scholarly journals [18F] Sodium Fluoride PET Kinetic Parameters in Bone Imaging

Tomography ◽  
2021 ◽  
Vol 7 (4) ◽  
pp. 843-854
Author(s):  
Tanuj Puri ◽  
Michelle L. Frost ◽  
Gary J. Cook ◽  
Glen M. Blake
Keyword(s):  
Kinetic Parameters ◽  
Sodium Fluoride ◽  
Emission Tomography ◽  
Imaging Biomarker ◽  
Bone Imaging ◽  
Positron Emission ◽  
Novel Drugs ◽  
Early Phase Clinical Trials ◽  
Pet Scans ◽  
Bone Physiology

This report describes the significance of the kinetic parameters (k-values) obtained from the analysis of dynamic positron emission tomography (PET) scans using the Hawkins model describing the pharmacokinetics of sodium fluoride ([18F]NaF) to understand bone physiology. Dynamic [18F]NaF PET scans may be useful as an imaging biomarker in early phase clinical trials of novel drugs in development by permitting early detection of treatment-response signals that may help avoid late-stage attrition.

scholarly journals Optimization of radiation exposure in18F-sodium fluoride positron emission tomography-computed tomography in bone imaging: Quo vadis

2019 ◽  
Vol 34 (2) ◽  
pp. 157
Author(s):  
Rashid Rasheed ◽  
Sharjeel Usmani ◽  
SyedAli Raza Naqvi ◽  
Fareeda Alkandari ◽  
FahadA Marafi ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Radiation Exposure ◽  
Sodium Fluoride ◽  
Emission Tomography ◽  
Bone Imaging ◽  
Positron Emission ◽  
Quo Vadis

scholarly journals Bone Imaging with F-18 Sodium Fluoride Positron Emission Tomography

RADIOISOTOPES ◽  
2009 ◽  
Vol 58 (9) ◽  
pp. 629-635
Author(s):  
Masashi KAWAGUCHI ◽  
Kazuya SHIZUKUISHI ◽  
Tomio INOUE
Keyword(s):  
Positron Emission Tomography ◽  
Sodium Fluoride ◽  
Emission Tomography ◽  
Bone Imaging ◽  
Positron Emission

scholarly journals 161 18F-sodium fluoride positron emission tomography in acute aortic syndrome

2021 ◽  
Author(s):  
Maaz Syed ◽  
Alexander Fletcher ◽  
Samuel Debono ◽  
Rachael Forsythe ◽  
Michelle Williams ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Sodium Fluoride ◽  
Emission Tomography ◽  
Acute Aortic Syndrome ◽  
Positron Emission

scholarly journals Effects of administration route on uptake kinetics of 18F-sodium fluoride positron emission tomography in mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Zaniah N. Gonzalez-Galofre ◽  
Carlos J. Alcaide-Corral ◽  
Adriana A. S. Tavares
Keyword(s):  
Positron Emission Tomography ◽  
Sodium Fluoride ◽  
Soft Tissues ◽  
Small Animal ◽  
Phase Changes ◽  
Emission Tomography ◽  
Pharmacokinetic Data ◽  
Administration Route ◽  
Standardised Uptake Value ◽  
Positron Emission

Abstract18F-sodium fluoride (18F-NaF) is a positron emission tomography (PET) radiotracer widely used in skeletal imaging and has also been proposed as a biomarker of active calcification in atherosclerosis. Like most PET radiotracers, 18F-NaF is typically administered intravenously. However in small animal research intravenous administrations can be challenging, because partial paravenous injection is common due to the small calibre of the superficial tail veins and repeat administrations via tail veins can lead to tissue injury therefore limiting the total number of longitudinal scanning points. In this paper, the feasibility of using intra-peritoneal route of injection of 8F-NaF to study calcification in mice was studied by looking at the kinetic and uptake profiles of normal soft tissues and bones versus intra-vascular injections. Dynamic PET was performed for 60 min on nineteen isoflurane-anesthetized male Swiss mice after femoral artery (n = 7), femoral vein (n = 6) or intraperitoneal (n = 6) injection of 8F-NaF. PET data were reconstructed and the standardised uptake value (SUV) and standardised uptake value ratio (SUVr) were estimated from the last three frames between 45- and 60-min and 8F-NaF uptake constant (Ki) was derived by Patlak graphical analysis. In soft tissue, the 18F-NaF perfusion phase changes depending on the type on injection route, whereas the uptake phase is similar regardless of the administration route. In bone tissue SUV, SUVr and Ki measures were not significantly different between the three administration routes. Comparison between PET and CT measures showed that bones that had the highest CT density displayed the lowest PET activity and conversely, bones where CT units were low had high 8F-NaF uptake. Intraperitoneal injection is a valid and practical alternative to the intra-vascular injections in small-animal 18F-NaF PET imaging providing equivalent pharmacokinetic data. CT outcome measures report on sites of stablished calcification whereas PET measures sites of higher complexity and active calcification.

18 F-sodium fluoride positron emission tomography of the equine distal limb: Exploratory study in three horses

2017 ◽  
Vol 50 (1) ◽  
pp. 125-132 ◽  
Author(s):  
M. Spriet ◽  
P. Espinosa ◽  
A. Z. Kyme ◽  
K. L. Phillips ◽  
S. A. Katzman ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Sodium Fluoride ◽  
Exploratory Study ◽  
Emission Tomography ◽  
Distal Limb ◽  
Positron Emission

18F-Sodium Fluoride Positron Emission Tomography/Computed Tomography in Acute Aortic Syndrome

2021 ◽  
Vol 62 (6) ◽  
pp. e88-e89
Author(s):  
Maaz Syed ◽  
Alexander Fletcher ◽  
Marc Dweck ◽  
Rachael Forsythe ◽  
Edwin van Beek ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Sodium Fluoride ◽  
Emission Tomography ◽  
Acute Aortic Syndrome ◽  
Positron Emission

scholarly journals Synthesis, quality control and dosimetry of the radiopharmaceutical 18F-sodium fluoride produced at the Center for Development of Nuclear Technology - CDTN

2010 ◽  
Vol 46 (3) ◽  
pp. 563-569 ◽  
Author(s):  
Marina Bicalho Silveira ◽  
Marcella Araugio Soares ◽  
Eduardo Sarmento Valente ◽  
Samira Soares Waquil ◽  
Andréa Vidal Ferreira ◽  
...  
Keyword(s):  
Quality Control ◽  
Sodium Fluoride ◽  
Radiochemical Purity ◽  
Nuclear Technology ◽  
Physical Chemical ◽  
Positron Emission ◽  
Oncological Diseases ◽  
Pet Scans ◽  
Quality Imaging ◽  
The U.S

18F-Sodium fluoride (Na18F) is a radiopharmaceutical used for diagnosis in nuclear medicine by positron emission tomography (PET) imaging. Bone scintigraphy is normally performed using 99mTc-MDP. However, 18F PET scans promise high quality imaging with increased resolution and improved sensitivity and specificity. In order to make available a tool for more specific studies of tumors and non-oncological diseases of bone tissue, the UPPR/CDTN team undertook the production and quality control of Na18F injectable solution with the physical-chemical, microbiological and biological characteristics recommended in the U.S. Pharmacopeia. Na18F radiochemical purity was 96.7 ± 1.3 %, with Rf= 0.026 ± 0.006. The product presented a pH of 5.3 ± 0.6, half life of 109.0 ± 0.8 minutes, endotoxin limit < 5.0 EU.mL-1 and no microbial contaminants. The biodistribution of Na18F was similar to that described in the literature, with a clearance of 0.19 mL.min-1 and distribution volume of 18.76 mL. The highest bone concentration (5.0 ± 0.5 %ID.g-1) was observed 20 minutes after injection. Na18F produced at the UPPR presented all the quality assurance requirements of the U.S. Pharmacopeia and can be safely used for clinical bone imaging.

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