scholarly journals Advances in Molecularly Imprinting Technology for Bioanalytical Applications

Sensors ◽  
2019 ◽  
Vol 19 (1) ◽  
pp. 177 ◽  
Author(s):  
Runfa Li ◽  
Yonghai Feng ◽  
Guoqing Pan ◽  
Lei Liu
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Rapid Development ◽  
Electrochemical Sensing ◽  
Harsh Environments ◽  
Working Mechanism ◽  
Major Objective ◽  
Biomolecule Detection ◽  
Molecular Imprinting Technology ◽  
Molecularly Imprinting Technology ◽  
Bioanalytical Applications

In recent years, along with the rapid development of relevant biological fields, there has been a tremendous motivation to combine molecular imprinting technology (MIT) with biosensing. In this situation, bioprobes and biosensors based on molecularly imprinted polymers (MIPs) have emerged as a reliable candidate for a comprehensive range of applications, from biomolecule detection to drug tracking. Unlike their precursors such as classic immunosensors based on antibody binding and natural receptor elements, MIPs create complementary cavities with stronger binding affinity, while their intrinsic artificial polymers facilitate their use in harsh environments. The major objective of this work is to review recent MIP bioprobes and biosensors, especially those used for biomolecules and drugs. In this review, MIP bioprobes and biosensors are categorized by sensing method, including optical sensing, electrochemical sensing, gravimetric sensing and magnetic sensing, respectively. The working mechanism(s) of each sensing method are thoroughly discussed. Moreover, this work aims to present the cutting-edge structures and modifiers offering higher properties and performances, and clearly point out recent efforts dedicated to introduce multi-sensing and multi-functional MIP bioprobes and biosensors applicable to interdisciplinary fields.

scholarly journals Molecularly Imprinted Polymers Combined with Electrochemical Sensors for Food Contaminants Analysis

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4607
Author(s):  
Dounia Elfadil ◽  
Abderrahman Lamaoui ◽  
Flavio Della Pelle ◽  
Aziz Amine ◽  
Dario Compagnone
Keyword(s):  
Food Safety ◽  
Molecularly Imprinted Polymers ◽  
Electrochemical Sensors ◽  
Low Cost ◽  
Electrochemical Analysis ◽  
Ease Of Use ◽  
Electrochemical Sensing ◽  
Food Contaminants ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

Detection of relevant contaminants using screening approaches is a key issue to ensure food safety and respect for the regulatory limits established. Electrochemical sensors present several advantages such as rapidity; ease of use; possibility of on-site analysis and low cost. The lack of selectivity for electrochemical sensors working in complex samples as food may be overcome by coupling them with molecularly imprinted polymers (MIPs). MIPs are synthetic materials that mimic biological receptors and are produced by the polymerization of functional monomers in presence of a target analyte. This paper critically reviews and discusses the recent progress in MIP-based electrochemical sensors for food safety. A brief introduction on MIPs and electrochemical sensors is given; followed by a discussion of the recent achievements for various MIPs-based electrochemical sensors for food contaminants analysis. Both electropolymerization and chemical synthesis of MIP-based electrochemical sensing are discussed as well as the relevant applications of MIPs used in sample preparation and then coupled to electrochemical analysis. Future perspectives and challenges have been eventually given.

scholarly journals Graphene Quantum Dots-Based Nanocomposites Applied in Electrochemical Sensors: A Recent Survey

Electrochem ◽  
2021 ◽  
Vol 2 (3) ◽  
pp. 490-519
Author(s):  
Murilo H. M. Facure ◽  
Rodrigo Schneider ◽  
Jessica B. S. Lima ◽  
Luiza A. Mercante ◽  
Daniel S. Correa
Keyword(s):  
Quantum Dots ◽  
Molecularly Imprinted Polymers ◽  
Electrochemical Sensors ◽  
Graphene Quantum Dots ◽  
Electrochemical Sensing ◽  
Synthesis Methods ◽  
Current Trends ◽  
Sensing Platforms ◽  
Metal Organic ◽  
2D Nanomaterials

Graphene quantum dots (GQDs) have been widely investigated in recent years due to their outstanding physicochemical properties. Their remarkable characteristics allied to their capability of being easily synthesized and combined with other materials have allowed their use as electrochemical sensing platforms. In this work, we survey recent applications of GQDs-based nanocomposites in electrochemical sensors and biosensors. Firstly, the main characteristics and synthesis methods of GQDs are addressed. Next, the strategies generally used to obtain the GQDs nanocomposites are discussed. Emphasis is given on the applications of GQDs combined with distinct 0D, 1D, 2D nanomaterials, metal-organic frameworks (MOFs), molecularly imprinted polymers (MIPs), ionic liquids, as well as other types of materials, in varied electrochemical sensors and biosensors for detecting analytes of environmental, medical, and agricultural interest. We also discuss the current trends and challenges towards real applications of GQDs in electrochemical sensors.

Facile construction of reduced graphene oxide–carbon dot complex embedded molecularly imprinted polymers for dual-amplification and selective electrochemical sensing of rutoside

2017 ◽  
Vol 41 (18) ◽  
pp. 9977-9983 ◽  
Author(s):  
Huijun Guo ◽  
Rijun Gui ◽  
Hui Jin ◽  
Zonghua Wang
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Molecularly Imprinted Polymers ◽  
Electrochemical Sensing ◽  
Molecularly Imprinted ◽  
Carbon Dot ◽  
Imprinted Polymers ◽  
Reduced Graphene ◽  
Dual Amplification

This article reported reduced graphene oxide–carbon dot embedded molecularly imprinted polymers for sensitive and selective electrochemical sensing of rutoside.

Recognition and Electrochemical Sensing of 8-Hydroxydeoxyguanosine with Molecularly Imprinted Poly (ethylene-co-vinyl alcohol) Thin Films

2011 ◽  
Vol 495 ◽  
pp. 331-334 ◽  
Author(s):  
Mei Hwa Lee ◽  
Tain Chin Tsai ◽  
Chun Yueh Huang ◽  
Bin Da Liu ◽  
Hung Yin Lin
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Biological Fluid ◽  
Biological Fluids ◽  
Electrochemical Sensing ◽  
Protein Nitrogen ◽  
Molecularly Imprinted ◽  
Complex Chemical ◽  
Chemical Background ◽  
Recognition Elements ◽  
Poly Ethylene

Biosensors using the mechanisms of electrochemical, optical, mass sensitive thermometric and magnetometric have been intensively investigated [1], and molecularly imprinted polymers (MIPs) has been used as recognition elements in sensors reviewed in numerous articles [1-3]. A severe challenge for MIP sensors is detection in chemically diverse environments, such as biological fluids [4-7]. There are many biomarkers discovered in biological fluid, like cerebrospinal fluid (CSF), saliva, serum and urine. Important biomarkers such as creatinine [4], urea, and albumin [8], urine contains non-protein nitrogen metabolites, carbohydrates [9], proteins and amino acids [10]; detection of analytes must be made amid this complex chemical background.

scholarly journals Electrochemical Impedance Spectroscopy on 2D Nanomaterial MXene Modified Interfaces: Application as a Characterization and Transducing Tool

Chemosensors ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 127
Author(s):  
Juvissan Aguedo ◽  
Lenka Lorencova ◽  
Marek Barath ◽  
Pavol Farkas ◽  
Jan Tkac
Keyword(s):  
Electrochemical Impedance Spectroscopy ◽  
Impedance Spectroscopy ◽  
Molecularly Imprinted Polymers ◽  
Electrochemical Impedance ◽  
Electrochemical Sensing ◽  
Label Free ◽  
Preparation Route ◽  
Basic Characteristics ◽  
Electrochemical Interfaces

This review presents the basic characteristics of MXene, a novel 2D nanomaterial with many outstanding properties applicable to electrochemical sensing and biosensing. The second part deals with electrochemical impedance spectroscopy (EIS) and its beneficial features applicable to ultrasensitive electrochemical sensing and label-free biosensing. The main part of the review presents recent advances in the integration of MXene to design electrochemical interfaces. EIS was used to evaluate the effect of anodic potential on MXene and the effect of the MXene preparation route and for characterization of MXene grafted with polymers. It also included the application of EIS as the main transducing tool for antibody- and aptamer-based biosensors or biosensors integrating molecularly imprinted polymers.

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