Children have type 2 diabetes too: an historical perspective

2015 ◽  
Vol 93 (5) ◽  
pp. 425-429 ◽  
Author(s):  
Heather J. Dean ◽  
Elizabeth A.C. Sellers
Keyword(s):  
Type 2 Diabetes ◽  
Case Series ◽  
Indigenous Populations ◽  
Long Term Outcomes ◽  
Global Epidemic ◽  
The Past ◽  
Treatment And Prevention ◽  
End Stage

Prior to 1985, type 2 diabetes was a disease of adults. Simultaneously with the global epidemic of childhood obesity, type 2 diabetes has increased in children. Initially, the presentation of small case series of type 2 diabetes in children was met with skepticism. As the number and size of the case series grew and the first long-term outcomes of end-stage complications in young adults appeared in the literature, the international community took notice with guarded interest. Type 2 diabetes disproportionately affects the children of specific ethnic groups and from disadvantaged socioeconomic environments, especially Indigenous populations. The past decade has seen unprecedented intense global interest in the etiology, treatment, and prevention of type 2 diabetes in children.

Abstract #238: Improved Short Term and Long Term Outcomes of Early Insulin Initiation in Type 2 Diabetes Over 10 Years

2017 ◽  
Vol 23 ◽  
pp. 50
Author(s):  
Jothydev Kesavadev ◽  
Shashank Joshi ◽  
Banshi Saboo ◽  
Hemant Thacker ◽  
Arun Shankar ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Initiation ◽  
Long Term Outcomes ◽  
Short Term

scholarly journals Intestinal microbiota and their metabolic contribution to type 2 diabetes and obesity

2021 ◽  
Author(s):  
A. L. Cunningham ◽  
J. W. Stephens ◽  
D. A. Harris
Keyword(s):  
Type 2 Diabetes ◽  
Gut Microbiota ◽  
Current Knowledge ◽  
Intestinal Barrier ◽  
Short Chain Fatty Acids ◽  
Global Epidemic ◽  
Technological Advances ◽  
Diabetes And Obesity

AbstractObesity and type 2 diabetes mellitus (T2DM) are common, chronic metabolic disorders with associated significant long-term health problems at global epidemic levels. It is recognised that gut microbiota play a central role in maintaining host homeostasis and through technological advances in both animal and human models it is becoming clear that gut microbiota are heavily involved in key pathophysiological roles in the aetiology and progression of both conditions. This review will focus on current knowledge regarding microbiota interactions with short chain fatty acids, the host inflammatory response, signaling pathways, integrity of the intestinal barrier, the interaction of the gut-brain axis and the subsequent impact on the metabolic health of the host.

Diet and diabetes - part 2

2007 ◽  
Vol 286 ◽  
pp. 1-3
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Control ◽  
Alcohol Intake ◽  
Dietary Advice ◽  
Lifestyle Interventions ◽  
Long Term Outcomes ◽  
Short Term ◽  
Diet And Diabetes

In a nutshellDietary advice for diabetics has included both reducing and increasing CHO.Some short term trials show improved glucose control from lower CHO, more fibre and lower GI foods. Light alcohol intake may provide some benefit. All these require further trials on their long term outcomes. And we should remember that, of all the lifestyle interventions in type 2 diabetes, the most effective appears to be exercise.

scholarly journals The Association Between Age of Onset of Type 2 Diabetes with Long-term Risk of End Stage Kidney Disease: A National Registry Study

2020 ◽  
Author(s):  
Jedidiah I Morton ◽  
Danny Liew ◽  
Stephen P McDonald ◽  
Jonathan E Shaw ◽  
Dianna J Magliano
Keyword(s):  
Type 2 Diabetes ◽  
Kidney Disease ◽  
Cumulative Incidence ◽  
Age Of Onset ◽  
End Stage Kidney Disease ◽  
Onset Of Diabetes ◽  
End Stage ◽  
Effect Of Age

<b>Objective</b>: The long-term risk of end-stage kidney disease (ESKD) in type 2 diabetes is poorly described, as is the effect that younger age of diabetes onset has on this risk. Therefore, we aimed to estimate the effect of age of onset on the cumulative incidence of ESKD from onset of type 2 diabetes. <p><b>Research Design and Methods: </b>This study included 1,113,201 people with type 2 diabetes registered on the Australian National Diabetes Services Scheme (NDSS) followed from 2002 until 2013. The NDSS was linked to the Australia and New Zealand Dialysis and Transplant Registry and the Australian National Death Index. </p> <p><b>Results: </b>Between 2002 and 2013,<b> </b>there were 7,592 incident cases of ESKD during 7,839,075 person-years of follow up. In the first 10-15 years following onset of diabetes, the incidence of ESKD was highest in those with an older age of onset of diabetes, whereas over longer durations of diabetes the incidence of ESKD became higher in those with younger-onset diabetes. After 40 years of diabetes, the cumulative incidence of ESKD was 11.8% and 9.3% in those diagnosed with diabetes aged 10-29 and 30-39 years, respectively. When death from ESKD without renal replacement therapy was included, incidence of ESKD remained higher in older onset diabetes for the initial 20 years, with no clear effect of age thereafter.</p> <p><b>Conclusions: </b>The long-term risk of ESKD in type 2 diabetes is high, which disproportionately affects those with younger-onset of diabetes as they are more likely to survive to longer diabetes durations.</p>

Long-term outcomes comparing metabolic surgery to no surgery in patients with type 2 diabetes and body mass index 30–35

2020 ◽  
Vol 16 (4) ◽  
pp. 503-508 ◽  
Author(s):  
Daniel Horwitz ◽  
Christina Padron ◽  
Timothy Kelly ◽  
John K. Saunders ◽  
Aku Ude-Welcome ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Body Mass ◽  
Metabolic Surgery ◽  
Long Term Outcomes

Therapy conversion to biphasic insulin aspart 30 improves long-term outcomes and reduces the costs of type 2 diabetes in Saudi Arabia

2008 ◽  
Vol 11 (4) ◽  
pp. 651-670 ◽  
Author(s):  
Mohammed Ali ◽  
Jeremy White ◽  
Chen-Hui Lee ◽  
James L Palmer ◽  
Jayne Smith-Palmer ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Saudi Arabia ◽  
Insulin Aspart ◽  
Long Term Outcomes ◽  
Biphasic Insulin Aspart ◽  
Biphasic Insulin ◽  
Biphasic Insulin Aspart 30

scholarly journals Long-term outcomes in patients with type 2 diabetes receiving glimepiride combined with liraglutide or rosiglitazone

2009 ◽  
Vol 8 (1) ◽  
pp. 12 ◽  
Author(s):  
Sean D Sullivan ◽  
Rafael Alfonso-Cristancho ◽  
Chris Conner ◽  
Mette Hammer ◽  
Lawrence Blonde
Keyword(s):  
Type 2 Diabetes ◽  
Long Term Outcomes

Long-term outcomes of patients with type 2 diabetes attending a multidisciplinary diabetes kidney disease clinic

2017 ◽  
Vol 10 (7) ◽  
pp. 572-580 ◽  
Author(s):  
Serena Low ◽  
Su Chi Lim ◽  
Jiexun Wang ◽  
Lee Ying Yeoh ◽  
Yan Lun Liu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Kidney Disease ◽  
Long Term Outcomes ◽  
Disease Clinic
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