scholarly journals It May Be Possible to Prevent both Early and Late Relapses in Breast Cancer; Perhaps This Is an Opportunity for Sensors or Biosensors to Help

Sensors ◽  
2020 ◽  
Vol 20 (24) ◽  
pp. 7261
Author(s):  
Michael Retsky
Keyword(s):  
Breast Cancer ◽  
Relapse Pattern ◽  
Treated Breast ◽  
Treated Breast Cancer

Data presented in 1993 showed an unexpected bimodal relapse pattern in surgically treated breast cancer [...]

Gemcitabine and capecitabine in combination for advanced anthracycline and taxane pre-treated breast cancer patients: A phase II study

2009 ◽  
Vol 49 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Annika Malmström ◽  
Jörgen Hansen ◽  
Lena Malmberg ◽  
Lena Carlsson ◽  
Jan-Henry Svensson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Phase Ii ◽  
Phase Ii Study ◽  
Breast Cancer Patients ◽  
Treated Breast ◽  
Treated Breast Cancer

Endometrial Carcinoma in Tamoxifen-Treated Breast Cancer Patients

1991 ◽  
Vol 3 (4) ◽  
pp. 267-270 ◽  
Author(s):  
G. Spinelli ◽  
N. Bardazzi ◽  
A. Citernesi ◽  
M. Fontanarosa ◽  
P. Curiel
Keyword(s):  
Breast Cancer ◽  
Endometrial Carcinoma ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Treated Breast ◽  
Treated Breast Cancer

Beneficial effects of the redox-active complex Cu[15]pyN5 in doxorubicin-treated breast cancer cells

2012 ◽  
Vol 53 ◽  
pp. S119-S120
Author(s):  
A.S. Fernandes⁎ ◽  
M. Cipriano ◽  
J. Costa ◽  
M.F. Cabral ◽  
J. Miranda ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Active Complex ◽  
Beneficial Effects ◽  
Redox Active ◽  
Treated Breast ◽  
Treated Breast Cancer

scholarly journals MiR-9-3p regulates the biological functions and drug resistance of gemcitabine-treated breast cancer cells and affects tumor growth through targeting MTDH

2021 ◽  
Vol 12 (10) ◽  
Author(s):  
Yike Wang ◽  
Lifeng Dong ◽  
Fang Wan ◽  
Fangfang Chen ◽  
Dianlei Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Breast Cancer Cells ◽  
Biological Functions ◽  
Qrt Pcr ◽  
Treated Breast ◽  
Cancer Tissues ◽  
Treated Breast Cancer

AbstractThis study explored the role of MTDH in regulating the sensitivity of breast cancer cell lines to gemcitabine (Gem) and the potential miRNAs targeting MTDH. The expression of MTDH in cancer tissues and cells was detected by immunohistochemical staining or qRT-PCR. The target genes for MTDH were predicted by bioinformatics and further confirmed by dual-luciferase reporter assay and qRT-PCR. Cancer cells were transfected with siMTDH, MTDH, miR-9-3p inhibitor, or mimics and treated by Gem, then CCK-8, colony formation assay, tube formation assay, flow cytometry, wound healing assay, and Transwell were performed to explore the effects of MTDH, miR-9-3p, and Gem on cancer cell growth, apoptosis, migration, and invasion. Expressions of VEGF, p53, cleaved caspase-3, MMP-2, MMP-9, E-Cadherin, N-Cadherin, and Vimentin were determined by Western blot. MTDH was high-expressed in cancer tissues and cells, and the cells with high-expressed MTDH were less sensitive to Gem, while silencing MTDH expression significantly promoted the effect of Gem on inducing apoptosis, inhibiting cell migration, invasion, and growth, and on regulating protein expressions of cancer cells. Moreover, miR-9-3p had a targeted binding relationship with MTDH, and overexpressed miR-9-3p greatly promoted the toxic effects of Gem on cancer cells and expressions of apoptosis-related proteins, whereas overexpressed MTDH partially reversed such effects of overexpressed miR-9-3p. The study proved that miR-9-3p regulates biological functions, drug resistance, and the growth of Gem-treated breast cancer cells through targeting MTDH.

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