scholarly journals Genetic Markers Associated with Field PRRSV-Induced Abortion Rates

Viruses ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 706 ◽  
Author(s):  
Pena ◽  
Fernández ◽  
Blasco-Felip ◽  
Fraile ◽  
Estany

In gilts and sows, the more severe clinical manifestation of porcine reproductive and respiratory syndrome virus (PRRSV) occurs in late gestation and can result in up to a 40% abortion incidence. Despite the known genetic component in resilience to PRRSV, there is scarce information regarding the abortive outcome of this disease. We tested the relationship between eight molecular markers (six from published studies and two identified in the present study in the HDAC6 gene) and the probability of abortion during a PRRSV outbreak, using data from two commercial Landrace x Large White sow farms with an incidence of abortion of 35% and 17%. From the markers tested, USP18_-1533G>A did not segregate in these populations, and CD163_c.3534C>T and HDAC6_g.2360C>T did not affect the abortion rate. In contrast, the minor allele of two markers in SSC4 (WUR1000125 in GBP1 and rs340943904 in GBP5), which lower viremia in growing pigs, and the major alleles of CD163_rs1107556229 and HDAC6_rs325981825 were associated with a lower probability of abortion during PRRSV outbreaks. The more striking result was for the MX1 gene, where the odds ratio of aborting versus not aborting was nine times lower in the sows homozygous for a 275-bp insertion than in the other genotypes. Interactions between markers were not relevant. All together, we bring here the first evidence that mutations in the host genome can predispose or protect from complete reproductive failure in sows infected with PRRSV.

1998 ◽  
Vol 1998 ◽  
pp. 114-114
Author(s):  
S. P. Turner ◽  
S. A. Edwards

The requirement for water of growing pigs in large groups has been neglected. Current MAFF recommendations suggest one nipple drinker per 10 pigs, while farmers have often used a ratio of 1 per 20 animals. Neither approach is based on empirical investigation. The relationship between group size and the number of drinking points can not be assumed to be linear. The aim was to assess group size and the two conflicting ratios of drinkers for their effect on welfare, as measured by production performance, drinking and social behaviour.A total of 640 Large White x Landrace growing pigs (start weight 36kg) were housed in a fully slatted commercial grower house for five weeks. Four replicates were used and each animal was assigned to 1 of 4 treatments in a 2 x 2 factorial design of two group sizes (20 vs 60) and two ratios of nipple drinkers to pigs (1:10 vs 1:20). The groups of 20 comprised of pigs from 3 different pens, while 9 pens contributed to the groups of 60. The floor space per pig was maintained constant across treatments. Nine focal pigs (three each of heavy, medium and light weight) were selected from each pen.


2013 ◽  
Vol 58 (No. 4) ◽  
pp. 167-175 ◽  
Author(s):  
L. Che ◽  
P. Yang ◽  
Z. Fang ◽  
Y. Lin ◽  
D. Wu

Arginine (Arg) is considered to have beneficial effects on placental development and function, as well as reproductive performance. The well-developed placenta is highly required in late gestation for rapid fetal growth, however, it is unknown if there is a crucial role of Arg in late gestation. Likewise, the immunological response of sows to Arg needs to be determined. Therefore, this study is designed to investigate the effects of dietary Arg supplementation on reproductive performance and immunity of sows. At day 30 of gestation, sixty sows (Landrace × Large White) were allocated to 3 groups receiving corn and soybean-based control diet (control group, n = 20), control diet supplemented with 1% l-arginine HCl until day 90 of gestation (Arg90 group, n = 20), and control diet supplemented with 1% l-arginine HCl until day 114 of gestation (Arg114 group, n = 20), respectively. Litter performance was recorded at parturition. Blood samples (n = 6) collected at days 30, 90, and 110 of gestation were measured for metabolic and immunological parameters. At parturition, total litter size was not affected by dietary Arg supplementation. As a result of less pigs born dead, however, sows in Arg114 group had more pigs born alive than sows in control group (+1.6 pigs, P < 0.05), total and live litter weights were increased (+1.6~2.1 kg, P < 0.05) in Arg114 group relative to both control and Arg90 groups. Compared with control group, dietary Arg supplementation increased (+12~110%, P < 0.05) plasma levels of ornithine, proline, and arginine at either day 90 (Arg90 and Arg110 groups) or day 110 of gestation (Arg110 group). Moreover, immune response was enhanced in Arg-supplemented sows, as indicated by the increased levels of serum immunoglobulin and porcine reproductive and respiratory syndrome virus (PRRSV) antibody. These findings indicate dietary Arg supplementation can improve litter performance and immune response, and the beneficial effect of Arg on fetal growth is evident in late gestation.


1998 ◽  
Vol 1998 ◽  
pp. 114-114 ◽  
Author(s):  
S. P. Turner ◽  
S. A. Edwards

The requirement for water of growing pigs in large groups has been neglected. Current MAFF recommendations suggest one nipple drinker per 10 pigs, while farmers have often used a ratio of 1 per 20 animals. Neither approach is based on empirical investigation. The relationship between group size and the number of drinking points can not be assumed to be linear. The aim was to assess group size and the two conflicting ratios of drinkers for their effect on welfare, as measured by production performance, drinking and social behaviour.A total of 640 Large White x Landrace growing pigs (start weight 36kg) were housed in a fully slatted commercial grower house for five weeks. Four replicates were used and each animal was assigned to 1 of 4 treatments in a 2 x 2 factorial design of two group sizes (20 vs 60) and two ratios of nipple drinkers to pigs (1:10 vs 1:20). The groups of 20 comprised of pigs from 3 different pens, while 9 pens contributed to the groups of 60. The floor space per pig was maintained constant across treatments. Nine focal pigs (three each of heavy, medium and light weight) were selected from each pen.


2010 ◽  
Vol 50 (9) ◽  
pp. 890 ◽  
Author(s):  
Craig R. G. Lewis ◽  
Tahar Ait-Ali ◽  
Alison Wilson ◽  
Dave G. Westcott ◽  
Jean-Pierre Frossard ◽  
...  

This study examined the effects of porcine reproductive and respiratory syndrome virus (PRRSV) infection on (1) pregnant and (2) growing Landrace and crossbred (Large White × Pietrain) pigs. First, recently pregnant gilts were spilt into a control and a challenged group, which was inoculated with the PRRSV, and phenotypic effects were recorded. In the Landrace breed, infected gilts had a significantly reduced number of fetuses (8.9 versus 11.8), but there were insufficient data to make the same comparison in crossbred gilts. The Landrace had a smaller suppression of weight gain during pregnancy than the crossbred line [56% (0.66 to 0.29 kg/day) versus 85% (0.45 to 0.07 kg/day) reduction], suggesting greater tolerance of the PRRSV infection. Second, impacts on growing pigs were examined with the same deliberate challenge methodology. Some pigs appeared not to become infected from the initial inoculation, but were possibly subsequently infected by cohorts. However, there were indications of Landrace line resistance in terms of an increased time to seroconvert, with weight gain patterns also suggesting Landrace tolerance. In summary, this study demonstrated that breeds differ consistently in phenotypic impacts of PRRSV infection.


Author(s):  
Brynne D. Ovalle ◽  
Rahul Chakraborty

This article has two purposes: (a) to examine the relationship between intercultural power relations and the widespread practice of accent discrimination and (b) to underscore the ramifications of accent discrimination both for the individual and for global society as a whole. First, authors review social theory regarding language and group identity construction, and then go on to integrate more current studies linking accent bias to sociocultural variables. Authors discuss three examples of intercultural accent discrimination in order to illustrate how this link manifests itself in the broader context of international relations (i.e., how accent discrimination is generated in situations of unequal power) and, using a review of current research, assess the consequences of accent discrimination for the individual. Finally, the article highlights the impact that linguistic discrimination is having on linguistic diversity globally, partially using data from the United Nations Educational, Scientific and Cultural Organization (UNESCO) and partially by offering a potential context for interpreting the emergence of practices that seek to reduce or modify speaker accents.


2016 ◽  
Vol 15 (4) ◽  
pp. 143-151 ◽  
Author(s):  
Xiaoming Zheng ◽  
Jun Yang ◽  
Hang-Yue Ngo ◽  
Xiao-Yu Liu ◽  
Wengjuan Jiao

Abstract. Workplace ostracism, conceived as to being ignored or excluded by others, has attracted the attention of researchers in recent years. One essential topic in this area is how to reduce or even eliminate the negative consequences of workplace ostracism. Based on conservation of resources (COR) theory, the current study assesses the relationship between workplace ostracism and its negative outcomes, as well as the moderating role played by psychological capital, using data collected from 256 employees in three companies in the northern part of China. The study yields two important findings: (1) workplace ostracism is positively related to intention to leave and (2) psychological capital moderates the effect of workplace ostracism on affective commitment and intention to leave. This paper concludes by discussing the implications of these findings for organizations and employees, along with recommendations for future research.


EMJ Radiology ◽  
2020 ◽  
Author(s):  
Filippo Pesapane

Radiomics is a science that investigates a large number of features from medical images using data-characterisation algorithms, with the aim to analyse disease characteristics that are indistinguishable to the naked eye. Radiogenomics attempts to establish and examine the relationship between tumour genomic characteristics and their radiologic appearance. Although there is certainly a lot to learn from these relationships, one could ask the question: what is the practical significance of radiogenomic discoveries? This increasing interest in such applications inevitably raises numerous legal and ethical questions. In an environment such as the technology field, which changes quickly and unpredictably, regulations need to be timely in order to be relevant.  In this paper, issues that must be solved to make the future applications of this innovative technology safe and useful are analysed.


2017 ◽  
Vol 5 (2) ◽  
pp. 16
Author(s):  
Ahmad Ghazali Ismail ◽  
Arlinah Abd Rashid ◽  
Azlina Hanif

The relationship and causality direction between electricity consumption and economic growth is an important issue in the fields of energy economics and policies towards energy use. Extensive literatures has discussed the issue, but the array of findings provides anything but consensus on either the existence of relations or direction of causality between the variables. This study extends research in this area by studying the long-run and causal relations between economic growth, electricity consumption, labour and capital based on the neo-classical one sector aggregate production technology mode using data of electricity consumption and real GDP for ASEAN from the year 1983 to 2012. The analysis is conducted using advanced panel estimation approaches and found no causality in the short run while in the long-run, the results indicate that there are bidirectional relationship among variables. This study provides supplementary evidences of relationship between electricity consumption and economic growth in ASEAN.


2020 ◽  
Author(s):  
Serena Stefani ◽  
Gabriele Prati

Research on the relationship between fertility and gender ideology revealed inconsistent results. In the present study, we argue that inconsistencies may be due to the fact that such relationship may be nonlinear. We hypothesize a U- shaped relationship between two dimensions of gender ideology (i.e. primacy of breadwinner role and acceptance of male privilege) and fertility rates. We conducted a cross-national analysis of 60 countries using data from the World Values Survey as well as the World Population Prospects 2019. Controlling for gross domestic product, we found support for a U-shaped relationship between gender ideology and fertility. Higher levels of fertility rates were found at lower and especially higher levels of traditional gender ideology, while a medium level of gender ideology was associated with the lowest fertility rate. This curvilinear relationship is in agreement with the phase of the gender revolution in which the country is located. Traditional beliefs are linked to a complementary division of private versus public sphere between sexes, while egalitarian attitudes are associated with a more equitable division. Both conditions strengthen fertility. Instead, as in the transition phase, intermediate levels of gender ideology’s support are associated with an overload and a difficult reconciliation of the roles that women have to embody (i.e. working and nurturing) so reducing fertility. The present study has contributed to the literature by addressing the inconsistencies of prior research by demonstrating that the relationship between gender ideology and fertility rates is curvilinear rather than linear.


2019 ◽  
Author(s):  
Gabriela Czarnek ◽  
Małgorzata Kossowska

In this study, we investigate the relationship between values and political beliefs and how it varies as a function of cultural context and time. In particular, we analyzed the effects of Conservation vs. Openness to change and Self-transcendence vs. Self-enhancement for cultural and economic political beliefs using data from nationally representative samples of citizens from 34 European countries from eight rounds of the European Social Survey (data spans the 2002–2016 period). We found that the effects of values on political beliefs are moderated by the Western vs. Eastern cultural context and that there is a modest round-to-round variation in the effects of values on beliefs. The relationship between Openness and cultural beliefs was negative and largely consistent across the Western and Eastern countries. Similarly, the effects of Self-enhancement were positive across these Western and Eastern countries. In contrast, the effects of Openness on economic beliefs were positive for the Eastern countries but largely weak and inconsistent for the Western countries. Finally, the effects of Self-enhancement on cultural beliefs are weak for both cultural contexts.


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