scholarly journals Acoustic Field Characterization of Medical Array Transducers Based on Unfocused Transmits and Single-Plane Hydrophone Measurements

Sensors ◽  
2019 ◽  
Vol 19 (4) ◽  
pp. 863 ◽  
Author(s):  
Torben Marhenke ◽  
Sergio Sanabria ◽  
Bhaskara Chintada ◽  
Roman Furrer ◽  
Jürg Neuenschwander ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Sound Field ◽  
Field Measurements ◽  
Spatial Location ◽  
Clinical Safety ◽  
Single Plane ◽  
Sommerfeld Integral ◽  
Wavelength Resolution ◽  
Safety Parameters

Medical ultrasonic arrays are typically characterized in controlled water baths using measurements by a hydrophone, which can be translated with a positioning stage. Characterization of 3D acoustic fields conventionally requires measurements at each spatial location, which is tedious and time-consuming, and may be prohibitive given limitations of experimental setup (e.g., the bath and stage) and measurement equipment (i.e., the hydrophone). Moreover, with the development of new ultrasound sequences and modalities, multiple measurements are often required to characterize each imaging mode to ensure performance and clinical safety. Acoustic holography allows efficient characterization of source transducer fields based on single plane measurements. In this work, we explore the applicability of a re-radiation method based on the Rayleigh–Sommerfeld integral to medical imaging array characterization. We show that source fields can be reconstructed at single crystal level at wavelength resolution, based on far-field measurements. This is herein presented for three practical application scenarios: for identifying faulty transducer elements; for characterizing acoustic safety parameters in focused ultrasound sequences from 2D planar measurements; and for estimating arbitrary focused fields based on calibration from an unfocused sound field and software beamforming. The results experimentally show that the acquired pressure fields closely match those estimated using our technique.

scholarly journals Focused ultrasound in neuro-oncology: the role of the Focused Ultrasound Foundation in driving adoption and innovation

2021 ◽  
Author(s):  
Emily C. Whipple ◽  
Camille A. Favero ◽  
Neal F. Kassell
Keyword(s):  
Drug Delivery ◽  
Brain Tumors ◽  
Focused Ultrasound ◽  
Clinical Evidence ◽  
Neurological Injury ◽  
High Concentration ◽  
Potential Applications ◽  
Tumor Agent

Abstract Introduction Intra-arterial (lA) delivery of therapeutic agents across the blood-brain barrier (BBB) is an evolving strategy which enables the distribution of high concentration therapeutics through a targeted vascular territory, while potentially limiting systemic toxicity. Studies have demonstrated lA methods to be safe and efficacious for a variety of therapeutics. However, further characterization of the clinical efficacy of lA therapy for the treatment of brain tumors and refinement of its potential applications are necessary. Methods We have reviewed the preclinical and clinical evidence supporting superselective intraarterial cerebral infusion (SSJACI) with BBB disruption for the treatment of brain tumors. In addition, we review ongoing clinical trials expanding the applicability and investigating the efficacy of lA therapy for the treatment of brain tumors. Results Trends in recent studies have embraced the use of SSIACI and less neurotoxic chemotherapies. The majority of trials continue to use mannitol as the preferred method of hyperosmolar BBB disruption. Recent preclinical and preliminary human investigations into the lA delivery of Bevacizumab have demonstrated its safety and efficacy as an anti-tumor agent both alone and in combination with chemotherapy. Conclusion lA drug delivery may significantly affect the way treatment are delivered to patients with brain tumors, and in particular GBM. With refinement and standardization of the techniques of lA drug delivery, improved drug selection and formulations, and the development of methods to minimize treatment-related neurological injury, lA therapy may offer significant benefits for the treatment of brain tumors.

scholarly journals Spiral Sound Wave Transducer Based on the Longitudinal Vibration

Sensors ◽  
2018 ◽  
Vol 18 (11) ◽  
pp. 3674 ◽  
Author(s):  
Wei Lu ◽  
Yu Lan ◽  
Rongzhen Guo ◽  
Qicheng Zhang ◽  
Shichang Li ◽  
...  
Keyword(s):  
Sound Wave ◽  
Longitudinal Vibration ◽  
Three Dimensional ◽  
Low Frequency ◽  
Sound Field ◽  
Field Measurements ◽  
Sound Waves ◽  
Underwater Sound ◽  
Three Dimensional Finite Element ◽  
Wave Transducer

A spiral sound wave transducer comprised of longitudinal vibrating elements has been proposed. This transducer was made from eight uniform radial distributed longitudinal vibrating elements, which could effectively generate low frequency underwater acoustic spiral waves. We discuss the production theory of spiral sound waves, which could be synthesized by two orthogonal acoustic dipoles with a phase difference of 90 degrees. The excitation voltage distribution of the transducer for emitting a spiral sound wave and the measurement method for the transducer is given. Three-dimensional finite element modeling (FEM)of the transducer was established for simulating the vibration modes and the acoustic characteristics of the transducers. Further, we fabricated a spiral sound wave transducer based on our design and simulations. It was found that the resonance frequency of the transducer was 10.8 kHz and that the transmitting voltage resonance was 140.5 dB. The underwater sound field measurements demonstrate that our designed transducer based on the longitudinal elements could successfully generate spiral sound waves.

scholarly journals Temporal evolution of flow-like landslide hazard for a road infrastructure in the municipality of Nocera Inferiore (southern Italy) under the effect of climate change

2018 ◽  
Vol 18 (11) ◽  
pp. 3019-3035 ◽  
Author(s):  
Marco Uzielli ◽  
Guido Rianna ◽  
Fabio Ciervo ◽  
Paola Mercogliano ◽  
Unni K. Eidsvig
Keyword(s):  
Climate Change ◽  
Southern Italy ◽  
Spatial Location ◽  
Temporal Variations ◽  
Landslide Hazard ◽  
Climate Projections ◽  
Atmospheric Concentration ◽  
Campania Region ◽  
Event Occurrence

Abstract. In recent years, flow-like landslides have extensively affected pyroclastic covers in the Campania region in southern Italy, causing human suffering and conspicuous economic damages. Due to the high criticality of the area, a proper assessment of future variations in event occurrences due to expected climate changes is crucial. The study assesses the temporal variation in flow-like landslide hazard for a section of the A3 “Salerno–Napoli” motorway, which runs across the toe of the Monte Albino relief in the Nocera Inferiore municipality. Hazard is estimated spatially depending on (1) the likelihood of rainfall-induced event occurrence within the study area and (2) the probability that the any specific location in the study area will be affected during the runout. The probability of occurrence of an event is calculated through the application of Bayesian theory. Temporal variations due to climate change are estimated up to the year 2100 through an ensemble of high-resolution climate projections, accounting for current uncertainties in the characterization of variations in rainfall patterns. Reach probability, or defining the probability that a given spatial location is affected by flow-like landslides, is calculated spatially based on a distributed empirical model. The outputs of the study predict substantial increases in occurrence probability over time for two different scenarios of future socioeconomic growth and atmospheric concentration of greenhouse gases.

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