scholarly journals Rapid and Successful Implementation of a COVID-19 Convalescent Plasma Programme—The South African Experience

Viruses ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2050
Author(s):  
Tanya Nadia Glatt ◽  
Caroline Hilton ◽  
Cynthia Nyoni ◽  
Avril Swarts ◽  
Ronel Swanevelder ◽  
...  
Keyword(s):  
South Africa ◽  
South African ◽  
Successful Implementation ◽  
Western Cape ◽  
The South ◽  
South Africans ◽  
African Experience ◽  
Antibody Titres ◽  
Investigational Therapies ◽  
Set Up

Background: COVID-19 convalescent plasma (CCP) has been considered internationally as a treatment option for COVID-19. CCP refers to plasma collected from donors who have recovered from and made antibodies to SARS-CoV-2. To date, convalescent plasma has not been collected in South Africa. As other investigational therapies and vaccination were not widely accessible, there was an urgent need to implement a CCP manufacture programme to service South Africans. Methods: The South African National Blood Service and the Western Cape Blood Service implemented a CCP programme that included CCP collection, processing, testing and storage. CCP units were tested for SARS-CoV-2 Spike ELISA and neutralising antibodies and routine blood transfusion parameters. CCP units from previously pregnant females were tested for anti-HLA and anti-HNA antibodies. Results: A total of 987 CCP units were collected from 243 donors, with a median of three donations per donor. Half of the CCP units had neutralising antibody titres of >1:160. One CCP unit was positive on the TPHA serology. All CCP units tested for anti-HLA antibodies were positive. Conclusion: Within three months of the first COVID-19 diagnosis in South Africa, a fully operational CCP programme was set up across South Africa. The infrastructure and skills implemented will likely benefit South Africans in this and future pandemics.

The impact of climate temperature on counts, recovery, and death rates due to SARS-CoV-2 in South Africa. (Preprint)

2020 ◽  
Author(s):  
Neven Chetty ◽  
Bamise Adeleye ◽  
Abiola Olawale Ilori
Keyword(s):  
South Africa ◽  
South African ◽  
Death Rate ◽  
Western Cape ◽  
Warm Climate ◽  
The South ◽  
Recovery Rates ◽  
Death Rates ◽  
Online Resource ◽  
The Impact

BACKGROUND The impact of climate temperature on the counts (number of positive COVID-19 cases reported), recovery, and death rates of COVID-19 cases in South Africa's nine provinces was investigated. The data for confirmed cases of COVID-19 were collected for March 25 and June 30, 2020 (14 weeks) from South Africa's Government COVID-19 online resource, while the daily provincial climate temperatures were collected from the website of the South African Weather Service. Our result indicates that a higher or lower climate temperature does not prevent or delay the spread and death rates but shows significant positive impacts on the recovery rates of COVID-19 patients. Thus, it indicates that the climate temperature is unlikely to impose a strict limit on the spread of COVID-19. There is no correlation between the cases and death rates, an indicator that no particular temperature range is closely associated with a faster or slower death rate of COVID-19 patients. As evidence from our study, a warm climate temperature can only increase the recovery rate of COVID-19 patients, ultimately impacting the death and active case rates and freeing up resources quicker to enable health facilities to deal with those patients' climbing rates who need treatment. OBJECTIVE This study aims to investigate the impact of climate temperature variation on the counts, recovery, and death rates of COVID-19 cases in all South Africa's provinces. The findings were compared with those of countries with comparable climate temperature values. METHODS The data for confirmed cases of COVID-19 were collected for March 25 and June 30 (14 weeks) for South African provinces, including daily counts, death, and recovery rates. The dates were grouped into two, wherein weeks 1-5 represent the periods of total lockdown to contain the spread of COVID-19 in South Africa. Weeks 6-14 are periods where the lockdown was eased to various levels 4 and 3. The daily information of COVID-19 count, death, and recovery was obtained from South Africa's Government COVID-19 online resource (https://sacoronavirus.co.za). Daily provincial climate temperatures were collected from the website of the South African Weather Service (https://www.weathersa.co.za). The provinces of South Africa are Eastern Cape, Western Cape, Northern Cape, Limpopo, Northwest, Mpumalanga, Free State, KwaZulu-Natal, Western Cape, and Gauteng. Weekly consideration was given to the daily climate temperature (average minimum and maximum). The recorded values were considered, respectively, to be in the ratio of death-to-count (D/C) and recovery-to-count (R/C). Descriptive statistics were performed for all the data collected for this study. The analyses were performed using the Person’s bivariate correlation to analyze the association between climate temperature, death-to-count, and recovery-to-count ratios of COVID-19. RESULTS The results showed that higher climate temperatures aren't essential to avoid the COVID-19 from being spread. The present results conform to the reports that suggested that COVID-19 is unlike the seasonal flu, which does dissipate as the climate temperature rises [17]. Accordingly, the ratio of counts and death-to-count cannot be concluded to be influenced by variations in the climate temperatures within the study areas. CONCLUSIONS The study investigates the impact of climate temperature on the counts, recovery, and death rates of COVID-19 cases in all South Africa's provinces. The findings were compared with those of countries with comparable climate temperatures as South Africa. Our result indicates that a higher or lower climate temperature does not prevent or delay the spread and death rates but shows significant positive impacts on the recovery rates of COVID-19 patients. Warm climate temperatures seem not to restrict the spread of the COVID-19 as the count rate was substantial at every climate temperatures. Thus, it indicates that the climate temperature is unlikely to impose a strict limit on the spread of COVID-19. There is no correlation between the cases and death rates, an indicator that there is no particular temperature range of the climatic conditions closely associated with a faster or slower death rate of COVID-19 patients. However, other shortcomings in this study's process should not be ignored. Some other factors may have contributed to recovery rates, such as the South African government's timely intervention to announce a national lockout at the early stage of the outbreak, the availability of intensive medical care, and social distancing effects. Nevertheless, this study shows that a warm climate temperature can only help COVID-19 patients recover more quickly, thereby having huge impacts on the death and active case rates.

scholarly journals First Report of Leaf Rust of Blueberry Caused by Thekopsora minima on Vaccinium corymbosum in the Western Cape, South Africa

Plant Disease ◽  
2010 ◽  
Vol 94 (4) ◽  
pp. 478-478 ◽  
Author(s):  
L. Mostert ◽  
W. Bester ◽  
T. Jensen ◽  
S. Coertze ◽  
A. van Hoorn ◽  
...  
Keyword(s):  
South Africa ◽  
South African ◽  
Water Solution ◽  
Phylogenetic Analyses ◽  
The United States ◽  
Vaccinium Corymbosum ◽  
Tween 20 ◽  
Western Cape ◽  
The South ◽  
First Report

Southern highbush blueberry plants (Vaccinium corymbosum interspecific hybrids) showing rust-like symptoms were observed in July 2006 in Porterville in the Western Cape (WC), South Africa. Diseased plants were also found in Villiersdorp and George in the WC in 2007. In 2008, symptoms were observed in George, and in 2009, in all the previous reported areas. Cvs. Bluecrisp, Emerald, Jewel, Sharpblue, and Star were infected. Reddish-to-brown spots appeared on the adaxial surface of leaves and developed into yellow-to-orange erumpent uredinia with pulverulent urediniospores. Uredinia were hypophyllous, dome shaped, 113 to 750 μm wide, and occasionally coalescing. Urediniospores were broadly obovate, sometimes ellipsoidal or pyriform, with yellowish orange content, and measured 19 to 27 × 12 to 20 μm (average 24 × 15 μm, n = 30). Spore walls were echinulate, hyaline, 1 to 1.5 μm thick, and with obscure germ pores. No telia or teliospores were observed. Voucher specimens were lodged in the South African National Fungus Collection in Pretoria (PREM 60245). The isolate was initially identified as Thekopsora minima P. Syd. & Syd., based primarily on the absence of conspicuous ostiolar cells characteristic of Naohidemyces spp. (3). Genomic DNA was extracted from urediniospores. Approximately 1,400 bp were amplified spanning the 5.8S, ITS2, and 28S large subunit of the ribosomal DNA (1). The sequence (GU355675) shared 96% (907 of 942 bp; GenBank AF522180) and 94% (1,014 of 1,047 bp; GenBank DQ354563) similarities in the 28S portion, respectively, to those of Naohidemyces vaccinii (Wint.) Sato, Katsuya et Y. Hiratsuka and Pucciniastrum geoppertianum (Kuehn) Kleb, two of the three known rust species of blueberry (2). Although no sequences of T. minima were available for direct comparison, phylogenetic analyses of the 28S region strongly supported the South African blueberry rust as congeneric with T. guttata (J. Schröt.) P. Syd. & Syd. (GenBank AF426231) and T. symphyti (Bubák) Berndt (GenBank AF26230) (data not shown). Four 6-month-old cv. Sharpblue plants were inoculated with a suspension (approximate final concentration of 1 × 105 spores per ml) of fresh urediniospores in a water solution with 0.05% Tween 20. After incubation at 20°C for 48 h under continuous fluorescent lighting, the plants were grown in a glasshouse (18/25°C night/day temperatures). Identical uredinia and symptoms developed approximately 3 weeks after inoculation on the inoculated plants, but not on two control plants of cv. Sharpblue sprayed with distilled water and kept at the same conditions. The alternate host hemlock (Tsuga spp.) is not endemic to South Africa and not sold as an ornamental plant according to a large conifer nursery. Hosts of T. minima include Gaylussacia baccata, G. frondosa, Lyonia neziki, Menziesia pilosa, Rhododendron canadense, R. canescens, R. lutescens R. ponticum, R. prunifolium, R. viscosum, V. angustifolium var. laevifolium, V. corumbosum, and V. erythrocarpon (3). Visual inspection of possible hosts in the gardens in close proximity of Vaccinium production areas did not show any rust symptoms. To our knowledge, this is the first report of T. minima on blueberries outside of Asia and the United States (2). References: (1) M. C. Aime. Mycoscience 47:112, 2006. (2) D. F. Farr and A. Y. Rossman. Fungal Databases. Systematic Botany and Mycology Laboratory. Online publication. USDA-ARS, 2009. (3) S. Sato et al. Trans. Mycol. Soc. Jpn. 34:47, 1993.

South Africa and Scotland in the First World War

2016 ◽  
Author(s):  
Jonathan Hyslop
Keyword(s):  
South Africa ◽  
South African ◽  
British Empire ◽  
The South ◽  
Political Identities ◽  
South Africans ◽  
The First World War ◽  
Battle Of The Somme ◽  
First World

This chapter discusses the powerful and long-lasting impact Scottish military symbolism on the formation of military culture in South Africa. Drawing on the work of John MacKenzie and Jonathan Hyslop’s notion of ‘military Scottishness’, this chapter analyses how Scottish identity both interacted with the formation of political identities in South Africa, and ‘looped back’ to connect with changing forms of national identity in Scotland itself. In particular, it addresses how the South Africans’ heroic role at Delville Wood, during the Battle of the Somme, became a putative symbol of this racialised ‘South Africanism’. The South African Brigade included a battalion of so-called ‘South African Scottish’ which reflected the phenomenon of military Scottishness. Overall, the chapter looks at the way in which the representations of the role of the South African troops involved an interplay between British empire loyalism, white South African political identities, and Scottishness.

Administrative Justice in Kenya: Learning from South Africa's Mistakes

2018 ◽  
Vol 62 (1) ◽  
pp. 105-128
Author(s):  
Cora Hoexter
Keyword(s):  
South Africa ◽  
South African ◽  
Constitutional Rights ◽  
The South ◽  
Administrative Action ◽  
African Experience ◽  
Administrative Justice

AbstractThe wording of article 47 of Kenya's Constitution of 2010 is almost identical to that of the section 33 rights to just administrative action in South Africa's 1996 Constitution. Like section 33, article 47 mandates the enactment of legislation to give effect to these constitutional rights, and Kenya's Fair Administrative Action Act 4 of 2015 was strongly influenced by the equivalent South African legislation, the Promotion of Administrative Justice Act 3 of 2000 (PAJA). South Africa can thus be regarded as a sort of laboratory for Kenyan administrative justice. The aim of this article is to highlight some of the South African experience in relation to section 33 and the PAJA in the hope that Kenya will learn from some of South Africa's mistakes. It argues that the Kenyan courts should avoid following the example of their South African counterparts in allowing their mandated legislation to become almost redundant.

Intermediaries for Child Witnesses: Old Problems, New Solutions and Judicial Differences in South Africa

2011 ◽  
Vol 19 (2) ◽  
pp. 251-269 ◽  
Author(s):  
F. Noel Zaal ◽  
Carmel R. Matthias
Keyword(s):  
South Africa ◽  
South African ◽  
International Standards ◽  
Child Witnesses ◽  
Constitutional Court ◽  
The South ◽  
Criminal Proceedings ◽  
High Court ◽  
African Experience ◽  
Implementation Problems

AbstractSouth Africa has utilised intermediaries to protect child witnesses and assist their communication in criminal proceedings in the magistrates' courts since 1993. is article examines some lessons to be learned from the South African experience. It provides an overview and assessment of attempts to overcome implementation problems and develop the legislation providing for intermediaries. It reviews contradictory solutions for improvement of the law recently put forward by the high court and constitutional court. Applying both the South African history and international standards, we argue that the high court offered a better way forward. We suggest some additional reforms which may also be relevant for advocates of the intermediary system in other jurisdictions.

scholarly journals From apartheid to Post-Apartheid: The Representational Trajectory to a Multiracial Nation in Nadine Gordimer’s None to Accompany Me, Andre Brink’s The Rights of Desire and Zakes Mda’s The Madonna of Excelsior

2021 ◽  
Vol 8 (5) ◽  
pp. 707-724
Author(s):  
FORTI ETIENNE LANGMIA
Keyword(s):  
South Africa ◽  
South African ◽  
Black Population ◽  
Nadine Gordimer ◽  
South Africans ◽  
African Experience ◽  
Andre Brink ◽  
New Nation ◽  
Zakes Mda ◽  
African Writers

This article, which draws inspiration from the literary works of three South African writers, focuses on the two (amongst many) major historic periods in the life of the present-day nation described as post-apartheid South Africa. The two periods, evident in the works of Andre Brink, Zakes Mda and Nadine Gordimer under review, are the reign of apartheid and the transition to a democratic multiracial society built on the principles of equality and the respect of the rights and freedoms of South Africans.  From both historical and literary standpoints, the transition to multiracialism is the outcome of the struggle of the oppressed black population of South Africa against the oppressive monolithic racist regime which ruled the country on an official governance policy which it called ‘Apartheid’. In order to enforce this inhumane worldview, the said racist regime used means of brutality and savagery with the intention of transforming the country into a ‘white nation’ that would belong to a minority-turned majority known as the Afrikaners. The often callous and gruesome acts of inhumanity perpetrated by the different racist apartheid regimes (that ruled South Africa from 1948-1994) became a major concern to the world at large and South African anti-apartheid writers in particular.  Thus this category of the country’s writers tended to use literature as an instrument of protest against racial discrimination, which brought untold hardship to the black population. Andre Brink, Zakes Mda, and Nadine Gordimer are among the writers whose works vividly trace the South African experience from apartheid to post-apartheid eras. Brink, Mda and Gordimer in their respective works attempt to portray the endeavours and challenges of reconstructing the new nation from the debris of close to four decades of the brutal regime. The main issues discussed in this article are analyzed from New Historicist and Postcolonial perspectives due to the peculiar postcolonial nature of South Africa.

scholarly journals From South Africa to Sri Lanka: Prospects of Travel for ‘Transformative Constitutionalism’

2020 ◽  
Vol 15 (1) ◽  
pp. 45-68
Author(s):  
Dinesha SAMARARATNE
Keyword(s):  
South Africa ◽  
South African ◽  
Transitional Justice ◽  
Institutional Design ◽  
Constitutional Reform ◽  
The South ◽  
African Experience ◽  
Comparative Constitutional Law ◽  
Layered Approach ◽  
Post War

AbstractWhat lessons can we learn from the way in which the South African experience of transformative constitutionalism was invoked in Sri Lanka's recent constitutional reform experience? What conditions allow experiences of transformative constitutionalism to travel? In this article, I respond to these two questions, using Frankenberg's idea of a ‘layered approach’ in comparative constitutional law. My analysis affirms that in the comparative enterprise, a thick explanation that allows each experience to ‘speak for itself’ heightens the value of a comparative example. In the case of South Africa, I demonstrate that transformative constitutionalism is in fact a specific genre of constitutionalism. It demands attention not only to substantive constitutional guarantees and institutional design, but also to the process of constitutional reform. Moreover, effective measures for transitional justice are an essential component of transformative constitutionalism. A closer reading of the South African experience that paid attention to these factors would have led to better use of this experience in Sri Lanka's post-war constitutional governance.

Maireana brevifolia (Chenopodiaceae: Camphorosmeae), a new naturalized alien plant species in South Africa

Bothalia ◽  
2011 ◽  
Vol 41 (2) ◽  
pp. 235-238 ◽  
Author(s):  
L. Mucina ◽  
D. A. Snijman
Keyword(s):  
South Africa ◽  
Alien Species ◽  
South African ◽  
Plant Species ◽  
Western Cape ◽  
Alien Plant Species ◽  
The South ◽  
Alien Plant ◽  
African Flora

We describe and discuss the distribution of a new, naturalized alien species, Maireana brevifolia (R.Br.) Paul G.Wilson (Chenopodiaceae), a native of Australia, in the western regions of South Africa. First discovered near Worcester, Western Cape in 1976, the species is now established in disturbed karoo shrubby rangelands, along dirt roads and on saline alluvia, from northern Namaqualand to the western Little Karoo. In the South African flora, M. brevifolia is most easily confused with the indigenous Bassia salsoloides (Fenzl) A.J.Scott, from which it is distinguished by the flat to cup-shaped and almost glabrous perianth with woolly-ciliate lobes, and the hardened and winged fruiting perianth.

scholarly journals Unequal contribution of native South African phylogeographic lineages to the invasion of the African clawed frog,Xenopus laevis, in Europe

PeerJ ◽  
2016 ◽  
Vol 4 ◽  
pp. e1659 ◽  
Author(s):  
Charlotte De Busschere ◽  
Julien Courant ◽  
Anthony Herrel ◽  
Rui Rebelo ◽  
Dennis Rödder ◽  
...  
Keyword(s):  
South Africa ◽  
Xenopus Laevis ◽  
South African ◽  
Nuclear Dna ◽  
Phylogeographic Structure ◽  
Western Cape ◽  
The South ◽  
African Clawed Frog ◽  
Northern Regions ◽  
Clawed Frog

Due to both deliberate and accidental introductions, invasive African Clawed Frog (Xenopus laevis) populations have become established worldwide. In this study, we investigate the geographic origins of invasiveX. laevispopulations in France and Portugal using the phylogeographic structure ofX. laevisin its native South African range. In total, 80 individuals from the whole area known to be invaded in France and Portugal were analysed for two mitochondrial and three nuclear genes, allowing a comparison with 185 specimens from the native range. Our results show that native phylogeographic lineages have contributed differently to invasive EuropeanX. laevispopulations. In Portugal, genetic and historical data suggest a single colonization event involving a small number of individuals from the south-western Cape region in South Africa. In contrast, French invasiveX. laevisencompass two distinct native phylogeographic lineages, i.e., one from the south-western Cape region and one from the northern regions of South Africa. The FrenchX. laevispopulation is the first example of aX. laevisinvasion involving multiple lineages. Moreover, the lack of population structure based on nuclear DNA suggests a potential role for admixture within the invasive French population.

Sign in / Sign up

Export Citation Format

Share Document