scholarly journals Animal Coronavirus Diseases: Parallels with COVID-19 in Humans

Viruses ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1507
Author(s):  
Chao-Nan Lin ◽  
Kuan Rong Chan ◽  
Eng Eong Ooi ◽  
Ming-Tang Chiou ◽  
Minh Hoang ◽  
...  
Keyword(s):  
Genome Organization ◽  
Clinical Signs ◽  
Feline Infectious Peritonitis ◽  
Viral Shedding ◽  
Related Disease ◽  
The Past ◽  
Treatment And Prevention ◽  
Historical Archives ◽  
Huge Impact ◽  
Novel Coronavirus

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus in humans, has expanded globally over the past year. COVID-19 remains an important subject of intensive research owing to its huge impact on economic and public health globally. Based on historical archives, the first coronavirus-related disease recorded was possibly animal-related, a case of feline infectious peritonitis described as early as 1912. Despite over a century of documented coronaviruses in animals, the global animal industry still suffers from outbreaks. Knowledge and experience handling animal coronaviruses provide a valuable tool to complement our understanding of the ongoing COVID-19 pandemic. In this review, we present an overview of coronaviruses, clinical signs, COVID-19 in animals, genome organization and recombination, immunopathogenesis, transmission, viral shedding, diagnosis, treatment, and prevention. By drawing parallels between COVID-19 in animals and humans, we provide perspectives on the pathophysiological mechanisms by which coronaviruses cause diseases in both animals and humans, providing a critical basis for the development of effective vaccines and therapeutics against these deadly viruses.

scholarly journals The Novel Coronavirus (nCoV) – A Worldwide Threat

2020 ◽  
pp. 1-4
Author(s):  
Július Rajčáni ◽  
Keyword(s):  
Clinical Signs ◽  
Epidemiological Data ◽  
Pathological State ◽  
The Novel ◽  
Information Selection ◽  
Related Disease ◽  
Actual Nature ◽  
Virion Structure ◽  
Novel Coronavirus ◽  
The Given

This review aims to asses the data from recently published literature related to the novel Coronavirus (nCoV), which had been isolated in the automn of 2019. Similarly to the classical Coronavirus (cCoV) isolated nearly 18 years ago, the nCoV has also emerged in China, though in a different region of the same country. The majority of papers published in the current year 2020, clearly demonstrates the actual nature of the given topics. Despite of the unusual criteria used for information selection, all the collected data have turned up useful as the virion structure and its properties concerns. Neither were omitted the clinical signs of virus related disease(s) nor understanding the spread of any other pathological state(s) occurring in infected patients. Last but not least, the presented epidemiological data contribute to understanding the spread of nCoV in human community(ies).

scholarly journals Detection and semi-quantification of antibodies to the feline infectious peritonitis virus in cats from the Ilhéus-Itabuna microregion, Bahia, Brazil

2021 ◽  
Vol 42 (2) ◽  
pp. 747-756
Author(s):  
Jéssica Fontes Veloso ◽  
◽  
Leonardo Sauer ◽  
Lohana Mehnati Costa e Silva ◽  
Samantha Gusmão Pellizzoni ◽  
...  
Keyword(s):  
Complete Blood Count ◽  
Fluorescent Antibody ◽  
Clinical Signs ◽  
Antibody Test ◽  
State University ◽  
Biochemical Tests ◽  
Feline Infectious Peritonitis ◽  
Worldwide Distribution ◽  
Novel Coronavirus ◽  
Veterinary Hospital

Feline coronavirus (FCoV) is an important virus that can be differentiated into two serotypes: feline enteric coronavirus (FECoV) and feline infectious peritonitis (FIP) virus (FIPV). Researchers have suggested that a mutation of FECoV to FIPV leads to the emergence of FIP, a disease with worldwide distribution and a high mortality rate. Furthermore, in December 2019, a human infectious disease, coronavirus disease-2019 (COVID-19), which is also caused by a coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) emerged, and clarity regarding its relationship with FCoV remains lacking. Studies have shown that cats are susceptible to infection with this novel coronavirus (i.e., SARS-CoV-2). The aim of the present study was to detect and semi-quantify the presence of feline antibodies to FIPV in cats examined at the Veterinary Hospital of Santa Cruz State University, microregion of Ilhéus and Itabuna, Bahia, Brazil, between January and April 2018. Blood samples were collected from 68 domestic cats to perform complete blood count (CBC) and biochemical tests, and an indirect fluorescent antibody test (IFAT) was used to detect FCoV infection. Of the 68 samples evaluated, seropositivity was observed in 4.4% (3/68) at titers of 1:20; only one sample remained seropositive at titers of 1:40 and 1:80. Two positive animals exhibited CBC and biochemical values within the normal range, while the other positive animals exhibited a mild decrease in platelet count (173,000 uL-1), mild lymphocytosis (7395 uL-1), and mildly increased alkaline phosphatase level (134 uL-1). Twelve months after the tests, none of the positive animals exhibited clinical signs consistent with FIP. Although the IFAT can facilitate diagnosis of FPIV, it cannot be used to differentiate antibodies for the FECoV and FIPV serotypes. Results of the present study demonstrated that FCoV was present in the population studied, and is an important risk factor for the development of FIP. In addition, the new COVID-19 pandemic highlights the importance of studies investigating FCoV because it was not possible to rule out, until now, the possibility of FCoV mutations in infected cats if it encounters SARS-CoV-2.

scholarly journals Exercise-induced pulmonary haemorrhage in horses – review

2013 ◽  
Vol 82 (3) ◽  
pp. 309-316
Author(s):  
Gabriel Morán ◽  
Hugo Folch
Keyword(s):  
Clinical Signs ◽  
Poor Performance ◽  
Pulmonary Haemorrhage ◽  
Exercise Intolerance ◽  
Strenuous Exercise ◽  
The Past ◽  
Treatment And Prevention ◽  
Pulmonary Capillaries ◽  
Considerable Debate ◽  
Exercise Induced

Exercise-induced pulmonary haemorrhage is a major cause of poor performance in the equine athlete. It is an important cause of exercise intolerance and results from strenuous exercise and pathophysiological changes in the equine lung and possibly in the airways. Endoscopic surveys of the respiratory tracts of horses after competitive events have shown that many horses experience exercise-induced pulmonary haemorrhage. The reported incidence of exercise-induced pulmonary haemorrhage in different breeds varies between 40–85%. The cause of bleeding in exercising horses has fostered considerable debate over the past three centuries, but currently, the most accepted hypothesis is that the source of haemorrhage is disruption of the pulmonary capillaries during exercise. Furosemide is the medication used most widely for the treatment and prevention of exercise-induced pulmonary haemorrhage. This review provides an update on the aetiology, clinical signs, physiopathology, diagnosis and treatment of exercise-induced pulmonary haemorrhage.

Review on Efficacy of Herbal Antiviral Drugs against COVID-19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1116-1121
Author(s):  
Pooja P. Thakre ◽  
Vinod Ade ◽  
Shweta Parwe
Keyword(s):  
Physical Contact ◽  
Research Articles ◽  
Herbal Drugs ◽  
Plant Origin ◽  
Respiratory Pathway ◽  
Traditional Medicines ◽  
The Past ◽  
Primary Health ◽  
Coronavirus Infection ◽  
Novel Coronavirus

Coronavirus disease (CoViD-19) is an infection of the respiratory system caused due to various viruses affects the respiratory pathway, and it can spread from one person to another by coughing, sneezing or physical contact. Commonly include cough, cold, fever are the symptoms. Viral diseases increase worldwide concern, including emerging and chronic viruses. The invention of new anti-viral drugs from plants has implicit in the past. The Coronavirus disease 19 (COVID-19) caused due to severe acute respiratory syndrome, which is a transmittable and pathogenic viral infection. Several traditional medicines of plant origin having antimicrobial and anti-inflammatory properties some have been studied for their anti-viral properties and immune-modulating effects. Herbal drugs are now in massive requirement in the developing countries for primary health care not because of their economical but also for better civilising adequacy, improved compatibility with the human body and significantly fewer side effects. This review gives an overview of some critical traditionally used medicinal herbs with anti-viral properties—the literature regarding the drugs of this group, collected from Ayurveda classics. Research articles are collected from published material and discussed per therapeutic actions. Most of the Herbs are with Katu Rasa (pungent) and Ushna Virya (hot potency). They are indicated in diseases, viz. Kasa (cough), Shwas (asthma), Krumi (worm/ infection). Krumihara property drugs which are correlated with anti-viral action helps to prevent against Novel coronavirus infection.

Novel Coronavirus Disease (COVID-19): A Narrative Review Based on Current Status

2020 ◽  
Vol 18 ◽  
Author(s):  
Rina Das ◽  
Dinesh Kumar Mehta ◽  
Meenakshi Dhanawat
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Clinical Symptoms ◽  
Virus Disease ◽  
Relevant Literature ◽  
World Health ◽  
Current Status ◽  
Future Research ◽  
Treatment And Prevention ◽  
First Case ◽  
Novel Coronavirus

Abstract:: A novel virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), appeared and expanded globally by the end of year in 2019 from Wuhan, China, causing severe acute respiratory syndrome. During its initial stage, the disease was called the novel coronavirus (2019-nCoV). It was named COVID-19 by the World Health Organization (WHO) on 11 February 2020. The WHO declared worldwide the SARS-CoV-2 virus a pandemic on March 2020. On 30 January 2020 the first case of Corona Virus Disease 2019 (COVID-19) was reported in India. Now in current situation the virus is floating in almost every part of the province and rest of the globe. -: On the basis of novel published evidences, we efficiently summarized the reported work with reference to COVID-19 epidemiology, pathogen, clinical symptoms, treatment and prevention. Using several worldwide electronic scientific databases such as Pubmed, Medline, Embase, Science direct, Scopus, etc were utilized for extensive investigation of relevant literature. -: This review is written in the hope of encouraging the people successfully with the key learning points from the underway efforts to perceive and manage SARS-CoV-2, suggesting sailent points for expanding future research.

scholarly journals SARS-CoV-2/DENV co-infection: a series of cases from the Federal District, Midwestern Brazil

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Heidi Luise Schulte ◽  
José Diego Brito-Sousa ◽  
Marcus Vinicius Guimarães Lacerda ◽  
Luciana Ansaneli Naves ◽  
Eliana Teles de Gois ◽  
...  
Keyword(s):  
Clinical Signs ◽  
Federal District ◽  
Therapeutic Interventions ◽  
Diagnostic Process ◽  
The Novel ◽  
Prevention Measures ◽  
Laboratory Findings ◽  
Novel Coronavirus ◽  
The Impact

Abstract Background Since the novel coronavirus disease outbreak, over 179.7 million people have been infected by SARS-CoV-2 worldwide, including the population living in dengue-endemic regions, particularly Latin America and Southeast Asia, raising concern about the impact of possible co-infections. Methods Thirteen SARS-CoV-2/DENV co-infection cases reported in Midwestern Brazil between April and September of 2020 are described. Information was gathered from hospital medical records regarding the most relevant clinical and laboratory findings, diagnostic process, therapeutic interventions, together with clinician-assessed outcomes and follow-up. Results Of the 13 cases, seven patients presented Acute Undifferentiated Febrile Syndrome and six had pre-existing co-morbidities, such as diabetes, hypertension and hypopituitarism. Two patients were pregnant. The most common symptoms and clinical signs reported at first evaluation were myalgia, fever and dyspnea. In six cases, the initial diagnosis was dengue fever, which delayed the diagnosis of concomitant infections. The most frequently applied therapeutic interventions were antibiotics and analgesics. In total, four patients were hospitalized. None of them were transferred to the intensive care unit or died. Clinical improvement was verified in all patients after a maximum of 21 days. Conclusions The cases reported here highlight the challenges in differential diagnosis and the importance of considering concomitant infections, especially to improve clinical management and possible prevention measures. Failure to consider a SARS-CoV-2/DENV co-infection may impact both individual and community levels, especially in endemic areas.

Children have type 2 diabetes too: an historical perspective

2015 ◽  
Vol 93 (5) ◽  
pp. 425-429 ◽  
Author(s):  
Heather J. Dean ◽  
Elizabeth A.C. Sellers
Keyword(s):  
Type 2 Diabetes ◽  
Case Series ◽  
Indigenous Populations ◽  
Long Term Outcomes ◽  
Global Epidemic ◽  
The Past ◽  
Treatment And Prevention ◽  
End Stage

Prior to 1985, type 2 diabetes was a disease of adults. Simultaneously with the global epidemic of childhood obesity, type 2 diabetes has increased in children. Initially, the presentation of small case series of type 2 diabetes in children was met with skepticism. As the number and size of the case series grew and the first long-term outcomes of end-stage complications in young adults appeared in the literature, the international community took notice with guarded interest. Type 2 diabetes disproportionately affects the children of specific ethnic groups and from disadvantaged socioeconomic environments, especially Indigenous populations. The past decade has seen unprecedented intense global interest in the etiology, treatment, and prevention of type 2 diabetes in children.

The roles of vitamin D in increasing the body's immunity and reducing injuries due to viral infections: With an emphasis on its possible role in SARS-CoV-2 (COVID-19)

2021 ◽  
Vol 27 ◽  
Author(s):  
Elahe Aleebrahim-Dehkordi ◽  
Niloofar Deravi ◽  
Shirin Yaghoobpoor ◽  
Dariush Hooshyar ◽  
Mahmoud Rafieian-Kopaei
Keyword(s):  
Vitamin D ◽  
Immune System ◽  
Vitamin D Deficiency ◽  
Viral Infections ◽  
Vitamin D Supplementation ◽  
Angiotensin Converting Enzyme 2 ◽  
Treatment And Prevention ◽  
Lung Injuries ◽  
Novel Coronavirus ◽  
Cytochrome P450 Family

Background: It is known that Vitamin D can increase the body’s immunity against some viral infections. Many people around the world have vitamin D deficiency and, therefore, this has become a public concern whether vitamin D is an important factor protecting against COVID-19 infection. In this paper, the data about the roles of vitamin D on immunity and recovery from viral infections, especially novel Coronavirus disease (COVID-19) is reviewed. Methods: The electronic databases of Pubmed, Google Scholar, Research Gate, Excerpta Media Database (EMBASE) and Medical and Health Education (Medrix) were searched. Results: Vitamin D is considered an important factor in immune homeostasis. Various effects have been considered for this nutrient on the immune system, particularly because of vitamin D receptor (VDR) and Cytochrome P450 Family 27 Subfamily B Member 1 (CYP27B1) expression in most of the immune cells. Vitamin D can raise cellular immunity, reduce cytokine storm and enhance antioxidants production. It also has modulatory effects on Angiotensin-converting enzyme 2 (ACE2) receptors and might have protective functions against acute lung injuries, including COVID-19 infection. However, there are some articles against this positive effect. Conclusion: Vitamin D supplementation is reported to be effective in the enhancement of the immune system and might be effective in the treatment and prevention of COVID-19 infection, especially in those with its deficiency. However, it should be considered that vitamin D deficiency shows the overall health status of the patients and cannot be considered specific for COVID-19 infection.

Children With Influenza A Infection: Treatment With Rimantadine

PEDIATRICS ◽  
1987 ◽  
Vol 80 (2) ◽  
pp. 275-282
Author(s):  
Caroline Breese Hall ◽  
Raphael Dolin ◽  
Christine L. Gala ◽  
David M. Markovitz ◽  
Yu Qin Zhang ◽  
...  
Keyword(s):  
Influenza A ◽  
Clinical Signs ◽  
Severity Of Illness ◽  
Signs And Symptoms ◽  
Clinical Isolates ◽  
Double Blind Study ◽  
Double Blind ◽  
Viral Shedding ◽  
Development Of Resistance ◽  
Clinical Signs And Symptoms

Treatment with rimantadine of influenza in children and the potential development of resistance in clinical isolates associated with therapy have not been previously studied. We compared rimantadine to acetaminophen therapy in a controlled, double-blind study of 91 children with influenza-like illness. Of 69 children with proven influenza A/H3N2 infection, 37 received rimantadine and 32 received acetaminophen for five days. Children receiving rimantadine showed significantly greater reduction in fever and improvement in daily scores for symptoms and severity of illness during the first three days. Viral shedding also diminished significantly during the first two days but subsequently increased such that by days 6 and 7 the proportion of children shedding virus, as well as the quantity of virus shed, was significantly greater in the rimantadine group. During the seven-day study, of the 22 children in the rimantadine group with serial isolates tested, ten (45.5%) had resistant isolates compared with two (12.5%) of those with serial isolates in the acetaminophen group (P < .03). Thus, of the total 37 children in the rimantadine group, 27% were found to have resistant isolated compared with 6% in the total group receiving acetaminophen (P < .04). Furthermore, the mean inhibitory concentration of rimantadine increased with time in the rimantadine group (r = .4, P = .002) but not in the acetaminophen group. Rimantadine therapy, thus, appears to be significantly more effective than acetaminophen in ameliorating the clinical signs and symptoms of influenza in children. Treatment with rimantadine was also associated with increased viral shedding after the medication was discontinued and with the development of resistance in the clinical isolates, the significance of which is unknown.

Impact of COVID-19 CORONAVIRUS PANDEMIC on sustainable development goals: What we learn from the past and where we are heading?

2020 ◽  
Vol 1 (1) ◽  
pp. 30-47
Author(s):  
Muhammad Imran Qureshi ◽  
Nohman Khan
Keyword(s):  
Literature Review ◽  
Systematic Literature Review ◽  
Economic Recession ◽  
Historical Background ◽  
Screening Process ◽  
Infected People ◽  
The Past ◽  
Development Goals ◽  
Novel Coronavirus ◽  
Human Infections

The recent deadly outbreak of Novel Coronavirus (2019-COVID) accompanying human to human spread caused severe human infections.  COVID19 initially encountered at the city of Wuhan in Hubei province in China.  It spread rapidly, and the number of infected people, as well as fatality ratio, increased drastically around the globe. This study aims to identify the historical background of the coronavirus family that is already affected the civilization and animals. This study overviewed the overall literature published on the Coronavirus. The Scopus database is selected to analyse the published literature. The research methodology followed a strict screening process recommended in the PRISMA statement framework (2015) for the screening and quality assessment of systematic literature review. Final 41 studies were included for the systematic literature review. A systematic review of the past literature identified severe acute respiratory syndrome coronavirus (SARS), Middle East Respiratory Syndrome Coronavirus (MERS), bovine Coronavirus, canine Coronavirus and feline Coronavirus are the significant classifications of Coronavirus family discuss in the literature. This study contributes to the literature by providing an elaboration of detailed mapping of the existing literature on the reviews of Coronavirus pandemic that is a more significant challenge for humanity in the current circumstances. Finally, the future of the world after the 2019-COVID is more challenging and vital for understanding in terms of economic and social perspective. Social structures will change the current situation is showing based on literature and reports. The economic recession will be prolonged if the researchers are not able to find the solution for the Coronavirus.

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