scholarly journals Can Antiretroviral Drugs Be Used to Treat Porcine Endogenous Retrovirus (PERV) Infection after Xenotransplantation?

Viruses ◽  
2017 ◽  
Vol 9 (8) ◽  
pp. 213 ◽  
Author(s):  
Joachim Denner
Keyword(s):  
Endogenous Retrovirus ◽  
Antiretroviral Drugs ◽  
Porcine Endogenous Retrovirus

scholarly journals Susceptibility of the Porcine Endogenous Retrovirus to Reverse Transcriptase and Protease Inhibitors

2001 ◽  
Vol 75 (2) ◽  
pp. 1048-1053 ◽  
Author(s):  
Shoukat H. Qari ◽  
Saema Magre ◽  
J. Gerardo Garcı́a-Lerma ◽  
Althaf I. Hussain ◽  
Yasuhiro Takeuchi ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Protease Inhibitors ◽  
Relative Sensitivity ◽  
Endogenous Retrovirus ◽  
Antiretroviral Drugs ◽  
Clinical Use ◽  
Human Donor ◽  
Gag Polyprotein ◽  
Porcine Endogenous Retrovirus ◽  
Hiv 1

ABSTRACT Porcine xenografts may offer a solution to the shortage of human donor allografts. However, all pigs contain the porcine endogenous retrovirus (PERV), raising concerns regarding the transmission of PERV and the possible development of disease in xenotransplant recipients. We evaluated 11 antiretroviral drugs licensed for human immunodeficiency virus type 1 (HIV-1) therapy for their activities against PERV to assess their potential for clinical use. Fifty and 90% inhibitory concentrations (IC50s and IC90s, respectively) of five nucleoside reverse transcriptase inhibitors (RTIs) were determined enzymatically for PERV and for wild-type (WT) and RTI-resistant HIV-1 reference isolates. In a comparison of IC50s, the susceptibilities of PERV RT to lamivudine, stavudine, didanosine, zalcitabine, and zidovudine were reduced >20-fold, 26-fold, 6-fold, 4-fold, and 3-fold, respectively, compared to those of WT HIV-1. PERV was also resistant to nevirapine. Tissue culture-based, single-round infection assays using replication-competent virus confirmed the relative sensitivity of PERV to zidovudine and its resistance to all other RTIs. A Gag polyprotein-processing inhibition assay was developed and used to assess the activities of protease inhibitors against PERV. No inhibition of PERV protease was seen with saquinavir, ritonavir, indinavir, nelfinavir, or amprenavir at concentrations >200-fold the IC50s for WT HIV-1. Thus, following screening of many antiretroviral agents, our findings support only the potential clinical use of zidovudine.

scholarly journals Human SAMHD1 restricts the xenotransplantation relevant porcine endogenous retrovirus (PERV) in non-dividing cells

2019 ◽  
Vol 100 (4) ◽  
pp. 656-661 ◽  
Author(s):  
Hussein Al-Shehabi ◽  
Uwe Fiebig ◽  
Juliane Kutzner ◽  
Joachim Denner ◽  
Torsten Schaller ◽  
...  
Keyword(s):  
Endogenous Retrovirus ◽  
Porcine Endogenous Retrovirus ◽  
Dividing Cells

Measurement and Destruction of Porcine Endogenous Retrovirus in the Chinese Bama Minipig

2022 ◽  
Author(s):  
Bingqi Zhang ◽  
Mengyu Gao ◽  
Wanliu Peng ◽  
Shengfu Li ◽  
Guangneng Liao ◽  
...  
Keyword(s):  
Endogenous Retrovirus ◽  
Porcine Endogenous Retrovirus

Porcine endogenous retrovirus does not infect human cells using a bioartificial liver model system

2001 ◽  
Vol 33 (1-2) ◽  
pp. 1780-1781 ◽  
Author(s):  
E Falasca ◽  
V Adami ◽  
G Astori ◽  
A Donini ◽  
F Biffoni ◽  
...  
Keyword(s):  
Endogenous Retrovirus ◽  
Bioartificial Liver ◽  
Model System ◽  
Human Cells ◽  
Liver Model ◽  
Porcine Endogenous Retrovirus

LACK OF CROSS-SPECIES TRANSMISSION OF PORCINE ENDOGENOUS RETROVIRUS INFECTION TO NONHUMAN PRIMATE RECIPIENTS OF PORCINE CELLS, TISSUES, OR ORGANS1

2001 ◽  
Vol 71 (7) ◽  
pp. 959-965 ◽  
Author(s):  
William M. Switzer ◽  
Robert E. Michler ◽  
Vedapuri Shanmugam ◽  
Aprille Matthews ◽  
Althaf I. Hussain ◽  
...  
Keyword(s):  
Nonhuman Primate ◽  
Endogenous Retrovirus ◽  
Porcine Endogenous Retrovirus ◽  
Retrovirus Infection
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