scholarly journals Correlating the Integral Sensing Properties of Zeolites with Molecular Processes by Combining Broadband Impedance and DRIFT Spectroscopy—A New Approach for Bridging the Scales

Sensors ◽  
2015 ◽  
Vol 15 (11) ◽  
pp. 28915-28941 ◽  
Author(s):  
Peirong Chen ◽  
Simon Schönebaum ◽  
Thomas Simons ◽  
Dieter Rauch ◽  
Markus Dietrich ◽  
...  
Keyword(s):  
Molecular Processes ◽  
Drift Spectroscopy ◽  
New Approach ◽  
Sensing Properties

Combining a sensor and a pH-gated nanopore based on an avidin–biotin system

2015 ◽  
Vol 51 (27) ◽  
pp. 5994-5997 ◽  
Author(s):  
Mathilde Lepoitevin ◽  
Gael Nguyen ◽  
Mikhael Bechelany ◽  
Emmanuel Balanzat ◽  
Jean-Marc Janot ◽  
...  
Keyword(s):  
New Approach ◽  
Sensing Properties ◽  
System P

Here we propose a new approach to tailor nanopores, which combines both pH gating and sensing properties.

scholarly journals Patient stratification reveals the molecular basis of disease comorbidities

2021 ◽  
Author(s):  
Beatriz Urda-Garcia ◽  
Jon Sanchez-Valle ◽  
Rosalba Lepore ◽  
Alfonso Valencia
Keyword(s):  
Large Scale ◽  
Molecular Mechanisms ◽  
Expression Profiles ◽  
Patient Stratification ◽  
Rna Seq ◽  
Biological Models ◽  
Molecular Processes ◽  
Epidemiological Evidence ◽  
New Approach ◽  
Secondary Condition

Epidemiological evidence shows that some diseases tend to co-occur; more exactly, certain groups of patients with a given disease are at a higher risk of developing a specific secondary condition. Despite the considerable interest, only a small number of connections between comorbidities and molecular processes have been identified. Here we develop a new approach to generate a disease network that uses the accumulating RNA-seq data on human diseases to significantly match a large number of known comorbidities, providing plausible biological models for such co-occurrences. Furthermore, 64% of the known disease pairs can be explained by analysing groups of patients with similar expression profiles, highlighting the importance of patient stratification in the study of comorbidities. These results solidly support the existence of molecular mechanisms behind many of the known comorbidities. All the information can be explored on a large scale and in detail at http://disease-perception.bsc.es/rgenexcom/.

scholarly journals Emerging Nanoparticles in the Diagnosis of Atherosclerosis

2021 ◽  
Vol 70 (2) ◽  
Author(s):  
Tanushka Kataria ◽  
Sadique Hussain ◽  
Gurleen Kaur ◽  
Anuska Deb
Keyword(s):  
Review Paper ◽  
Functional Organization ◽  
Molecular Processes ◽  
Cardiovascular Research ◽  
New Approach ◽  
The Past ◽  
Atherosclerotic Lesions ◽  
Common Causes ◽  
Atherosclerotic Process ◽  
Molecular Components

Throughout the last few decades, cardiovascular research has substantially advanced our awareness of the atherosclerotic process, the molecular processes underlying the disease remain essentially unexplained. Atherosclerosis results from the imbalanced lipid metabolism and lipoproteins accumulation that results in the thickening of the artery walls, linked to most cardiovascular events, and also one of the foremost common causes of morbidity and mortality around the world. Despite the extensive investigation into the process of development and advancement of atherosclerotic lesions over the years, there is little information is available. The use and handling of nanotechnology on a molecular scale is a new approach to quantify the functional organization in nanometers. In medicine, it is capable to improve diagnostics, delivery of pharmaceuticals, treatment, and many areas of research, development, and clinical application. Medical nanotechnology or nanomedicine has demonstrated a growing trend in the reduction of costs and improve the efficiency of current medicines, diagnostic reagents, implants, etc. Nanomedicine overcomes certain problems of conventional drugs like drug toxicity and the required dose of the drug. Promising research has resulted in pre-clinical validation of nanoscale devices targeting cell and molecular components of atherosclerotic plaque in the past decade. This review paper will cover basic insights into the use of nanomedicine in atherosclerosis

A new approach to polycyclic azaarenes: visible-light photolysis of vinyl azides in the synthesis of diazabenzopyrene and diazaperylene

2016 ◽  
Vol 4 (30) ◽  
pp. 7269-7276 ◽  
Author(s):  
J. A. Schneider ◽  
D. F. Perepichka
Keyword(s):  
Visible Light ◽  
Fluorescence Sensing ◽  
Dual Mode ◽  
New Approach ◽  
Sensing Properties ◽  
Vinyl Azides ◽  
Indole Synthesis

The Hemetsberger indole synthesis was repurposed for the preparation of luminescent electron-deficient azaarenes which display dual-mode pH fluorescence sensing properties.

The O–C diagrams of minor planets − a new approach to modelling the rotation

1999 ◽  
Vol 173 ◽  
pp. 185-188
Author(s):  
Gy. Szabó ◽  
K. Sárneczky ◽  
L.L. Kiss
Keyword(s):  
Error Analysis ◽  
Time Dependence ◽  
Theoretical Work ◽  
Minor Planet ◽  
Minor Planets ◽  
New Approach ◽  
Preliminary Results ◽  
Ccd Observations

AbstractA widely used tool in studying quasi-monoperiodic processes is the O–C diagram. This paper deals with the application of this diagram in minor planet studies. The main difference between our approach and the classical O–C diagram is that we transform the epoch (=time) dependence into the geocentric longitude domain. We outline a rotation modelling using this modified O–C and illustrate the abilities with detailed error analysis. The primary assumption, that the monotonity and the shape of this diagram is (almost) independent of the geometry of the asteroids is discussed and tested. The monotonity enables an unambiguous distinction between the prograde and retrograde rotation, thus the four-fold (or in some cases the two-fold) ambiguities can be avoided. This turned out to be the main advantage of the O–C examination. As an extension to the theoretical work, we present some preliminary results on 1727 Mette based on new CCD observations.

A New Approach to the Demonstration of Oxidase-Localization Using Tannic Acid Or Catechin

1973 ◽  
Vol 31 ◽  
pp. 698-699
Author(s):  
V. Mizuhira ◽  
Y. Futaesaku
Keyword(s):  
Cross Section ◽  
Tannic Acid ◽  
Elastic Fiber ◽  
The Other ◽  
New Approach ◽  
Tissue Block ◽  
Active Reaction ◽  
The Cross

Previously we reported that tannic acid is a very effective fixative for proteins including polypeptides. Especially, in the cross section of microtubules, thirteen submits in A-tubule and eleven in B-tubule could be observed very clearly. An elastic fiber could be demonstrated very clearly, as an electron opaque, homogeneous fiber. However, tannic acid did not penetrate into the deep portion of the tissue-block. So we tried Catechin. This shows almost the same chemical natures as that of proteins, as tannic acid. Moreover, we thought that catechin should have two active-reaction sites, one is phenol,and the other is catechole. Catechole site should react with osmium, to make Os- black. Phenol-site should react with peroxidase existing perhydroxide.

Processing Immunoperoxidase Labeled Cell Monolayers and Cryostat Sesctions For Electron Microscopy

1985 ◽  
Vol 43 ◽  
pp. 714-715
Author(s):  
K. Chien ◽  
R. Van de Velde ◽  
I.P. Shintaku ◽  
A.F. Sassoon
Keyword(s):  
Cell Monolayer ◽  
Cell Types ◽  
Surface Antigens ◽  
Immunoperoxidase Method ◽  
Reaction Step ◽  
Hot Plate ◽  
Air Drying ◽  
New Approach ◽  
Cell Monolayers ◽  
Glass Slides

Immunoelectron microscopy of neoplastic lymphoma cells is valuable for precise localization of surface antigens and identification of cell types. We have developed a new approach in which the immunohistochemical staining can be evaluated prior to embedding for EM and desired area subsequently selected for ultrathin sectioning.A freshly prepared lymphoma cell suspension is spun onto polylysine hydrobromide- coated glass slides by cytocentrifugation and immediately fixed without air drying in polylysine paraformaldehyde (PLP) fixative. After rinsing in PBS, slides are stained by a 3-step immunoperoxidase method. Cell monolayer is then fixed in buffered 3% glutaraldehyde prior to DAB reaction. After the DAB reaction step, wet monolayers can be examined under LM for presence of brown reaction product and selected monolayers then processed by routine methods for EM and embedded with the Chien Re-embedding Mold. After the polymerization, the epoxy blocks are easily separated from the glass slides by heatingon a 100°C hot plate for 20 seconds.

TEM study of a biofilm on copper corrosion

1996 ◽  
Vol 54 ◽  
pp. 220-221
Author(s):  
W. A. Chiou ◽  
N. Kohyama ◽  
B. Little ◽  
P. Wagner ◽  
M. Meshii
Keyword(s):  
Marine Bacterium ◽  
Culture Medium ◽  
Copper Alloys ◽  
Pure Copper ◽  
Localized Corrosion ◽  
Natural Seawater ◽  
Copper Corrosion ◽  
New Approach ◽  
The Past ◽  
Copper Tolerant

The corrosion of copper and copper alloys in a marine environment is of great concern because of their widespread use in heat exchangers and steam condensers in which natural seawater is the coolant. It has become increasingly evident that microorganisms play an important role in the corrosion of a number of metals and alloys under a variety of environments. For the past 15 years the use of SEM has proven to be useful in studying biofilms and spatial relationships between bacteria and localized corrosion of metals. Little information, however, has been obtained using TEM capitalizing on its higher spacial resolution and the transmission observation of interfaces. The research presented herein is the first step of this new approach in studying the corrosion with biological influence in pure copper.Commercially produced copper (Cu, 99%) foils of approximately 120 μm thick exposed to a copper-tolerant marine bacterium, Oceanospirillum, and an abiotic culture medium were subsampled (1 cm × 1 cm) for this study along with unexposed control samples.

High resolution at low voltage: A new approach

1989 ◽  
Vol 47 ◽  
pp. 76-77
Author(s):  
Arthur V. Jones
Keyword(s):  
Low Voltage ◽  
Emission Sources ◽  
New Approach ◽  
Design Concepts ◽  
Probe Diameter ◽  
Low Voltage Operation ◽  
Sufficient Intensity ◽  
Electron Microscopes ◽  
Scanning Electron Microscopes ◽  
Immersion Type

With the introduction of field-emission sources and “immersion-type” objective lenses, the resolution obtainable with modern scanning electron microscopes is approaching that obtainable in STEM and TEM-but only with specific types of specimens. Bulk specimens still suffer from the restrictions imposed by internal scattering and the need to be conducting. Advances in coating techniques have largely overcome these problems but for a sizeable body of specimens, the restrictions imposed by coating are unacceptable.For such specimens, low voltage operation, with its low beam penetration and freedom from charging artifacts, is the method of choice.Unfortunately the technical dificulties in producing an electron beam sufficiently small and of sufficient intensity are considerably greater at low beam energies — so much so that a radical reevaluation of convential design concepts is needed.The probe diameter is usually given by

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