scholarly journals Addressing the Selectivity of Enzyme Biosensors: Solutions and Perspectives

Sensors ◽  
2021 ◽  
Vol 21 (9) ◽  
pp. 3038
Author(s):  
Bogdan Bucur ◽  
Cristina Purcarea ◽  
Silvana Andreescu ◽  
Alina Vasilescu

Enzymatic biosensors enjoy commercial success and are the subject of continued research efforts to widen their range of practical application. For these biosensors to reach their full potential, their selectivity challenges need to be addressed by comprehensive, solid approaches. This review discusses the status of enzymatic biosensors in achieving accurate and selective measurements via direct biocatalytic and inhibition-based detection, with a focus on electrochemical enzyme biosensors. Examples of practical solutions for tackling the activity and selectivity problems and preventing interferences from co-existing electroactive compounds in the samples are provided such as the use of permselective membranes, sentinel sensors and coupled multi-enzyme systems. The effect of activators, inhibitors or enzymatic substrates are also addressed by coupled enzymatic reactions and multi-sensor arrays combined with data interpretation via chemometrics. In addition to these more traditional approaches, the review discusses some ingenious recent approaches, detailing also on possible solutions involving the use of nanomaterials to ensuring the biosensors’ selectivity. Overall, the examples presented illustrate the various tools available when developing enzyme biosensors for new applications and stress the necessity to more comprehensively investigate their selectivity and validate the biosensors versus standard analytical methods.

Author(s):  
Ihor Oheruk

Purpose. The purpose of the work is to analyze the application of the second and third parts of Article 3692 of the Criminal Code of Ukraine to officials in the context, that defines them by the Criminal Code of Ukraine in the note to Article 364 of the Criminal Code of Ukraine. Methodology. The methodology includes a comprehensive analysis and synthesis of the available scientific and theoretical material and the formulation of relevant conclusions and recommendations. In the course of the study, the following methods of scientific knowledge were used: terminological, logical-semantic, system-structural, logical-normative. Results: in the course of research the cause of criminalization of such act as "abuse of power" is considered, the subject of the specified criminal act which has the features of "an official" in the context, that defines it by the note to Article 364 of the Criminal Code of Ukraine is analyzed and the main ways of committing criminal acts, that are provided for in this article of the Criminal Code of Ukraine are identified. Originality. The study found, that one of the key conditions for the opportunity to influence officials, that are authorized to perform government or local self-government functions, is the position held by the official and the related opportunities. Therefore, taking into account the opinion of the scientists, that the subject of crimes, that are provided for by the second and third parts of Article 3692 is special, the peculiarities of which is the cumulative feature, that denotes, that such person is not endowed with the status of an official, well-founded need to specify the criminal legislation of Ukraine in terms of the application the second and third parts of Article 3692 of the Criminal code of Ukraine concerning officials in the context, that defines them by the criminal legislation of Ukraine in the note to Article 364 of the Criminal Code of Ukraine. Practical significance. The research results can be used in lawmaking in the improvement of anti-corruption legislation.


1994 ◽  
Vol 18 (2) ◽  
pp. 108-120 ◽  
Author(s):  
Julian Johnson

2020 ◽  
Vol 1 (3) ◽  
pp. 49-56
Author(s):  
Feruza Mamatova ◽  

The present paper aims to compare the principles of choosing a marriage partner and analyse the status of being in the marrriage in the frame of family traditions that are totally inherent to the both of the nations: English and Uzbek. It is known that interconnection and cross-cultural communication between the countries of these two nationalities have been recently developed. The purpose to give an idea about these types of family traditions and prevent any misunderstanding that might occur in the communications makes our investigation topical one. The research used phraseological units as an object and the marriage aspects as the subject


2019 ◽  
Vol 4 (2) ◽  
pp. 134-148
Author(s):  
Mohsi Mohsi

Marriage registration is often the subject of discussion among academics in the aspect of legal legitimacy. Is marriage registration a condition of marriage, or the harmony of marriage ?. From all the discourses available, the writer concludes that the recording of marriage in the al-maslahah review is a new witness system, but cannot replace the position of the witnesses who have been introduced and patented in the construction of classical texts and fiqh. its existence is only as complementary, but it is very mandatory to be fulfilled because it impacts on aspects of marriage, both directly and indirectly, such as to the status of the child on a birth certificate, divorce, and other aspects as a result of a marriage, also divorce.


2012 ◽  
Vol 7 (2) ◽  
pp. 183-193
Author(s):  
Barbara Grzybowska

This paper characterises the directions of innovative activities undertaken by food industry enterprises concerning the manufacturing of food products. Based on the subject literature and secondary statistical data, the status of food industry innovativeness and areas of innovative activities related to implementation of technological and non-technological innovations are presented. The activities of enterprises focus on manufacturing new products in response to the ever-changing needs and expectations of consumers. In particular, the production of so-called functional food (which seeks to promote health, minimise the risk of specific diseases, improve psychophysical fitness, lose weight, etc.) is increasingly extensive. Manufacturers must also improve the technologies and techniques of product manufacturing, packaging and storage. 


1994 ◽  
Vol 11 (1) ◽  
pp. 38-70
Author(s):  
Florence Eid

IntroductionThis paper is a report on the state of research in two areas of Islamicstudies: Islam and economics and Islam and governance. I researched andwrote it as part of my internship at the Ford Foundation during the summerof 1992. On Discourse. The study of Islam in the United States has moved far beyondthe traditional historical and philological methods. This is perhapsbest explained by the development of analytically rigorous social sciencemethods that have contributed to a better balance between the humanisticconcerns of the more traditional approaches and efforts at systematizingthe study of Islam and classifying it across boundaries of communities,religions, even epochs. This is said to have s t a d with the developmentof irenic attitudes towards Islam, which changed the direction of westemorientalist writings from indifference (at best) and often open hostility toand contempt of Islamic values (however they were understood) to phenomenologicalworks by scholars who saw the study of Islam as somethingto be taken seriously and for its own sake, which is best exemplifiedby Clifford Geertz's Islam Observed.The work of Edward Said contested this evolution, and the publicationof his Orientalism has been described as "a stick of dynamite"' that,despite its impact in mobilizing a reevaluation of the field, was unwarrantedin its pessimism. In any case, the field has continued to evolve,with the most powerful force moving it being the subject itself. Thephenomenological/orientalist approach, if we can point to one today, ...


2009 ◽  
Vol 26 (1) ◽  
pp. 1-19
Author(s):  
Muhammad Aziz

This paper analyzes the historical conditions of Yemen’s Sufi movement from the beginning of Islam up to the rise of the Rasulid dynasty in the thirteenth century. This is a very difficult task, given the lack of adequate sources and sufficient academic attention in both the East and theWest. Certainly, a few sentences about the subject can be found scattered in Sufi literature at large, but a respectable study of the period’s mysticism can hardly be found.1 Thus, I will focus on the major authorities who first contributed to the ascetic movement’s development, discuss why a major decline of intellectual activities occurred in many metropolises, and if the existing ascetic conditions were transformed into mystical tendencies during the ninth century due to the alleged impact ofDhu’n-Nun al-Misri (d. 860). This is followed by a brief discussion ofwhat contributed to the revival of the country’s intellectual and economic activities. After that, I will attempt to portray the status of the major ascetics and prominent mystics credited with spreading and diffusing the so-called Islamic saintly miracles (karamat). The trademark of both ascetics and mystics across the centuries, this feature became more prevalent fromthe beginning of the twelfth century onward. I will conclude with a brief note on the most three celebrated figures of Yemen’s religious and cultural history: Abu al-Ghayth ibn Jamil (d. 1253) and his rival Ahmad ibn `Alwan (d. 1266) from the mountainous area, andMuhammad ibn `Ali al-`Alawi, known as al-Faqih al-Muqaddam (d. 1256), from Hadramawt.


Author(s):  
Ralph C.S. Walker

Kant is committed to the reality of a subject self, outside time but active in forming experience. Timeless activity is problematic, but that can be dealt with. But he holds that the subject of experience is not an object of experience, so nothing can be known about it; this raises a problem about the status of his own theory. But he ought to allow that we can know of its existence and activity, as preconditions of experience: the Critique allows that synthetic a priori truths can be known in this way. However, its identity conditions remain unknowable. Kant’s unity of apperception shares much with Locke’s continuity of consciousness, but does not determine the identity of a thing. Personal identity is bodily identity. Only Kant’s moral philosophy justifies recognizing other selves; it could warrant ascribing a similar status to animals.


Author(s):  
Steven C. Pan ◽  
Timothy C. Rickard ◽  
Robert A. Bjork

AbstractA century ago, spelling skills were highly valued and widely taught in schools using traditional methods, such as weekly lists, drill exercises, and low- and high-stakes spelling tests. That approach was featured in best-selling textbooks such as the Horn-Ashbaugh Speller of 1920. In the early 21st century, however, skepticism as to the importance of spelling has grown, some schools have deemphasized or abandoned spelling instruction altogether, and there has been a proliferation of non-traditional approaches to teaching spelling. These trends invite a reevaluation of the role of spelling in modern English-speaking societies and whether the subject should be explicitly taught (and if so, what are research-supported methods for doing so). In this article, we examine the literature to address whether spelling skills are still important enough to be taught, summarize relevant evidence, and argue that a comparison of common approaches to spelling instruction in the early 20th century versus more recent approaches provides some valuable insights. We also discuss the value of explicit spelling instruction and highlight potentially effective ways to implement such instruction, including the use of spelling tests. Overall, our goals are to better characterize the role of spelling skills in today’s society and to identify several pedagogical approaches—some derived from traditional methods and others that are more recent—that hold promise for developing such skills in efficient and effective ways.


Sign in / Sign up

Export Citation Format

Share Document