scholarly journals Vesicular Stomatitis Virus-Based Vaccines Provide Cross-Protection against Andes and Sin Nombre Viruses

Viruses ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 645 ◽  
Author(s):  
Bryce M Warner ◽  
Derek R Stein ◽  
Rohit K Jangra ◽  
Megan M Slough ◽  
Patrycja Sroga ◽  
...  
Keyword(s):  
Vesicular Stomatitis Virus ◽  
Cross Protection ◽  
Sin Nombre Virus ◽  
Andes Virus ◽  
High Fatality Rate ◽  
Heterologous Challenge ◽  
Causative Agents ◽  
Vesicular Stomatitis ◽  
Multiple Species ◽  
Reactive Antibody

Andes virus (ANDV) and Sin Nombre virus (SNV) are the main causative agents responsible for hantavirus cardiopulmonary syndrome (HCPS) in the Americas. HCPS is a severe respiratory disease with a high fatality rate for which there are no approved therapeutics or vaccines available. Some vaccine approaches for HCPS have been tested in preclinical models, but none have been tested in infectious models in regard to their ability to protect against multiple species of HCPS-causing viruses. Here, we utilize recombinant vesicular stomatitis virus-based (VSV) vaccines for Andes virus (ANDV) and Sin Nombre virus (SNV) and assess their ability to provide cross-protection in infectious challenge models. We show that, while both rVSVΔG/ANDVGPC and rVSVΔG/SNVGPC display attenuated growth as compared to wild type VSV, each vaccine is able to induce a cross-reactive antibody response. Both vaccines protected against both homologous and heterologous challenge with ANDV and SNV and prevented HCPS in a lethal ANDV challenge model. This study provides evidence that the development of a single vaccine against HCPS-causing hantaviruses could provide protection against multiple agents.

scholarly journals Vesicular Stomatitis Virus-Based Vaccine Protects Hamsters against Lethal Challenge with Andes Virus

2011 ◽  
Vol 85 (23) ◽  
pp. 12781-12791 ◽  
Author(s):  
K. S. Brown ◽  
D. Safronetz ◽  
A. Marzi ◽  
H. Ebihara ◽  
H. Feldmann
Keyword(s):  
Vesicular Stomatitis Virus ◽  
Lethal Challenge ◽  
Andes Virus ◽  
Vesicular Stomatitis

scholarly journals Single Immunization With a Monovalent Vesicular Stomatitis Virus–Based Vaccine Protects Nonhuman Primates Against Heterologous Challenge With Bundibugyo ebolavirus

2011 ◽  
Vol 204 (suppl_3) ◽  
pp. S1082-S1089 ◽  
Author(s):  
Darryl Falzarano ◽  
Friederike Feldmann ◽  
Allen Grolla ◽  
Anders Leung ◽  
Hideki Ebihara ◽  
...  
Keyword(s):  
Vesicular Stomatitis Virus ◽  
Nonhuman Primates ◽  
Heterologous Challenge ◽  
Vesicular Stomatitis

scholarly journals Potent Vesicular Stomatitis Virus-Based Avian Influenza Vaccines Provide Long-Term Sterilizing Immunity against Heterologous Challenge

2010 ◽  
Vol 84 (9) ◽  
pp. 4611-4618 ◽  
Author(s):  
Jennifer A. Schwartz ◽  
Linda Buonocore ◽  
Amorsolo L. Suguitan ◽  
Alex Silaghi ◽  
Darwyn Kobasa ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Vesicular Stomatitis Virus ◽  
Neutralizing Antibodies ◽  
H5n1 Avian Influenza Virus ◽  
H5n1 Avian Influenza ◽  
Heterologous Challenge ◽  
Vesicular Stomatitis ◽  
Clade 1 ◽  
Pandemic Vaccine ◽  
Sterilizing Immunity

ABSTRACT The emergence in 1997 and continuance today of a highly lethal H5N1 avian influenza virus (AIV) causing human disease has raised concern about an impending pandemic and the need for a vaccine to prepare for such an occurrence. We previously generated an efficacious vesicular stomatitis virus (VSV)-based AIV vaccine expressing H5 hemagglutinin (HA) from the fifth genomic position of VSV (J. A. Schwartz et al., Virology 366:166-173, 2007). Here we have generated and characterized VSV-based vaccines that express the A/Hong Kong/156/1997 (clade 0) H5 HA from the first position of the VSV genome. These vectors induce broadly cross-neutralizing antibodies against homologous and heterologous H5N1 viruses of different clades in mice. The vaccines provide complete protection against morbidity and mortality after heterologous challenge with clade 0 and clade 1 strains in animals even 1 year after vaccination. Postchallenge pulmonary virus loads show that these vectors provide sterilizing immunity. Therefore, VSV-based AIV vaccines are potent, broadly cross-protective pandemic vaccine candidates.

scholarly journals Long-Term Single-Dose Efficacy of a Vesicular Stomatitis Virus-Based Andes Virus Vaccine in Syrian Hamsters

Viruses ◽  
2014 ◽  
Vol 6 (2) ◽  
pp. 516-523 ◽  
Author(s):  
Joseph Prescott ◽  
Blair DeBuysscher ◽  
Kyle Brown ◽  
Heinz Feldmann
Keyword(s):  
Single Dose ◽  
Vesicular Stomatitis Virus ◽  
Virus Vaccine ◽  
Syrian Hamsters ◽  
Andes Virus ◽  
Vesicular Stomatitis

626: Initial Experience with Vesicular Stomatitis Virus as a Treatment for Bladder Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 202-202
Author(s):  
Sherwin Zargaroff ◽  
Yuancheng Wang ◽  
Xiayong Zheng ◽  
Jian Pu ◽  
Savio L. Woo ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Vesicular Stomatitis Virus ◽  
Initial Experience ◽  
Vesicular Stomatitis

Inhibition of Various Steps in the Replication Cycle of Vesicular Stomatitis Virus Contributes to Its Photoinactivation by AlPcS4 or Pc4 and Red Light

1999 ◽  
Vol 69 (3) ◽  
pp. 353 ◽  
Author(s):  
Anne C. E. Moor ◽  
Angeline E. Wagenaars-van Gompel ◽  
Ralph C. A. Hermanns ◽  
Jannes van der Meulen ◽  
Jolanda Smit ◽  
...  
Keyword(s):  
Vesicular Stomatitis Virus ◽  
Red Light ◽  
Replication Cycle ◽  
Vesicular Stomatitis
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