Potential Role of β1 Integrin and Collagen Biosynthesis in Estrogen-Dependent Reduction of Apoptosis in Tamoxifen-Treated Breast Cancer Cells

2001 ◽  
Vol 51 (4) ◽  
pp. 248-253 ◽  
Author(s):  
Milena Dabrowska ◽  
Jerzy Palka ◽  
Slawomir Wolczynski ◽  
Miroslawa Pietruczuk ◽  
Joanna Osada
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Potential Role ◽  
Β1 Integrin ◽  
Collagen Biosynthesis ◽  
Treated Breast ◽  
Treated Breast Cancer

Beneficial effects of the redox-active complex Cu[15]pyN5 in doxorubicin-treated breast cancer cells

2012 ◽  
Vol 53 ◽  
pp. S119-S120
Author(s):  
A.S. Fernandes⁎ ◽  
M. Cipriano ◽  
J. Costa ◽  
M.F. Cabral ◽  
J. Miranda ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Active Complex ◽  
Beneficial Effects ◽  
Redox Active ◽  
Treated Breast ◽  
Treated Breast Cancer

scholarly journals MiR-9-3p regulates the biological functions and drug resistance of gemcitabine-treated breast cancer cells and affects tumor growth through targeting MTDH

2021 ◽  
Vol 12 (10) ◽  
Author(s):  
Yike Wang ◽  
Lifeng Dong ◽  
Fang Wan ◽  
Fangfang Chen ◽  
Dianlei Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Breast Cancer Cells ◽  
Biological Functions ◽  
Qrt Pcr ◽  
Treated Breast ◽  
Cancer Tissues ◽  
Treated Breast Cancer

AbstractThis study explored the role of MTDH in regulating the sensitivity of breast cancer cell lines to gemcitabine (Gem) and the potential miRNAs targeting MTDH. The expression of MTDH in cancer tissues and cells was detected by immunohistochemical staining or qRT-PCR. The target genes for MTDH were predicted by bioinformatics and further confirmed by dual-luciferase reporter assay and qRT-PCR. Cancer cells were transfected with siMTDH, MTDH, miR-9-3p inhibitor, or mimics and treated by Gem, then CCK-8, colony formation assay, tube formation assay, flow cytometry, wound healing assay, and Transwell were performed to explore the effects of MTDH, miR-9-3p, and Gem on cancer cell growth, apoptosis, migration, and invasion. Expressions of VEGF, p53, cleaved caspase-3, MMP-2, MMP-9, E-Cadherin, N-Cadherin, and Vimentin were determined by Western blot. MTDH was high-expressed in cancer tissues and cells, and the cells with high-expressed MTDH were less sensitive to Gem, while silencing MTDH expression significantly promoted the effect of Gem on inducing apoptosis, inhibiting cell migration, invasion, and growth, and on regulating protein expressions of cancer cells. Moreover, miR-9-3p had a targeted binding relationship with MTDH, and overexpressed miR-9-3p greatly promoted the toxic effects of Gem on cancer cells and expressions of apoptosis-related proteins, whereas overexpressed MTDH partially reversed such effects of overexpressed miR-9-3p. The study proved that miR-9-3p regulates biological functions, drug resistance, and the growth of Gem-treated breast cancer cells through targeting MTDH.

scholarly journals The paracrine effects of fibroblasts on Doxorubicin-treated breast cancer cells

2019 ◽  
Vol 381 (2) ◽  
pp. 280-287
Author(s):  
Carla Fourie ◽  
Tanja Davis ◽  
Jurgen Kriel ◽  
Anna-Mart Engelbrecht
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Paracrine Effects ◽  
Treated Breast ◽  
Treated Breast Cancer

Effect of vitamin E on tamoxifen-treated breast cancer cells

Surgery ◽  
2006 ◽  
Vol 140 (4) ◽  
pp. 607-615 ◽  
Author(s):  
Elizabeth A. Peralta ◽  
Melita L. Viegas ◽  
Somaja Louis ◽  
Deborah L. Engle ◽  
Gary L. Dunnington
Keyword(s):  
Breast Cancer ◽  
Vitamin E ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Treated Breast ◽  
Treated Breast Cancer
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