scholarly journals A Handheld Real-Time Photoacoustic Imaging System for Animal Neurological Disease Models: From Simulation to Realization

Sensors ◽  
2018 ◽  
Vol 18 (11) ◽  
pp. 4081 ◽  
Author(s):  
Yu-Hang Liu ◽  
Yu Xu ◽  
Lun-De Liao ◽  
Kim Chan ◽  
Nitish Thakor
Keyword(s):  
Real Time ◽  
Neurological Disease ◽  
Cerebral Blood Volume ◽  
Soft Tissues ◽  
Imaging System ◽  
Photoacoustic Imaging ◽  
Maximum Intensity Projection ◽  
Disease Models ◽  
Depth Information ◽  
Functional Impairments

This article provides a guide to design and build a handheld, real-time photoacoustic (PA) imaging system from simulation to realization for animal neurological disease models. A pulsed laser and array-based ultrasound (US) platform were utilized to develop the system for evaluating vascular functions in rats with focal ischemia or subcutaneous tumors. To optimize the laser light delivery, finite element (FE)-based simulation models were developed to provide information regarding light propagation and PA wave generation in soft tissues. Besides, simulations were also conducted to evaluate the ideal imaging resolution of the US system. As a result, a PA C-scan image of a designed phantom in 1% Lipofundin was reconstructed with depth information. Performance of the handheld PA system was tested in an animal ischemia model, which revealed that cerebral blood volume (CBV) changes at the cortical surface could be monitored immediately after ischemia induction. Another experiment on subcutaneous tumors showed the anomalous distribution of the total hemoglobin concentration (HbT) and oxygen saturation (SO2), while 3D and maximum intensity projection (MIP) PA images of the subcutaneous tumors are also presented in this article. Overall, this system shows promise for monitoring disease progression in vascular functional impairments.

scholarly journals Development of an X-ray real-time stereo imaging technique using synchrotron radiation

2011 ◽  
Vol 18 (4) ◽  
pp. 569-574 ◽  
Author(s):  
Masato Hoshino ◽  
Kentaro Uesugi ◽  
James Pearson ◽  
Takashi Sonobe ◽  
Mikiyasu Shirai ◽  
...  
Keyword(s):  
Synchrotron Radiation ◽  
Real Time ◽  
Imaging System ◽  
Silicon Crystal ◽  
Three Dimensional ◽  
Stereo Image ◽  
Large Field ◽  
Depth Information ◽  
Stereo Imaging ◽  
X Ray

An X-ray stereo imaging system with synchrotron radiation was developed at BL20B2, SPring-8. A portion of a wide X-ray beam was Bragg-reflected by a silicon crystal to produce an X-ray beam which intersects with the direct X-ray beam. Samples were placed at the intersection point of the two beam paths. X-ray stereo images were recorded simultaneously by a detector with a large field of view placed close to the sample. A three-dimensional wire-frame model of a sample was created from the depth information that was obtained from the lateral positions in the stereo image. X-ray stereo angiography of a mouse femoral region was performed as a demonstration of real-time stereo imaging. Three-dimensional arrangements of the femur and blood vessels were obtained.

A pilot study of photoacoustic imaging system for improved real-time visualization of neurovascular bundle during radical prostatectomy

The Prostate ◽  
2015 ◽  
Vol 76 (3) ◽  
pp. 307-315 ◽  
Author(s):  
Akio Horiguchi ◽  
Kazuhiro Tsujita ◽  
Kaku Irisawa ◽  
Tadashi Kasamatsu ◽  
Kazuhiro Hirota ◽  
...  
Keyword(s):  
Pilot Study ◽  
Radical Prostatectomy ◽  
Real Time ◽  
Imaging System ◽  
Photoacoustic Imaging ◽  
Neurovascular Bundle ◽  
Real Time Visualization

scholarly journals Towards clinical photoacoustic and ultrasound imaging: Probe improvement and real-time graphical user interface

2020 ◽  
Vol 245 (4) ◽  
pp. 321-329 ◽  
Author(s):  
Jeesu Kim ◽  
Eun-Yeong Park ◽  
Byullee Park ◽  
Wonseok Choi ◽  
Ki J Lee ◽  
...  
Keyword(s):  
User Interface ◽  
Real Time ◽  
Ultrasound Imaging ◽  
Graphical User Interface ◽  
Imaging System ◽  
Photoacoustic Imaging ◽  
Clinical Applications ◽  
Imaging Systems ◽  
Imaging Probe ◽  
Conventional Ultrasound

Photoacoustic imaging is a non-invasive and non-ionizing biomedical technique that has been investigated widely for various clinical applications. By taking the advantages of conventional ultrasound imaging, hand-held operation with a linear array transducer should be favorable for successful clinical translation of photoacoustic imaging. In this paper, we present new key updates contributed to the previously developed real-time clinical photoacoustic and ultrasound imaging system for improving the clinical usability of the system. We developed a seamless image optimization platform, designed a real-time parameter control software with a user-friendly graphical user interface, performed Monte Carlo simulation of the optical fluence in the imaging plane, and optimized the geometry of the imaging probe. The updated system allows optimizing of all imaging parameters while continuously acquiring the photoacoustic and ultrasound images in real-time. The updated system has great potential to be used in a variety of clinical applications such as assessing the malignancy of thyroid cancer, breast cancer, and melanoma. Impact statement Photoacoustic imaging is a promising biomedical imaging modality that can visualize both structural and functional information of biological tissue. Because of its easiness to be integrated with conventional ultrasound imaging systems, numerous studies have been conducted to develop and apply clinical photoacoustic imaging systems. However, most of the systems were not suitable for general-purpose clinical applications due to one of the following reasons: target specific design, immobility, inaccessible operation sequence, and lack of hand-held operation. This study demonstrates a real-time clinical photoacoustic and ultrasound imaging system, which can overcome the limitations of the previous systems for successful clinical translation.

Development of Real-Time 3-D Photoacoustic Imaging System Employing Spherically Curved Array Transducer

2017 ◽  
Vol 64 (8) ◽  
pp. 1223-1233 ◽  
Author(s):  
Ryo Nagaoka ◽  
Takuya Tabata ◽  
Ryo Takagi ◽  
Shin Yoshizawa ◽  
Shin-Ichiro Umemura ◽  
...  
Keyword(s):  
Real Time ◽  
Imaging System ◽  
Photoacoustic Imaging ◽  
Array Transducer ◽  
Curved Array Transducer

Real-Time Photoacoustic Imaging System Based on Phase Contrast Demodulation

2016 ◽  
Vol 53 (7) ◽  
pp. 071701
Author(s):  
张宇 Zhang Yu ◽  
薛月菊 Xue Yueju ◽  
贾金亮 Jia Jinliang ◽  
金晓勇 Jin Xiaoyong ◽  
刘洪山 Liu Hongshan ◽  
...  
Keyword(s):  
Real Time ◽  
Phase Contrast ◽  
Imaging System ◽  
Photoacoustic Imaging

scholarly journals Real-time photoacoustic imaging system for burn diagnosis

2014 ◽  
Vol 19 (8) ◽  
pp. 086013 ◽  
Author(s):  
Taiichiro Ida ◽  
Yasushi Kawaguchi ◽  
Satoko Kawauchi ◽  
Keiichi Iwaya ◽  
Hitoshi Tsuda ◽  
...  
Keyword(s):  
Real Time ◽  
Imaging System ◽  
Photoacoustic Imaging

scholarly journals Intraoperative biophotonic imaging systems for image-guided interventions

Nanophotonics ◽  
2018 ◽  
Vol 8 (1) ◽  
pp. 99-116 ◽  
Author(s):  
Salar Sajedi ◽  
Hamid Sabet ◽  
Hak Soo Choi
Keyword(s):  
Real Time ◽  
Near Infrared ◽  
Imaging System ◽  
Nuclear Imaging ◽  
Imaging Systems ◽  
Quantitative Detection ◽  
Depth Information ◽  
Image Guided ◽  
Nir Fluorescence ◽  
Biophotonic Imaging

AbstractBiophotonic imaging has revolutionized the operation room by providing surgeons intraoperative image-guidance to diagnose tumors more efficiently and to resect tumors with real-time image navigation. Among many medical imaging modalities, near-infrared (NIR) light is ideal for image-guided surgery because it penetrates relatively deeply into living tissue, while nuclear imaging provides quantitative and unlimited depth information. It is therefore ideal to develop an integrated imaging system by combining NIR fluorescence and gamma-positron imaging to provide surgeons with highly sensitive and quantitative detection of diseases, such as cancer, in real-time without changing the look of the surgical field. The focus of this review is to provide recent progress in intraoperative biophotonic imaging systems, NIR fluorescence imaging and intraoperative nuclear imaging devices, and their future perspectives for image-guided interventions.

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