scholarly journals Long-Term Single-Dose Efficacy of a Vesicular Stomatitis Virus-Based Andes Virus Vaccine in Syrian Hamsters

Viruses ◽  
2014 ◽  
Vol 6 (2) ◽  
pp. 516-523 ◽  
Author(s):  
Joseph Prescott ◽  
Blair DeBuysscher ◽  
Kyle Brown ◽  
Heinz Feldmann
Keyword(s):  
Single Dose ◽  
Vesicular Stomatitis Virus ◽  
Virus Vaccine ◽  
Syrian Hamsters ◽  
Andes Virus ◽  
Vesicular Stomatitis

scholarly journals Immunization with vesicular stomatitis virus vaccine expressing the Ebola glycoprotein provides sustained long-term protection in rodents

Vaccine ◽  
2014 ◽  
Vol 32 (43) ◽  
pp. 5722-5729 ◽  
Author(s):  
Gary Wong ◽  
Jonathan Audet ◽  
Lisa Fernando ◽  
Hugues Fausther-Bovendo ◽  
Judie B. Alimonti ◽  
...  
Keyword(s):  
Vesicular Stomatitis Virus ◽  
Virus Vaccine ◽  
Vesicular Stomatitis

scholarly journals The vesicular stomatitis virus-based Ebola virus vaccine: From concept to clinical trials

2018 ◽  
Vol 14 (9) ◽  
pp. 2107-2113 ◽  
Author(s):  
Ellen Suder ◽  
Wakako Furuyama ◽  
Heinz Feldmann ◽  
Andrea Marzi ◽  
Emmie de Wit
Keyword(s):  
Clinical Trials ◽  
Vesicular Stomatitis Virus ◽  
Virus Vaccine ◽  
Ebola Virus ◽  
Vesicular Stomatitis

scholarly journals Vesicular Stomatitis Virus-Based Vaccine Protects Hamsters against Lethal Challenge with Andes Virus

2011 ◽  
Vol 85 (23) ◽  
pp. 12781-12791 ◽  
Author(s):  
K. S. Brown ◽  
D. Safronetz ◽  
A. Marzi ◽  
H. Ebihara ◽  
H. Feldmann
Keyword(s):  
Vesicular Stomatitis Virus ◽  
Lethal Challenge ◽  
Andes Virus ◽  
Vesicular Stomatitis

scholarly journals Vesicular Stomatitis Virus-Based Vaccines Provide Cross-Protection against Andes and Sin Nombre Viruses

Viruses ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 645 ◽  
Author(s):  
Bryce M Warner ◽  
Derek R Stein ◽  
Rohit K Jangra ◽  
Megan M Slough ◽  
Patrycja Sroga ◽  
...  
Keyword(s):  
Vesicular Stomatitis Virus ◽  
Cross Protection ◽  
Sin Nombre Virus ◽  
Andes Virus ◽  
High Fatality Rate ◽  
Heterologous Challenge ◽  
Causative Agents ◽  
Vesicular Stomatitis ◽  
Multiple Species ◽  
Reactive Antibody

Andes virus (ANDV) and Sin Nombre virus (SNV) are the main causative agents responsible for hantavirus cardiopulmonary syndrome (HCPS) in the Americas. HCPS is a severe respiratory disease with a high fatality rate for which there are no approved therapeutics or vaccines available. Some vaccine approaches for HCPS have been tested in preclinical models, but none have been tested in infectious models in regard to their ability to protect against multiple species of HCPS-causing viruses. Here, we utilize recombinant vesicular stomatitis virus-based (VSV) vaccines for Andes virus (ANDV) and Sin Nombre virus (SNV) and assess their ability to provide cross-protection in infectious challenge models. We show that, while both rVSVΔG/ANDVGPC and rVSVΔG/SNVGPC display attenuated growth as compared to wild type VSV, each vaccine is able to induce a cross-reactive antibody response. Both vaccines protected against both homologous and heterologous challenge with ANDV and SNV and prevented HCPS in a lethal ANDV challenge model. This study provides evidence that the development of a single vaccine against HCPS-causing hantaviruses could provide protection against multiple agents.

An optimized vaccine vector based on recombinant vesicular stomatitis virus gives high-level, long-term protection against Yersinia pestis challenge

Vaccine ◽  
2007 ◽  
Vol 25 (4) ◽  
pp. 741-750 ◽  
Author(s):  
Amy Palin ◽  
Anasuya Chattopadhyay ◽  
Steven Park ◽  
Guillaume Delmas ◽  
Rema Suresh ◽  
...  
Keyword(s):  
Yersinia Pestis ◽  
Vesicular Stomatitis Virus ◽  
Vaccine Vector ◽  
Vesicular Stomatitis ◽  
High Level

scholarly journals Vesicular stomatitis virus vectors expressing avian influenza H5 HA induce cross-neutralizing antibodies and long-term protection

Virology ◽  
2007 ◽  
Vol 366 (1) ◽  
pp. 166-173 ◽  
Author(s):  
Jennifer A. Schwartz ◽  
Linda Buonocore ◽  
Anjeanette Roberts ◽  
Amorsolo Suguitan ◽  
Darwyn Kobasa ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Vesicular Stomatitis Virus ◽  
Neutralizing Antibodies ◽  
Virus Vectors ◽  
Vesicular Stomatitis

scholarly journals Peri-exposure protection against Nipah virus disease using a single-dose recombinant vesicular stomatitis virus-based vaccine

npj Vaccines ◽  
2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Blair L DeBuysscher ◽  
Dana Scott ◽  
Tina Thomas ◽  
Heinz Feldmann ◽  
Joseph Prescott
Keyword(s):  
Single Dose ◽  
Vesicular Stomatitis Virus ◽  
Virus Disease ◽  
Nipah Virus ◽  
Vesicular Stomatitis

scholarly journals Vesicular Stomatitis Virus Genomic RNA Persists In Vivo in the Absence of Viral Replication

2009 ◽  
Vol 84 (7) ◽  
pp. 3280-3286 ◽  
Author(s):  
Ian D. Simon ◽  
Nico van Rooijen ◽  
John K. Rose
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Viral Replication ◽  
Vesicular Stomatitis Virus ◽  
Genomic Rna ◽  
Intramuscular Inoculation ◽  
Vesicular Stomatitis ◽  
High Level

ABSTRACT Our previous studies using intranasal inoculation of mice with vesicular stomatitis virus (VSV) vaccine vectors showed persistence of vector genomic RNA (gRNA) for at least 60 days in lymph nodes in the absence of detectable infectious virus. Here we show high-level concentration of virus and gRNA in lymph nodes after intramuscular inoculation of mice with attenuated or single-cycle VSV vectors as well as long-term persistence of gRNA in the lymph nodes. To determine if the persistence of gRNA was due to ongoing viral replication, we developed a tagged-primer approach that was critical for detection of VSV mRNA specifically. Our results show that VSV gRNA persists long-term in the lymph nodes while VSV mRNA is present only transiently. Because VSV transcription is required for replication, our results indicate that persistence of gRNA does not result from continuing viral replication. We also performed macrophage depletion studies that are consistent with initial trapping of VSV gRNA largely in lymph node macrophages and subsequent persistence elsewhere in the lymph node.

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