18 F-sodium fluoride positron emission tomography of the equine distal limb: Exploratory study in three horses

2017 ◽  
Vol 50 (1) ◽  
pp. 125-132 ◽  
Author(s):  
M. Spriet ◽  
P. Espinosa ◽  
A. Z. Kyme ◽  
K. L. Phillips ◽  
S. A. Katzman ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Sodium Fluoride ◽  
Exploratory Study ◽  
Emission Tomography ◽  
Distal Limb ◽  
Positron Emission

POSITRON EMISSION TOMOGRAPHY OF THE EQUINE DISTAL LIMB: EXPLORATORY STUDY

2016 ◽  
Vol 57 (6) ◽  
pp. 630-638 ◽  
Author(s):  
Mathieu Spriet ◽  
Pablo Espinosa ◽  
Andre Z. Kyme ◽  
Pavel Stepanov ◽  
Val Zavarzin ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Exploratory Study ◽  
Emission Tomography ◽  
Distal Limb ◽  
Positron Emission

scholarly journals 161 18F-sodium fluoride positron emission tomography in acute aortic syndrome

2021 ◽  
Author(s):  
Maaz Syed ◽  
Alexander Fletcher ◽  
Samuel Debono ◽  
Rachael Forsythe ◽  
Michelle Williams ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Sodium Fluoride ◽  
Emission Tomography ◽  
Acute Aortic Syndrome ◽  
Positron Emission

scholarly journals Effects of administration route on uptake kinetics of 18F-sodium fluoride positron emission tomography in mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Zaniah N. Gonzalez-Galofre ◽  
Carlos J. Alcaide-Corral ◽  
Adriana A. S. Tavares
Keyword(s):  
Positron Emission Tomography ◽  
Sodium Fluoride ◽  
Soft Tissues ◽  
Small Animal ◽  
Phase Changes ◽  
Emission Tomography ◽  
Pharmacokinetic Data ◽  
Administration Route ◽  
Standardised Uptake Value ◽  
Positron Emission

Abstract18F-sodium fluoride (18F-NaF) is a positron emission tomography (PET) radiotracer widely used in skeletal imaging and has also been proposed as a biomarker of active calcification in atherosclerosis. Like most PET radiotracers, 18F-NaF is typically administered intravenously. However in small animal research intravenous administrations can be challenging, because partial paravenous injection is common due to the small calibre of the superficial tail veins and repeat administrations via tail veins can lead to tissue injury therefore limiting the total number of longitudinal scanning points. In this paper, the feasibility of using intra-peritoneal route of injection of 8F-NaF to study calcification in mice was studied by looking at the kinetic and uptake profiles of normal soft tissues and bones versus intra-vascular injections. Dynamic PET was performed for 60 min on nineteen isoflurane-anesthetized male Swiss mice after femoral artery (n = 7), femoral vein (n = 6) or intraperitoneal (n = 6) injection of 8F-NaF. PET data were reconstructed and the standardised uptake value (SUV) and standardised uptake value ratio (SUVr) were estimated from the last three frames between 45- and 60-min and 8F-NaF uptake constant (Ki) was derived by Patlak graphical analysis. In soft tissue, the 18F-NaF perfusion phase changes depending on the type on injection route, whereas the uptake phase is similar regardless of the administration route. In bone tissue SUV, SUVr and Ki measures were not significantly different between the three administration routes. Comparison between PET and CT measures showed that bones that had the highest CT density displayed the lowest PET activity and conversely, bones where CT units were low had high 8F-NaF uptake. Intraperitoneal injection is a valid and practical alternative to the intra-vascular injections in small-animal 18F-NaF PET imaging providing equivalent pharmacokinetic data. CT outcome measures report on sites of stablished calcification whereas PET measures sites of higher complexity and active calcification.

18F-Sodium Fluoride Positron Emission Tomography/Computed Tomography in Acute Aortic Syndrome

2021 ◽  
Vol 62 (6) ◽  
pp. e88-e89
Author(s):  
Maaz Syed ◽  
Alexander Fletcher ◽  
Marc Dweck ◽  
Rachael Forsythe ◽  
Edwin van Beek ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Sodium Fluoride ◽  
Emission Tomography ◽  
Acute Aortic Syndrome ◽  
Positron Emission

Applications of Artificial Intelligence in 18F-Sodium Fluoride Positron Emission Tomography/Computed Tomography:

PET Clinics ◽  
2022 ◽  
Vol 17 (1) ◽  
pp. 115-135
Author(s):  
Sriram S. Paravastu ◽  
Navid Hasani ◽  
Faraz Farhadi ◽  
Michael T. Collins ◽  
Lars Edenbrandt ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Sodium Fluoride ◽  
Emission Tomography ◽  
Positron Emission
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