Our previous study found that zinc finger protein 71 (ZNF71) mRNA expression was associated with chemosensitivity and its protein expression was prognostic of non-small-cell lung cancer (NSCLC). The Krüppel associated box (KRAB) transcriptional repression domain is commonly present in human zinc finger proteins, which are linked to imprinting, silencing of repetitive elements, proliferation, apoptosis, and cancer. This study revealed that ZNF71 KRAB had a significantly higher expression than the ZNF71 KRAB-less isoform in NSCLC tumors (n = 197) and cell lines (n = 117). Patients with higher ZNF71 KRAB expression had a significantly worse survival outcome than patients with lower ZNF71 KRAB expression (log-rank p = 0.04; hazard ratio (HR): 1.686 [1.026, 2.771]), whereas ZNF71 overall and KRAB-less expression levels were not prognostic in the same patient cohort. ZNF71 KRAB expression was associated with epithelial-to-mesenchymal transition (EMT) in both patient tumors and cell lines. ZNF71 KRAB was overexpressed in NSCLC cell lines resistant to docetaxel and paclitaxel treatment compared to chemo-sensitive cell lines, consistent with its association with poor prognosis in patients. Therefore, ZNF71 KRAB isoform is a more effective prognostic factor than ZNF71 overall and KRAB-less expression for NSCLC. Functional analysis using CRISPR-Cas9 and RNA interference (RNAi) screening data indicated that a knockdown/knockout of ZNF71 did not significantly affect NSCLC cell proliferation in vitro.

scholarly journals Ring finger protein 38 promote non-small cell lung cancer progression by endowing cell EMT phenotype

2018 ◽  
Vol 9 (5) ◽  
pp. 841-850 ◽  
Author(s):  
Dian Xiong ◽  
Shu-Qiang Zhu ◽  
Yong-Bing Wu ◽  
Chun Jin ◽  
Jia-Hao Jiang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Progression ◽  
Cell Lung Cancer ◽  
Ring Finger ◽  
Small Cell ◽  
Ring Finger Protein ◽  
Small Cell Lung ◽  
Finger Protein

scholarly journals Expression of LUN gene that encodes a novel RING finger protein is correlated with development and progression of non-small cell lung cancer

Lung Cancer ◽  
2004 ◽  
Vol 46 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Hiroki Oyanagi ◽  
Kazumasa Takenaka ◽  
Shinya Ishikawa ◽  
Yozo Kawano ◽  
Yoshifumi Adachi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Ring Finger ◽  
Small Cell ◽  
Ring Finger Protein ◽  
Small Cell Lung ◽  
Finger Protein
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