scholarly journals Physiological, Developmental, and Biomarker Responses of Zebrafish Embryos to Sub-Lethal Exposure of Bendiocarb

Water ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 204
Author(s):  
Gyöngyi Gazsi ◽  
Zsolt Czimmerer ◽  
Bence Ivánovics ◽  
Izabella Roberta Berta ◽  
Béla Urbányi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heart Rate ◽  
Adverse Effects ◽  
Life Stage ◽  
Larval Growth ◽  
Aquatic Organisms ◽  
Early Life Stage ◽  
World Health ◽  
Reduced Body ◽  
Health Organization

Bendiocarb is a broad-spectrum insecticide recommended for malaria control by the World Health Organization (WHO). Still, bendiocarb poses a toxic risk to populations of nontargeted aquatic organisms. Thus, our study was aimed to evaluate the sub-lethal effects of bendiocarb exposure on zebrafish (Danio rerio) embryos by assessing of physiological, developmental, and biochemical parameters. Bendiocarb-induced adverse effects on embryonic development, larval growth, heart rate, changes in phase II detoxifying enzyme glutathione-S-transferase (GST) activity, oxidative stress-related enzyme activities (superoxide dismutase (SOD), catalase (CAT)), and the damage-linked biomarker lipid peroxidation (LPO) in early life stage zebrafish were investigated. Our results highlight that the selected nonlethal concentrations (96 h median lethal concentration in this study was 32.52 mg/L−1) of bendiocarb inflicted adverse effects resulting in embryo deformities (96 h EC50 = 2.30 mg L−1), reduced body- and notochord length (above 0.75 and 0.39 mg L−1 bendiocarb concentrations at 96 hpf, respectively), oxidative stress, and altered heart rate (above 0.4 mg L−1 at 48 hpf) in the studied model system.

Some Physicochemical Parameters of Wastewater from an Oil Industry at Point of Discharge in Port Harcourt, Rivers State, Nigeria

2020 ◽  
Vol 6 (2) ◽  
pp. 23-28
Author(s):  
O. A. F Wokoma ◽  
◽  
O. S Edori ◽  
Keyword(s):  
Physicochemical Parameters ◽  
Oxygen Demand ◽  
Aquatic Organisms ◽  
Oil Industry ◽  
World Health ◽  
Port Harcourt ◽  
Water Association ◽  
Wastewater Samples ◽  
Health Organization ◽  
Rivers State

Wastewater samples were collected from an oil industry at the point of discharge for a period of two years, from January 2018 – December 2019. The wastewater samples were analyzed for different physicochemical parameters such as temperature, turbidity, total dissolved solids (TDS), total suspended solids (TSS), conductivity, pH, alkalinity, salinity, total hydrocarbon content (THC), biochemical oxygen demand (BOD) and chemical oxygen demand (COD) to examine their conformity to fulfill requirements as recommended by World Health Organization (WHO), Federal Ministry of Environment (FME) and Drinking Water Association (DWA). The results indicated that all the parameters in the discharged wastewater were within acceptable limits of the regulatory bodies. The field data showed that the investigated firm conformed to the law by carrying out proper procedures before discharging the effluents into the public drain and river. Therefore, the release of wastewater from the industry doesn't constitute a danger to the environment as well as aquatic organisms. Keywords: Physicochemical parameter, wastewater discharge, oil industry, environment, contaminants

Chemistry of Iodinated Contrast Media (ICM): A Minireview

2020 ◽  
Vol 17 ◽  
Author(s):  
Maithili Pramod Joshi ◽  
Ameya Chaudhari ◽  
Prashant S. Kharkar ◽  
Shreerang V. Joshi
Keyword(s):  
Adverse Effects ◽  
Contrast Media ◽  
Aqueous Solubility ◽  
Synthetic Methods ◽  
Essential Medicines ◽  
World Health ◽  
Iodinated Contrast Media ◽  
Environmental Aspects ◽  
Iodinated Contrast ◽  
Health Organization

: Historically, the use of Iodinated Contrast Media (ICM) for diagnostic purposes, particularly radiography and computed tomography (CT), is well-known. Many of the ICM are included in the World Health Organization (WHO)’s List of Essential Medicines. Depending on the chemotype and the presence of ionizable functional group(s), the ICM are categorized in the ionic/nonionic monomers/dimers. The lipophilicity, aqueous solubility, viscosity and osmolality are major characteristics dictating their use for one procedure versus the other. Over last several decades, substantial advancement occurred in the design and development of novel ICM, solely to reduce their propensity to cause adverse effects. Given the nature of their acute usage, some of the agents with appreciable toxicity are still used. Understanding their chemistry aspects is crucial to appreciate, acknowledge and justify the usage of these extremely important torch-bearers of diagnostic agent’s class. The present review article presents an in-depth overview of the synthetic methods, therapeutic indications, potential adverse effects along with the commercial and environmental aspects of ICM. The safety and tolerability of these agents is a field that has gained significant importance, which is given due importance in the discussion.

scholarly journals Optimal Length of Heart Rate Variability Data and Forecasting Time for Ventricular Fibrillation Prediction Using Machine Learning

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Da Un Jeong ◽  
Getu Tadele Taye ◽  
Han-Jeong Hwang ◽  
Ki Moo Lim
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Ventricular Fibrillation ◽  
World Health ◽  
Artificial Neural Network Classifier ◽  
Life Threatening ◽  
Causes Of Mortality ◽  
Health Organization ◽  
Forecast Time ◽  
Data Length

Ventricular fibrillation (VF) is a cardiovascular disease that is one of the major causes of mortality worldwide, according to the World Health Organization. Heart rate variability (HRV) is a biomarker that is used for detecting and predicting life-threatening arrhythmias. Predicting the occurrence of VF in advance is important for saving patients from sudden death. We extracted features from seven HRV data lengths to predict the onset of VF before nine different forecast times and observed the prediction accuracies. By using only five features, an artificial neural network classifier was trained and validated based on 10-fold cross-validation. Maximum prediction accuracies of 88.18% and 88.64% were observed at HRV data lengths of 10 and 20 s, respectively, at a forecast time of 0 s. The worst prediction accuracy was recorded at an HRV data length of 70 s and a forecast time of 80 s. Our results showed that features extracted from HRV signals near the VF onset could yield relatively high VF prediction accuracies.

scholarly journals A mathematical modeling approach to risk assessment for normal and anemic women chronically exposed to carbon monoxide from biomass-fueled cookstoves

2011 ◽  
Vol 111 (2) ◽  
pp. 473-484 ◽  
Author(s):  
Eugene N. Bruce ◽  
Margaret C. Bruce ◽  
Kinnera Erupaka-Chada
Keyword(s):  
Mathematical Model ◽  
Carbon Monoxide ◽  
Adverse Effects ◽  
World Health ◽  
Chronic Anemia ◽  
Artery Disease ◽  
Health Organization ◽  
Clinical Conditions ◽  
Physiologic Responses ◽  
Significant Health

In developing countries, the chronic exposure to carbon monoxide (CO) from biomass-fueled cookstoves may pose a significant health risk for women who use these stoves, especially for those with underlying clinical conditions that impair tissue oxygenation, e.g., anemia and coronary artery disease. CO concentrations measured in the vicinity of these cookstoves often exceed World Health Organization (WHO) indoor air guidelines for an 8-h average (9 ppm) and a 1-h maximum (26 ppm). Carboxyhemoglobin levels, reported infrequently because they are difficult to obtain, often exceed the WHO threshold of 2.5%. Despite this evidence, specific adverse effects have not yet been linked with chronic CO exposures in these women. Furthermore, anemia, which is prevalent in populations that use biomass fuels, could exacerbate the adverse effects of chronic CO exposure. Because of the difficulties inherent in conducting prospective studies to address this issue, we used a mathematical model to calculate the effects of reported CO levels and exercise on carboxyhemoglobin for women living in 1) Guatemalan villages at altitudes of 4,429–4,593 ft, and 2) coastal villages in Pakistan. In addition, we used the model to calculate the effects of CO exposures in women with moderate to severe anemia on specific physiological parameters (carboxyhemoglobin, carboxymyoglobin, cardiac output, and tissue Po2) at exercise levels representing the activities in which these women would be engaged. Our results demonstrate the efficacy of using a mathematical model to predict the physiologic responses to CO and also demonstrate that chronic anemia is a critically important determinant of CO toxicity in these women.

scholarly journals Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1562 ◽  
Author(s):  
Mohammed Iddir ◽  
Alex Brito ◽  
Giulia Dingeo ◽  
Sofia Sosa Fernandez Del Campo ◽  
Hanen Samouda ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Immune System ◽  
Nutrient Status ◽  
Short Chain Fatty Acids ◽  
World Health ◽  
Adequate Diet ◽  
Micronutrient Status ◽  
Anti Inflammatory ◽  
Health Organization ◽  
And Oxidative Stress

The coronavirus-disease 2019 (COVID-19) was announced as a global pandemic by the World Health Organization. Challenges arise concerning how to optimally support the immune system in the general population, especially under self-confinement. An optimal immune response depends on an adequate diet and nutrition in order to keep infection at bay. For example, sufficient protein intake is crucial for optimal antibody production. Low micronutrient status, such as of vitamin A or zinc, has been associated with increased infection risk. Frequently, poor nutrient status is associated with inflammation and oxidative stress, which in turn can impact the immune system. Dietary constituents with especially high anti-inflammatory and antioxidant capacity include vitamin C, vitamin E, and phytochemicals such as carotenoids and polyphenols. Several of these can interact with transcription factors such as NF-kB and Nrf-2, related to anti-inflammatory and antioxidant effects, respectively. Vitamin D in particular may perturb viral cellular infection via interacting with cell entry receptors (angiotensin converting enzyme 2), ACE2. Dietary fiber, fermented by the gut microbiota into short-chain fatty acids, has also been shown to produce anti-inflammatory effects. In this review, we highlight the importance of an optimal status of relevant nutrients to effectively reduce inflammation and oxidative stress, thereby strengthening the immune system during the COVID-19 crisis.

scholarly journals A Review of Dietary Zinc Recommendations

2016 ◽  
Vol 37 (4) ◽  
pp. 443-460 ◽  
Author(s):  
Rosalind S. Gibson ◽  
Janet C. King ◽  
Nicola Lowe
Keyword(s):  
Food Safety ◽  
Life Stage ◽  
World Health ◽  
Institute Of Medicine ◽  
Dietary Zinc ◽  
Zinc Bioavailability ◽  
Body Weights ◽  
The Us ◽  
Zinc Nutrition ◽  
Health Organization

Background: Large discrepancies exist among the dietary zinc recommendations set by expert groups. Objective: To describe the basis for the differences in the dietary zinc recommendations set by the World Health Organization, the US Institute of Medicine, the International Zinc Nutrition Consultative Group, and the European Food Safety Agency. Methods: We compared the sources of the data, the concepts, and methods used by the 4 expert groups to set the physiological requirements for absorbed zinc, the dietary zinc requirements (termed estimated and/or average requirements), recommended dietary allowances (or recommended nutrient intakes or population reference intakes), and tolerable upper intake levels for selected age, sex, and life-stage groups. Results: All 4 expert groups used the factorial approach to estimate the physiological requirements for zinc. These are based on the estimates of absorbed zinc required to offset all obligatory zinc losses plus any additional requirements for absorbed zinc for growth, pregnancy, or lactation. However, discrepancies exist in the reference body weights used, studies selected, approaches to estimate endogenous fecal zinc (EFZ) losses, the adjustments applied to derive dietary zinc requirements that take into account zinc bioavailability in the habitual diets, number of dietary zinc recommendations set, and the nomenclature used to describe them. Conclusions: Estimates for the physiological and dietary requirements varied across the 4 expert groups. The European Food Safety Agency was the only expert group that set dietary zinc recommendations at 4 different levels of dietary phytate for adults (but not for children) and as of yet no tolerable upper intake level for any life-stage group.

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