scholarly journals Binary Amplitude Reflection Gratings for X-ray Shearing and Hartmann Wavefront Sensors

Sensors ◽  
2021 ◽  
Vol 21 (2) ◽  
pp. 536
Author(s):  
Kenneth A. Goldberg ◽  
Antoine Wojdyla ◽  
Diane Bryant
Keyword(s):  
Operating Conditions ◽  
Design Parameters ◽  
Wavefront Aberration ◽  
Light Sources ◽  
Wavefront Sensors ◽  
X Ray ◽  
New Class ◽  
Coherent Wave ◽  
Reflection Gratings ◽  
Dynamic Operating

New, high-coherent-flux X-ray beamlines at synchrotron and free-electron laser light sources rely on wavefront sensors to achieve and maintain optimal alignment under dynamic operating conditions. This includes feedback to adaptive X-ray optics. We describe the design and modeling of a new class of binary-amplitude reflective gratings for shearing interferometry and Hartmann wavefront sensing. Compact arrays of deeply etched gratings illuminated at glancing incidence can withstand higher power densities than transmission membranes and can be designed to operate across a broad range of photon energies with a fixed grating-to-detector distance. Coherent wave-propagation is used to study the energy bandwidth of individual elements in an array and to set the design parameters. We observe that shearing operates well over a ±10% bandwidth, while Hartmann can be extended to ±30% or more, in our configuration. We apply this methodology to the design of a wavefront sensor for a soft X-ray beamline operating from 230 eV to 1400 eV and model shearing and Hartmann tests in the presence of varying wavefront aberration types and magnitudes.

LED MODULE WITH ELECTRONIC ILLUMINATION CONTROL

2019 ◽  
Vol 1 (12) ◽  
pp. 146-154
Author(s):  
V. Lisovenko ◽  
D. Lisovenko ◽  
O. Bazyk
Keyword(s):  
High Precision ◽  
Single Point ◽  
Dynamic Control ◽  
Directional Pattern ◽  
Current Strength ◽  
Design Parameters ◽  
Light Sources ◽  
Computer Design ◽  
Light Power ◽  
Electron Dynamic

Many energy saving tasks can be solved thanks to the current advances in LED technology in the production of semiconductor light sources. Modern production of solid-state LEDs guarantees high-precision compliance with the calculated design parameters of illumination devices. This opens up wide opportunities for high-precision control of the lighting parameters of a multicomponent module: light power, a directional pattern and a distribution of illumination. Today, the methodical issues of the preliminary modeling of LED illumination devices with the given parameters are fundamentally solved. There is a shift from manual calculations to computer design and need to develop and select the most effective mathematical modeling methods. The paper presents a consistent approach to the modeling of the distribution of illumination on a horizontal plane from the planar LED module, based on the Lambert type of radiation of a single point source. Simple mathematical expressions, programmed on a personal computer, are obtained. The example of a 25-LED floodlight has shown the ability of dynamic control the lighting characteristics of the module. Connecting patterns of separate LEDs or their groups allow to change the direction pattern of the lamp by the appropriate way of switching diodes with different aperture of radiation. The lighting power can be controlled within the linearity of the ampere-brightness characteristics by changing the current strength through the LED. The static selection of characteristics is controlled by the geometry of the location of discrete sources. The formation of uniform illumination of the plane is graphically illustrated. The electron-dynamic way of controlling the lighting parameters of the LED floodlight is confirmed by the inventor’s certificate.

Recent Development of Small Molecule Glutaminase Inhibitors

2018 ◽  
Vol 18 (6) ◽  
pp. 432-443 ◽  
Author(s):  
Minsoo Song ◽  
Soong-Hyun Kim ◽  
Chun Young Im ◽  
Hee-Jong Hwang
Keyword(s):  
Small Molecule ◽  
Cell Metabolism ◽  
Phase 1 ◽  
Vital Role ◽  
Glutamine Metabolism ◽  
Inhibition Mechanism ◽  
Tumor Cell Growth ◽  
X Ray ◽  
New Class ◽  
Preclinical And Clinical Studies

Glutaminase (GLS), which is responsible for the conversion of glutamine to glutamate, plays a vital role in up-regulating cell metabolism for tumor cell growth and is considered to be a valuable therapeutic target for cancer treatment. Based on this important function of glutaminase in cancer, several GLS inhibitors have been developed in both academia and industry. Most importantly, Calithera Biosciences Inc. is actively developing the glutaminase inhibitor CB-839 for the treatment of various cancers, and it is currently being evaluated in phase 1 and 2 clinical trials. In this review, recent efforts to develop small molecule glutaminase inhibitors that target glutamine metabolism in both preclinical and clinical studies are discussed. In particular, more emphasis is placed on CB-839 because it is the only small molecule GLS inhibitor being studied in a clinical setting. The inhibition mechanism is also discussed based on X-ray structure studies of thiadiazole derivatives present in glutaminase inhibitor BPTES. Finally, recent medicinal chemistry efforts to develop a new class of GLS inhibitors are described in the hopes of providing useful information for the next generation of GLS inhibitors.

scholarly journals Tuning π-Acceptor/σ-Donor Ratio of the 2-Isocyanoazulene Ligand: Non-Fluorinated Rival of Pentafluorophenyl Isocyanide and Trifluorovinyl Isocyanide Discovered

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 981
Author(s):  
Mason D. Hart ◽  
John J. Meyers ◽  
Zachary A. Wood ◽  
Toshinori Nakakita ◽  
Jason C. Applegate ◽  
...  
Keyword(s):  
Charge Transfer ◽  
Coordination Chemistry ◽  
Single Crystal ◽  
13C Nmr ◽  
Quantitative Assessment ◽  
X Ray ◽  
New Class ◽  
Linear Relationships ◽  
Ligand Charge Transfer ◽  
Donor Characteristics

Isocyanoazulenes (CNAz) constitute a relatively new class of isocyanoarenes that offers rich structural and electronic diversification of the organic isocyanide ligand platform. This article considers a series of 2-isocyano-1,3-X2-azulene ligands (X = H, Me, CO2Et, Br, and CN) and the corresponding zero-valent complexes thereof, [(OC)5Cr(2-isocyano-1,3-X2-azulene)]. Air- and thermally stable, X-ray structurally characterized 2-isocyano-1,3-dimethylazulene may be viewed as a non-benzenoid aromatic congener of 2,6-dimethyphenyl isocyanide (2,6-xylyl isocyanide), a longtime “workhorse” aryl isocyanide ligand in coordination chemistry. Single crystal X-ray crystallographic {Cr–CNAz bond distances}, cyclic voltametric {E1/2(Cr0/1+)}, 13C NMR {δ(13CN), δ(13CO)}, UV-vis {dπ(Cr) → pπ*(CNAz) Metal-to-Ligand Charge Transfer}, and FTIR {νN≡C, νC≡O, kC≡O} analyses of the [(OC)5Cr(2-isocyano-1,3-X2-azulene)] complexes provided a multifaceted, quantitative assessment of the π-acceptor/σ-donor characteristics of the above five 2-isocyanoazulenes. In particular, the following inverse linear relationships were documented: δ(13COtrans) vs. δ(13CN), δ(13COcis) vs. δ(13CN), and δ(13COtrans) vs. kC≡O,trans force constant. Remarkably, the net electron withdrawing capability of the 2-isocyano-1,3-dicyanoazulene ligand rivals those of perfluorinated isocyanides CNC6F5 and CNC2F3.

scholarly journals Multi-Scale Studies of 3D Printed Mn–Na–W/SiO2 Catalyst for Oxidative Coupling of Methane

Catalysts ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 290
Author(s):  
Tim Karsten ◽  
Vesna Middelkoop ◽  
Dorota Matras ◽  
Antonis Vamvakeros ◽  
Stephen Poulston ◽  
...  
Keyword(s):  
Oxidative Coupling ◽  
Oxidative Coupling Of Methane ◽  
Operating Conditions ◽  
Homogeneous Distribution ◽  
Silica Support ◽  
X Ray Diffraction ◽  
Cross Sectional ◽  
X Ray ◽  
Multi Scale ◽  
3D Printed

This work presents multi-scale approaches to investigate 3D printed structured Mn–Na–W/SiO2 catalysts used for the oxidative coupling of methane (OCM) reaction. The performance of the 3D printed catalysts has been compared to their conventional analogues, packed beds of pellets and powder. The physicochemical properties of the 3D printed catalysts were investigated using scanning electron microscopy, nitrogen adsorption and X-ray diffraction (XRD). Performance and durability tests of the 3D printed catalysts were conducted in the laboratory and in a miniplant under real reaction conditions. In addition, synchrotron-based X-ray diffraction computed tomography technique (XRD-CT) was employed to obtain cross sectional maps at three different positions selected within the 3D printed catalyst body during the OCM reaction. The maps revealed the evolution of catalyst active phases and silica support on spatial and temporal scales within the interiors of the 3D printed catalyst under operating conditions. These results were accompanied with SEM-EDS analysis that indicated a homogeneous distribution of the active catalyst particles across the silica support.

scholarly journals ESA’s X-Ray Astronomy Mission, XMM

1990 ◽  
Vol 123 ◽  
pp. 129-140
Author(s):  
B.G. Taylor ◽  
A. Peacock
Keyword(s):  
Resolving Power ◽  
Science Program ◽  
Eccentric Orbit ◽  
Ccd Cameras ◽  
Optical Telescope ◽  
X Ray ◽  
Medium Resolution ◽  
Reflection Gratings ◽  
Better Than

AbstractESA’s X-ray Astronomy Mission, XMM, scheduled for launch in 1998, is the second of four cornerstones of ESA’s long term science program Horizon 2000. Covering the range from about 0.1 to 10 keV, it will provide a high throughput of 5000 cm2 at 7 keV with three independant telescopes, and have a spatial resolution better than 30 arcsec. Broadband spectrophotometry is provided by CCD cameras while reflection gratings provide medium resolution spectroscopy (resolving power of about 400) in the range 0.3–3 keV. Long uninterrupted observations will be made from the 24 hr period, highly eccentric orbit, reaching a sensitivity approaching 10−15 erg cm−2 s−1 in one orbit. A 30 cm UV/optical telescope is bore-sighted with the x-ray telescopes to provide simultaneous optical counterparts to the numerous serendipitous X-ray sources which will be detected during every observation.

Monitoring of Fluctuations in the Physical and Chemical Properties of a High-Calcium Fly Ash

1987 ◽  
Vol 113 ◽  
Author(s):  
Scott Schlorholtz ◽  
Ken Bergeson ◽  
Turgut Demirel
Keyword(s):  
Fly Ash ◽  
Chemical Properties ◽  
Operating Conditions ◽  
Physical And Chemical Properties ◽  
X Ray Diffraction ◽  
X Ray ◽  
Morphological Studies ◽  
High Calcium ◽  
Physical And Chemical ◽  
And Chemical Properties

ABSTRACTThe physical and chemical properties of fly ash produced at Ottumwa Generating Station have been monitored since April, 1985. The fly ash is produced from burning a low sulfur, sub-bituminous coal obtained from the Powder River Basin near Gillette, Wyoming. One-hundred and sixty samples of fly ash were obtained during the two year period. All of the samples were subjected to physical testing as specified by ASTM C 311. About one-hundred of the samples were also subjected to a series of tests designed to monitor the self-cementing properties of the fly ash. Many of the fly ash samples were subjected to x-ray diffraction and fluorescence analysis to define the mineralogical and chemical composition of the bulk fly ash as a function of sampling date. Hydration products in selected hardened fly ash pastes, were studied by x-ray diffraction and scanning electron microscopy. The studies indicated that power plant operating conditions influenced the compressive strength of the fly ash paste specimens. Mineralogical and morphological studies of the fly ash pastes indicated that stratlingite formation occurred in the highstrength specimens, while ettringite was the major hydration product evident in the low-strength specimens.

Acnistins, a new class of steroidal lactones from Acnistus ramiflorum Miers; X-ray structure of acnistin E

1980 ◽  
pp. 854 ◽  
Author(s):  
Alfredo Usubillaga ◽  
G. de Castellano ◽  
V. Zabel ◽  
William H. Watson
Keyword(s):  
X Ray ◽  
New Class

Impact of Operating Conditions and Design Parameters on Gas Turbine Hot Section Creep Life

2010 ◽  
Author(s):  
S. Eshati ◽  
M. F. Abdul Ghafir ◽  
P. Laskaridis ◽  
Y. G. Li
Keyword(s):  
Gas Turbines ◽  
Performance Model ◽  
Operating Conditions ◽  
Creep Model ◽  
Design Parameters ◽  
Gas Temperature ◽  
Creep Life ◽  
Cooling Effectiveness ◽  
Radial Temperature ◽  
The Impact

This paper investigates the relationship between design parameters and creep life consumption of stationary gas turbines using a physics based life model. A representative thermodynamic performance model is used to simulate engine performance. The output from the performance model is used as an input to the physics based model. The model consists of blade sizing model which sizes the HPT blade using the constant nozzle method, mechanical stress model which performs the stress analysis, thermal model which performs thermal analysis by considering the radial distribution of gas temperature, and creep model which using the Larson-miller parameter to calculate the lowest blade creep life. The effect of different parameters including radial temperature distortion factor (RTDF), material properties, cooling effectiveness and turbine entry temperatures (TET) is investigated. The results show that different design parameter combined with a change in operating conditions can significantly affect the creep life of the HPT blade and the location along the span of the blade where the failure could occur. Using lower RTDF the lowest creep life is located at the lower section of the span, whereas at higher RTDF the lowest creep life is located at the upper side of the span. It also shows that at different cooling effectiveness and TET for both materials the lowest blade creep life is located between the mid and the tip of the span. The physics based model was found to be simple and useful tool to investigate the impact of the above parameters on creep life.

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