scholarly journals Fatal Neonatal Sepsis Associated with Human Adenovirus Type 56 Infection: Genomic Analysis of Three Recent Cases Detected in the United States

Viruses ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1105
Author(s):  
William R. Otto ◽  
Daryl M. Lamson ◽  
Gabriel Gonzalez ◽  
Geoffrey A. Weinberg ◽  
Nicole D. Pecora ◽  
...  
Keyword(s):  
United States ◽  
Neonatal Sepsis ◽  
Fatal Case ◽  
Genomic Analysis ◽  
Human Adenovirus ◽  
Adenovirus Type ◽  
The United States ◽  
Enzyme Analysis ◽  
Restriction Enzyme Analysis ◽  
Genome Sequences

Background: Human adenovirus (HAdV)-D56 was first described in 2011 by genomics analysis of a strain isolated in France in 2008 from a fatal case of neonatal infection. Since then, it has been reported in cases of keratoconjunctivitis and male urethritis. Three epidemiologically unrelated fatal cases of neonatal sepsis associated with infection by HAdV-D strains with a similar genetic makeup were documented in the United States between 2014 and 2020. Methods: Whole genome sequences were obtained for the isolated strains, and genomics analyses were conducted to compare them to phylogenetically related HAdV-D genomic sequences available in GenBank. Results: The three new US strains were indistinguishable by in silico restriction enzyme analysis. Their genome sequences were 99.9% identical to one another and to the prototype strain isolated in 2008 from a similar context of disease. The phylogenetic reconstruction revealed a highly supported clustering of all HAdV-D56 strains isolated in various countries since 1982. Our comparison to serologically intermediate strains 15/H9 described in the literature indicated that HAdV-D56-like viruses have circulated worldwide since the late 1950s. Conclusion: As with other HAdV-D genotypes with the ability to infect ocular and genital mucosae, the risk of severe prenatal or perinatal HAdV-D56 infection must be considered.

scholarly journals Complete Genome Sequences of Two Human Adenovirus Type 55 Isolates from South Korea and the United States

2021 ◽  
Vol 10 (5) ◽  
Author(s):  
Jerry J. Hughes ◽  
Yu Yang ◽  
Anthony C. Fries ◽  
Irina Maljkovic Berry ◽  
Adam R. Pollio ◽  
...  
Keyword(s):  
United States ◽  
South Korea ◽  
Complete Genome ◽  
Human Adenovirus ◽  
Adenovirus Type ◽  
The United States ◽  
Genome Sequences

ABSTRACT Here, we report two complete genome sequences of human adenovirus 55 (HAdV-55) isolates, from a patient in Pennsylvania in 2006 and a U.S. military member in South Korea in 2019. The findings demonstrate the continued global transmission of HAdV-55 viruses in both military and civilian populations.

scholarly journals Comparative genomic analysis of two strains of human adenovirus type 3 isolated from children with acute respiratory infection in southern China

2006 ◽  
Vol 87 (6) ◽  
pp. 1531-1541 ◽  
Author(s):  
Qiwei Zhang ◽  
Xiaobo Su ◽  
Sitang Gong ◽  
Qiyi Zeng ◽  
Bing Zhu ◽  
...  
Keyword(s):  
Respiratory Infection ◽  
Acute Respiratory Infection ◽  
Southern China ◽  
Genomic Analysis ◽  
Human Adenovirus ◽  
Adenovirus Type ◽  
Comparative Genomic ◽  
Genome Sequences ◽  
Whole Genome Analysis ◽  
Type 3

Human adenovirus type 3 (HAdV-3) is a causative agent of acute respiratory disease, which is prevalent throughout the world, especially in Asia. Here, the complete genome sequences of two field strains of HAdV-3 (strains GZ1 and GZ2) isolated from children with acute respiratory infection in southern China are reported (GenBank accession nos DQ099432 and DQ105654, respectively). The genomes were 35 273 bp (GZ1) and 35 269 bp (GZ2) and both had a G+C content of 51 mol%. They shared 99 % nucleotide identity and the four early and five late regions that are characteristic of human adenoviruses. Thirty-nine protein- and two RNA-coding sequences were identified in the genome sequences of both strains. Protein pX had a predicted molecular mass of 8.3 kDa in strain GZ1; this was lower (7.6 kDa) in strain GZ2. Both strains contained 10 short inverted repeats, in addition to their inverted terminal repeats (111 bp). Comparative whole-genome analysis revealed 93 mismatches and four insertions/deletions between the two strains. Strain GZ1 infection produced a typical cytopathic effect, whereas strain GZ2 did not; non-synonymous substitutions in proteins of GZ2 may be responsible for this difference.

Molecular Epidemiology of Adenovirus Type 7 in the United States, 1966-2000

2002 ◽  
Author(s):  
Dean D. Erdman ◽  
Wanhong Xu ◽  
Susan I. Gerber ◽  
Gregory C. Gray ◽  
David Schnurr
Keyword(s):  
United States ◽  
Molecular Epidemiology ◽  
Adenovirus Type ◽  
The United States

scholarly journals Sequences of Seven Complete Genomes of Human Parvovirus B19

2018 ◽  
Vol 7 (11) ◽  
Author(s):  
Yuhuan Qiu ◽  
Zehui Zhao ◽  
Jianming Qiu
Keyword(s):  
United States ◽  
Human Plasma ◽  
Parvovirus B19 ◽  
The United States ◽  
Human Parvovirus B19 ◽  
Genome Sequences ◽  
Complete Genomes ◽  
Inverted Terminal Repeats ◽  
Terminal Repeats

We are reporting the sequences of seven complete genomes of parvovirus B19, which were extracted from human plasma specimens collected in the United States. The seven B19 genome sequences, which are 5,596 nucleotides long and include the inverted terminal repeats (ITRs), share an identity of 96.73%.

scholarly journals Heartland virus: a novel and emerging tick-borne encephalitis

2016 ◽  
pp. 5099-5101
Author(s):  
Salim Mattar V. ◽  
Marco González T.
Keyword(s):  
United States ◽  
Causative Agent ◽  
Human Disease ◽  
Fatal Case ◽  
The United States ◽  
Tick Borne Encephalitis

Heartland virus (HRTV) is a Bunyaviridae, phlebovirus that it has recently emerged as the causative agent of human disease characterized by thrombocytopenia and leukopenia in the United States and China. It seems to be the HRTV has been also reported in China, Japan and Korea. Recently the first fatal case of HRTV disease in an 80-year-old Tennessee resident was reported (1)

scholarly journals Draft Genome Sequences ofAnaplasma phagocytophilum,A. marginale, andA. ovisIsolates from Different Hosts

2018 ◽  
Vol 6 (5) ◽  
Author(s):  
Sandra Diaz-Sanchez ◽  
Angélica Hernández-Jarguín ◽  
Isabel G. Fernández de Mera ◽  
Pilar Alberdi ◽  
Erich Zweygarth ◽  
...  
Keyword(s):  
United States ◽  
Genome Sequence ◽  
Anaplasma Phagocytophilum ◽  
Draft Genome ◽  
Anaplasma Marginale ◽  
The United States ◽  
Genome Sequences ◽  
Anaplasma Ovis ◽  
First Report

ABSTRACTHere, we report the draft genome sequences of isolates ofAnaplasma phagocytophilum,Anaplasma marginale, andAnaplasma ovis. The genomes ofA. phagocytophilum(human),A. marginale(cattle), andA. ovis(goat) isolates from the United States were sequenced and characterized. This is the first report of anA. ovisgenome sequence.

scholarly journals A Fatal Case of Primary Amoebic Meningoencephalitis from Recreational Waters

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Edward Hamaty ◽  
Saif Faiek ◽  
Minesh Nandi ◽  
David Stidd ◽  
Manish Trivedi ◽  
...  
Keyword(s):  
United States ◽  
Mortality Rate ◽  
Bacterial Meningitis ◽  
Fatal Case ◽  
Altered Mental Status ◽  
The United States ◽  
Recreational Waters ◽  
Primary Amoebic Meningoencephalitis ◽  
Presenting Symptoms ◽  
Amoebic Meningoencephalitis

Background. Naegleria Fowleri is a single-cell, thermophilic amphizoid amoeba, and a rare known causative agent for primary amoebic meningoencephalitis with >97% mortality rate. The amoeba resides in freshwater lakes and ponds but can also survive in inadequately chlorinated pools and recreational waters. The mode of infection includes activities such as diving or jumping into freshwater or submerging the head under the water. Although most commonly seen in the southern United States, it is essential to keep this clinical suspicion in mind regardless of geography, as presenting symptoms can be very similar to classic bacterial meningitis. Case Summary. We report the first-ever case in the state of New Jersey of a 29-year-old male presented after a visit to a recreational water park in Texas five days before his presentation with altered mental status. In ICU, his ICP remained refractory to multiple therapies, including antibiotics and antivirals, external ventriculostomy drain, hypertonic saline, pentobarbital-induced coma, and bilateral hemicraniectomies. The CSF analysis revealed trophozoites indicating a protozoan infection, which we diagnosed in the neurocritical unit, and the patient was then immediately started with treatment that included amphotericin B, rifampin, azithromycin, and fluconazole. This suspicion was promptly confirmed by the Center for Disease Control (CDC). Unfortunately, despite all the aggressive intervention by the multidisciplinary team, the patient did not survive. Conclusion. As per the CDC, only four people out of 143 known infected individuals in the United States from 1962 to 2017 have survived. Symptoms start with a median of 5 days after exposure to contaminated water. Given the rarity of this case and its very high mortality rate, it is crucial to diagnose primary amoebic meningoencephalitis accurately as its presentation can mimic bacterial meningitis. It is vital to obtain a careful and thorough history, as it can aid in prompt diagnosis and treatment.

scholarly journals Genome Sequences of Two Bacillus Phages Isolated from Indonesia

2019 ◽  
Vol 8 (50) ◽  
Author(s):  
Yoga A. Handoko ◽  
Agustin K. Wardani ◽  
Aji Sutrisno ◽  
Simon B. Widjanarko ◽  
Trever L. Thurgood ◽  
...  
Keyword(s):  
United States ◽  
South Korea ◽  
The United States ◽  
Genome Sequences ◽  
Content Type

Here, the genome sequences of two soil bacteriophages isolated from a red chili plantation in Indonesia are presented. The genome of vB_BspS_SplendidRed (42,859 bp) is highly similar to Bacillus phage Ray17 from the United States, while vB_BspM_MarvelLand (156,945 bp) is highly similar to Bacillus phage BC01 from South Korea.

Sign in / Sign up

Export Citation Format

Share Document