Noninvasive Measurement of Tongue Pressure and Its Correlation with Swallowing and Respiration

Wann-Yun Shieh; Chin-Man Wang; Hsin-Yi Kathy Cheng; Titilianty Ignatia Imbang

doi:10.3390/s21082603

Noninvasive Measurement of Tongue Pressure and Its Correlation with Swallowing and Respiration

Sensors ◽

10.3390/s21082603 ◽

2021 ◽

Vol 21 (8) ◽

pp. 2603

Author(s):

Wann-Yun Shieh ◽

Chin-Man Wang ◽

Hsin-Yi Kathy Cheng ◽

Titilianty Ignatia Imbang

Keyword(s):

Oral Cavity ◽

Hard Palate ◽

Critical Role ◽

Thyroid Cartilage ◽

Tongue Pressure ◽

Automatic Identification ◽

Strong Positive Correlation ◽

Muscle Movement ◽

Nasal Flow ◽

Intrinsic Muscles

Tongue pressure plays a critical role in the oral and pharyngeal stages of swallowing, contributing considerably to bolus formation and manipulation as well as to safe transporting of food from the mouth to the stomach. Smooth swallowing relies not only on effective coordination of respiration and pharynx motions but also on sufficient tongue pressure. Conventional methods of measuring tongue pressure involve attaching a pressure sheet to the hard palate to monitor the force exerted by the tongue tip against the hard palate. In this study, an air bulb was inserted in the anterior oral cavity to monitor the pressure exerted by the extrinsic and intrinsic muscles of the tongue. The air bulb was integrated into a noninvasive, multisensor approach to evaluate the correlation of the tongue pressure with other swallowing responses, such as respiratory nasal flow, submental muscle movement, and thyroid cartilage excursion. An autodetection program was implemented for the automatic identification of swallowing patterns and parameters from each sensor. The experimental results indicated that the proposed method is sensitive in measuring the tongue pressure, and the tongue pressure was found to have a strong positive correlation with the submental muscle movement during swallowing.

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Sequential Coordination between Lingual and Pharyngeal Pressures Produced during Dry Swallowing

BioMed Research International ◽

10.1155/2014/691352 ◽

2014 ◽

Vol 2014 ◽

pp. 1-10 ◽

Cited By ~ 8

Author(s):

Jitsuro Yano ◽

Yoichiro Aoyagi ◽

Takahiro Ono ◽

Kazuhiro Hori ◽

Wakami Yamaguchi ◽

...

Keyword(s):

Strong Correlation ◽

Healthy Subjects ◽

Hard Palate ◽

Flow Dynamics ◽

Tongue Pressure ◽

Pressure Flow ◽

Measuring Point ◽

Pharyngeal Pressure ◽

Median Part ◽

Significant Difference

The aim of this study was to investigate oropharyngeal pressure flow dynamics during dry swallowing in ten healthy subjects. Tongue pressure (TP) was measured using a sensor sheet system with five measuring points on the hard palate, and pharyngeal pressure (PP) was measured using a manometric catheter with four measuring points. The order and correlations of sequential events, such as onset, peak, and offset times of pressure production, at each pressure measuring point were analyzed on the synchronized waveforms. Onset of TP was earlier than that of PP. The peak of TP did not show significant differences with the onset of PP, and it was earlier than that of PP. There was no significant difference between the offset of TP and PP. The onset of PP was temporally time-locked to the peak of TP, and there was an especially strong correlation between the onset of PP and TP at the posterior-median part on the hard palate. The offset of PP was temporally time-locked to that of TP. These results could be interpreted as providing an explanation for the generation of oropharyngeal pressure flow to ensure efficient bolus transport and safe swallowing.

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Lipoprotein profiles in SCID/uPA mice transplanted with human hepatocytes become human-like and correlate with HCV infection success

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.00200.2010 ◽

2010 ◽

Vol 299 (4) ◽

pp. G844-G854 ◽

Cited By ~ 19

Author(s):

Rineke H. G. Steenbergen ◽

Michael A. Joyce ◽

Garry Lund ◽

Jamie Lewis ◽

Ran Chen ◽

...

Keyword(s):

Critical Role ◽

Human Hepatocytes ◽

Hcv Infection ◽

Strong Positive Correlation ◽

Chimeric Mice ◽

Human Apolipoprotein ◽

Weakest Link ◽

Successful Infection ◽

Human Livers ◽

Lipoprotein Profiles

Although multiple determinants for hepatitis C virus (HCV) infection are known, it remains partly unclear what determines the human specificity of HCV infection. Presumably, the presence of appropriate entry receptors is essential, and this may explain why HCV is unable to infect nonhuman hepatocytes. However, using mice with chimeric human livers, we show in this study that the presence of human hepatocytes, and therefore human entry receptors, is not sufficient for HCV infection. In successfully transplanted SCID/Alb-uPA mice, infection with HCV is reliable only when ∼70–80% of the liver consists of human hepatocytes. We show that chimeric mice, which are hard to infect with HCV, have significant groups of human hepatocytes that are readily infected with hepatitis B virus. Thus it is unlikely that the lack of infection with HCV can simply be attributed to low hepatocyte numbers. We investigated whether the humanization of lipoprotein profiles is positively associated with infection success. We show that the lipoprotein profiles of chimeric mice become more human-like at high levels of engraftment of human hepatocytes. This and expression of markers of human lipoprotein biosynthesis, human apolipoprotein B (ApoB) and cholesterol ester transfer protein (CETP), show a strong positive correlation with successful infection. Association of HCV in the blood of chimeric mice to ApoB-containing lipoproteins is comparable to association of HCV in patient serum and provides further support for a critical role for ApoB-containing lipoproteins in the infectious cycle of HCV. Our data suggest that the weakest link in the HCV infection chain does not appear to be the presence of human hepatocytes per se. We believe that HCV infection also depends on the presence of sufficient levels of human lipoproteins.

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Management of the neck and regional recurrence in squamous cell carcinoma of the maxillary alveolus and hard palate compared with other sites in the oral cavity

Head & Neck ◽

10.1002/hed.22957 ◽

2012 ◽

Vol 35 (2) ◽

pp. 265-269 ◽

Cited By ~ 32

Author(s):

James S. Brown ◽

Fazilet Bekiroglu ◽

Richard J. Shaw ◽

Julia A. Woolgar ◽

Simon N. Rogers

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Hard Palate ◽

Regional Recurrence

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Evaluation of volume change in oral cavity proper before and after mandibular advancement:

The Angle Orthodontist ◽

10.2319/052420-474.1 ◽

2020 ◽

Vol 91 (1) ◽

pp. 81-87

Author(s):

Balaji Rajkumar ◽

Ratna Parameswaran ◽

Anantanarayanan Parameswaran ◽

Devaki Vijayalakshmi

Keyword(s):

Oral Cavity ◽

Statistical Significance ◽

Mean Difference ◽

Mandibular Advancement ◽

Strong Positive Correlation ◽

Positive Correlation ◽

High Statistical Significance ◽

Proper Volume ◽

The Mean ◽

Tongue Volume

ABSTRACT Objectives To evaluate the tongue and oral cavity proper volume in pre- and post-bilateral sagittal split osteotomy (BSSO) patients, and to establish whether there was a correlation between them. Materials and Methods A retrospective study that evaluated 12 patients' pre- and post-surgical computed tomography records satisfying the inclusion criteria. Borders were defined for measurement of tongue and oral cavity proper volume. The volume assessment was carried out using 3D slice software. Results The mean difference of tongue volume was 5.7 ± 1.7 cm3, which showed high statistical significance. The mean difference of oral cavity proper volume (OCVP) was 6.9 ± 3.4 cm3 and indicated high statistical significance. A very strong positive correlation existed between pre- and post-surgical tongue volume. Positive correlation was also evident between pre and post - surgical OCVP. Medium positive correlation was noted when the difference between pre- and post-surgical tongue and OCVP were assessed. Conclusions There was a significant change in volume of tongue and oral cavity proper after BSSO advancement surgery. The space around the tongue, position of tongue, and maxillary and mandibular relationship influence the volume of tongue and oral cavity proper.

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Surgical Management of Necrotizing Sialometaplasia of Hard Palate: A Case Report

International Journal of Current Science Research and Review ◽

10.47191/ijcsrr/v3-i12-03 ◽

2020 ◽

Vol 03 (12) ◽

Author(s):

Indu Palanivel ◽

Keyword(s):

Case Report ◽

Oral Cavity ◽

Surgical Management ◽

Conservative Management ◽

Hard Palate ◽

Complete Regression ◽

Self Healing ◽

Healing Period ◽

Necrotizing Sialometaplasia

Necrotizing Sialometaplasia is rare and in the oral cavity it accounts <1% of all biopsied lesion. For decades Necrotizing Sialometaplasia were treated by conservative management as it is a self healing lesion. The progressive healing period was reported from 2 weeks to 3 months in the literature. Is necrotizing sialometaplasia a self-limiting disease? Here we report a case of non-healing necrotizing sialometaplasia which was treated by surgical management. Complete regression of the lesion was evident after the surgical management and no recurrence until two years of follow-up.

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Solitary fibrous tumor of the hard palate: a rare entity in oral cavity

Brazilian Dental Science ◽

10.14295/bds.2016.v19i1.1148 ◽

2016 ◽

Vol 19 (1) ◽

pp. 113

Author(s):

Antonione Santos Bezerra Pinto ◽

Vera Cavalcanti De Araújo ◽

Fabrício Passador Santos ◽

José Ferreira de Menezes Filho ◽

Viviane Siqueira ◽

...

Keyword(s):

Oral Cavity ◽

Solitary Fibrous Tumor ◽

Hard Palate ◽

Salivary Gland Tumor ◽

Immunohistochemical Analysis ◽

Soft Tissue Tumors ◽

Rare Entity ◽

Gland Tumor ◽

Clinical Imaging ◽

Fibrous Tumor

A case of solitary fibrous tumor is reported. Solitary fibrous tumor is a rare neoplasia characterized by the proliferation of fusiform cells of mesenchymal origin accounting for at least 2% of all soft tissue tumors. In this present case, the initial diagnosis was salivary gland tumor because of the location in the hard palate. Histologically, the tumor was composed by conjunctive tissue with proliferation of oval and fusiform cells. The immunohistochemical analysis was positive for CD34 and CD99. The lesion was treated by surgical resection. The clinical, imaging, histological and immunohistochemical data are discussed in this study. KeywordsSolitary fibrous tumor; Oral cavity; Hard palate; Differential diagnosis.

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S155 – Spontaneous Regression of Mucosal Melanoma

Otolaryngology ◽

10.1016/j.otohns.2008.05.329 ◽

2008 ◽

Vol 139 (2_suppl) ◽

pp. P128-P128

Author(s):

Roy Rajan ◽

Sandeep Samant

Keyword(s):

Hard Palate ◽

Spontaneous Regression ◽

Spindle Cell ◽

Critical Role ◽

Mucosal Melanoma ◽

Cell Type ◽

Pigmented Lesion ◽

Pet Ct ◽

S 100 ◽

Histopathologic Findings

Objectives Spontaneous regression of melanoma is a rare phenomenon, and it has yet to be described in the literature for mucosal melanomas, which ordinarily have a grim prognosis with a 10–15%, 5-year survival rate. We present a case of a hard palate melanoma that spontaneously regressed. Methods We present a case report, review of the literature, and a discussion. Results A 49-year-old female presented with a pigmented lesion recently on her hard palate that was biopsy-proven to be spindle-cell type malignant melanoma with a depth of 2.3 mm. It stained positive for S-100 and Melan-A. Subsequent PET/CT imaging did not show hypermetabolic activity either at the lesion or elsewhere. A wide local excision of the lesion was performed. The histopathology showed oral mucosa with focal cicatrix formation, chronic inflammation, and pigmented macrophages, but no evidence of residual melanoma. Conclusions The case illustrates histopathologic findings in a mucosal melanoma undergoing spontaneous regression. These findings point to a potentially critical role for histiocytes in effecting tumor elimination. Analysis of spontaneous melanoma regression may help understand this phenomenon better and may lead to improved immunotherapy.

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Association between the microbiomes of tonsil and saliva samples isolated from pediatric patients subjected to tonsillectomy for the treatment of tonsillar hyperplasia

Experimental & Molecular Medicine ◽

10.1038/s12276-020-00487-6 ◽

2020 ◽

Vol 52 (9) ◽

pp. 1564-1573

Author(s):

Da Hyeon Choi ◽

Jiwon Park ◽

Ju Kwang Choi ◽

Kyeong Eun Lee ◽

Won Hee Lee ◽

...

Keyword(s):

Oral Cavity ◽

Microbial Communities ◽

Alpha Diversity ◽

16S Rrna Gene Sequencing ◽

Diversity Indices ◽

Rrna Gene ◽

Strong Positive Correlation ◽

Korean Children ◽

Positive Correlation ◽

Tonsillar Hyperplasia

Abstract Oral microbes have the capacity to spread throughout the gastrointestinal system and are strongly associated with multiple diseases. Given that tonsils are located between the oral cavity and the laryngopharynx at the gateway of the alimentary and respiratory tracts, tonsillar tissue may also be affected by microbiota from both the oral cavity (saliva) and the alimentary tract. Here, we analyzed the distribution and association of the microbial communities in the saliva and tonsils of Korean children subjected to tonsillectomy because of tonsil hyperplasia (n = 29). The microbiome profiles of saliva and tonsils were established via 16S rRNA gene sequencing. Based on the alpha diversity indices, the microbial communities of the two groups showed high similarities. According to Spearman’s ranking correlation analysis, the distribution of Treponema, the causative bacterium of periodontitis, in saliva and tonsils was found to have a significant positive correlation. Two representative microbes, Prevotella in saliva and Alloprevotella in tonsils, were negatively correlated, while Treponema 2 showed a strong positive correlation between saliva and tonsils. Taken together, strong similarities in the microbial communities of the tonsils and saliva are evident in terms of diversity and composition. The saliva microbiome is expected to significantly affect the tonsil microbiome. Furthermore, we suggest that our study creates an opportunity for tonsillar microbiome research to facilitate the development of novel microbiome-based therapeutic strategies.

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Massive chondrogenic osteosarcoma of the maxilla: A case report

Bangladesh Journal of Medical Science ◽

10.3329/bjms.v10i1.7322 ◽

1970 ◽

Vol 10 (1) ◽

pp. 57-59

Author(s):

M Irfan ◽

RR Ramli ◽

AK Shamim ◽

A Pohchi

Keyword(s):

Case Report ◽

Surgical Treatment ◽

Oral Cavity ◽

Head And Neck ◽

Hard Palate ◽

Medical Science ◽

Bone Cancer ◽

Wide Margin ◽

Primary Bone

Although osteosarcoma is the most common primary bone cancer, the incidence in head and neck bony structures is extremely low. As the surgical treatment requires a wide margin excision, the operation usually will be very challenging especially if it involves midline structures. We report a case of a young gentleman who had a bony growth over the epicenter of the hard palate which rapidly occupies the whole oral cavity within 6 months duration. The outline of management is discussed. Keywords: Osteosarcoma; hard palate. DOI: 10.3329/bjms.v10i1.7322 Bangladesh Journal of Medical Science Vol.10 No.1 Jan 2010 pp.57-59

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Pyogenic granuloma - report of three cases in rare sites

Bangladesh Journal of Medical Science ◽

10.3329/bjms.v12i4.16667 ◽

2013 ◽

Vol 12 (4) ◽

pp. 445-448

Author(s):

AN Sulabha ◽

S Choudhari ◽

G Suchitra

Keyword(s):

Oral Cavity ◽

Buccal Mucosa ◽

Hard Palate ◽

Medical Science ◽

Surgical Excision ◽

Pyogenic Granuloma ◽

Patient Treatment ◽

Young Females ◽

One Year

Pyogenic granuloma is a benign, localized mass of exuberant granulation tissue produced in response to various stimuli. It is inflammatory hyperplasia of oral cavity commonly seen on gingival area and rarely on other parts of oral cavity such as lips, tongue, palate and buccal mucosa. It is seen predominantly in 2nd to 3rd decade of life in young females. Clinically manifesting as small red erythematous exophytic lesion, it must be biopsied to rule out other serious conditions. This article aims to present three cases of extra gingival pyogenic granulomas occurring in rare sites such as buccal mucosa, anterior hard palate and alveolar mucosa of completely edentulous ridge in maxilla. Pyogenic granuloma on buccal mucosa and anterior hard palate were seen in female patients with age of 40 years and 34 years respectively and pyogenic granuloma on alveolar mucosa of edentulous ridge in maxilla was noted in 70 years old male patient. Surgical excision was performed for all the lesion and follow up of one year did not show any recurrence. Please add little description of patient + treatment + followup results. DOI: http://dx.doi.org/10.3329/bjms.v12i4.16667 Bangladesh Journal of Medical Science Vol. 12 No. 04 October 13 Page 445-448

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